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20,252 grants found
Showing 3,021 – 3,040 of 20,252 grants
CEP: Career Enhancement Program
PROJECT SUMMARY – CAREER ENHANCEMENT PROGRAM (CEP) The mission of the Hillman Cancer Center (HCC) Ovarian Cancer (OvCa) SPORE Career Enhancement Program (CEP) is to foster the deve...
Znf740 in the regulation of CD8+T cell exhaustion
ABSTRACT: CAR-T cell therapy is an emerging option for cancer treatment, but its efficacy is limited, especially in solid tumors, because the effector CD8+T cells become dysfunctio...
Enhancer RNAs Boost MYC-Chromatin Interaction to Regulate Gene Expression and Tumorigenesis
Enhancer RNAs Boost MYC-Chromatin Interaction to Regulate Gene Expression and Tumorigenesis Summary: Our long-term goal is to determine how MYC’s RNA binding function contributes t...
Development and Evaluation of Advanced Non-Contrast Perfusion MRI for Monitoring Treatment Response in Brain Metastases
Project Abstract Brain metastases (BM) are the most commonly diagnosed type of central nervous system tumor, more frequent than primary intracranial neoplasms. Progress on various...
Multiplex In-Solution Protein Array (MISPA) for high throughput, quantitative, early profiling of pathogen-induced head and neck
Abstract Profiling antibody response to disease-associated antigens is important to cancer research. In contrast to the historical approach of testing responses to individual prote...
Blood-Based Biomarkers for Personalized Risk Assessment of Breast and Ovarian Cancer
Project Summary There remains a need to develop biomarker tests for personalized risk assessment of breast and ovarian cancers. Such tests would not replace screening programs but...
Transcription and Replication of Oncogenic Viruses in Hypoxia
Summary Oncogenic viruses are major contributors to approximately 20% of human cancers, with about 8 well-known viruses directly shown to be causative agents. Our program will focu...
Project 1: KSHV reprograms replication and metabolic activities in hypoxia
Project #1 Abstract KSHV-associated cancers occur in hypoxic microenvironments. The effects of hypoxia on viral and host DNA replication in the context of KSHV infection are poorly...
Project 2: KSHV induces tumorigenesis by harnessing differentiation in hypoxia
Summary Hypoxia is a characteristic feature of solid tumors and an adverse prognostic factor owing to its contributions to tumor progression and resistance to therapy. Kaposi'...
Project 3: Skin hypoxia, MCPyV infection, and MCC tumorigenesis
Project Abstract Merkel cell carcinoma (MCC) is one of the most aggressive skin cancers. Clonal integration of Merkel cell polyomavirus (MCPyV) genome into the host DNA has been ob...
Project 4: Regulation of EBV Latency and Oncogenesis by Hypoxia
Abstract: Epstein-Barr Virus (EBV) a human gammaherpesvirus that is associated with diverse lymphoid and epithelial malignancies. Like all cancers, EBV-associated cancers must comp...
Administrative Core
Abstract Core A: Program Administration The mission of the Administrative core is to maintain a cohesive program through facilitating interactions between the three projects and th...
Virus, Vector and Cell Culture Core
Abstract Core B: Virus Vector and Cell Culture Core The Virus Vector and Cell Culture Core (VVCCC) will be responsible for 1) recombinant virus design consultation, 2) vector and v...
Next Generation Sequencing Core
Summary Core C: Next Generation Sequencing core (NGSC) The next generation sequencing core (NGSC) will be responsible for all next generation sequencing activities by the four proj...
Development of Mouse and Humanized Models to Study Sex Disparities in Tumor Progression and Treatment of NSCLC
Project Summary According to the American Cancer Society, lung cancer is the second most commonly diagnosed cancer in men and women. Outside of the sex-specific cancers, lung cance...
Anticancer Effects of a Repurposed Drug in Colon Cancer
PROJECT SUMMARY/ABSTRACT About 25–30% of confirmed colon cancers (CC) without detectable local or distal invasion will eventually develop metastases, and there is currently no cure...
Long-Term Trajectories of Accelerated Biological Aging and Functional Decline Associated with Breast Cancer and its Treatment
PROJECT SUMMARY/ABSTRACT More than 3.8 million women living in the United States have a history of invasive breast cancer, a majority of whom are over age 65. With 15-year survival...
Define the oncogenic role of Plk1 during hepatocellular carcinoma development using a genetically modified mouse model
Hepatocellular carcinoma (HCC) represents one of the most common malignancies in humans and the leading cause of cancer-related death worldwide, with a steadily increasing incidenc...
Human mast cells as a platform for new cancer immunotherapy strategies
ABSTRACT The role of human tissue mast cells (MC) in the pathology of many cancers is not known. Correlative studies in humans have found high MC numbers in the tumor microenvironm...
Cancer Adoptive Cell Therapy (Can-ACT) Network Coordinating Center at Mayo Clinic
PROJECT SUMMARY/ABSTRACT – NETWORK COORDINATING CENTER The Network Coordinating Center (NCC) will facilitate and be responsible for network-wide coordination and harmonization of s...