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20,252 grants found
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The PLOD2/succinate axis in cancer cell plasticity and stemness
Abstract Tumor cells in TNBC tissue exhibit enhanced cell plasticity and stemness, which is crucial for cancer metastasis. Metabolic and epigenetic reprogramming plays crucial role...
Defining the universal genomic language of hallmarks in tumor development
PROJECT SUMMARY Genomic changes are a universal and near inevitable cause of tumor development. The field has focused mostly on tumors that rely on singular “driver” mutations to p...
Uncovering the regulatory logic of gene expression encoded by disordered regions
Cellular state, identity, and function are primarily determined by the genes expressed at a given moment. Many diseases are characterized by dysregulation of gene expression, leadi...
Development of CA-IL-12 for Triple Negative Breast Cancer
Most cancer patients die as a result of metastatic disease and our inability to effectively deliver therapeutic drugs into the anatomical niches where cancer cells thrive. Thus, th...
Development of Ubiquitin-Independent Degraders
Project Summary Degraders are chemical dimerizers that recruit a target protein (TP) to an E3 Ubiquitin (Ub) ligase. In favorable cases, this results in TP poly-Ubiquitylation and...
Microchip electrophoresis as basis for fully integrated, fully automated, low-cost radiopharmaceutical QC platform
PROJECT SUMMARY Positron emission tomography (PET) is an indispensable tool in research, drug development and clinical care, due to its very high sensitivity and quantitative natur...
A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors
Summary Cellular mRNAs are susceptible to a variety of chemical modifications that play important roles in regulating gene expression and cellular function. The most abundant inter...
Pediatric and Adult Translational Cancer Drug Discovery and Development Training Program (PACT-D3)
Abstract This training program is unique for our institution, creating the next generation of basic and clinical investigators who focus their efforts on strategic and comprehensiv...
Medical Students Summer in Oncology at Anderson Research (Med Students SOAR) program
PROJECT SUMMARY The goal of the Medical Students Summer in Oncology at Anderson Research (Med Students SOAR) program is to provide 25 talented first-year medical students per year...
Epigenetics, Metabolism and Cancer
Project Summary It is now well accepted that epigenetic and metabolic factors are major drivers of tumorigenesis and the link between the two pathways will be central in cancer the...
Creatine supplementation and resistance training to preserve muscle mass and attenuate cancer progression: A double-blind randomized controlled trial
ABSTRACT The incidence of metastatic prostate cancer has increased 3% per year since 2012, and the survival rate is only 29%. Muscle mass is important for metastatic prostate cance...
Targeting PRC1 in leukemia
Abstract Acute leukemia is an aggressive disease resulting from various genetic abnormalities and is characterized by the presence of undifferentiated blood cells. Emerging evidenc...
HCC Ovarian Cancer SPORE
PROJECT SUMMARY/ABSTRACT – OVERALL Ovarian cancer (OvCa) has the third highest mortality to incidence ratio and is the fifth leading cause of cancer death in American women. The ty...
Administrative Core
PROJECT SUMMARY/ABSTRACT – CORE A The HCC OvCa SPORE Administrative Core (Core A) is co-directed by SPORE PIs Ronald Buckanovich, MD, PhD and Robert Edwards, MD. Core A will (i) pr...
Project 1: EZH2 Inhibition to Prevent/Overcome Chemoresistance
ABSTRACT – PROJECT 1 The ability to overcome the development of chemotherapy resistance and maintain sensitivity to the most effective chemotherapy in ovarian cancer, platinum, is...
Project 2: Combination PARPi-BETi to Overcome PARPi Resistance
ABSTRACT – PROJECT 2 PARP inhibitors have emerged as an established standard of care option in epithelial ovarian cancer (OvCa). Approximately half of OvCa patients harbor inactiva...
Project 3: Hedgehog Inhibition to Enhance Response to ICI Therapy
SUMMARY/ABSTRACT – PROJECT 3 When effective, immune checkpoint inhibitor (ICI) therapy can significantly improve the outcome of patients with ovarian cancer (OvCa). However, only 1...
Core B: TCP: Translational Pathology Core
PROJECT SUMMARY – TRANSLATIONAL PATHOLOGY CORE The high case-fatality of ovarian cancer makes translational studies essential for advancing treatment and improving outcomes. The Hi...
Core C: BBC: Biostats and Bioinformatics Core
PROJECT SUMMARY – BIOSTATISTICS/BIOINFORMATICS CORE The Biostatistics/Bioinformatics Core of the Hillman Cancer Center (HCC) Ovarian Cancer (OvCa) SPORE provides services for the d...
DRP: Developmental Research Program
PROJECT SUMMARY – DEVELOPMENTAL RESEARCH PROGRAM (DRP) The Developmental Research Program (DRP) of the UPMC Hillman Cancer Center (HCC) Ovarian Cancer SPORE seeks to fund and facil...