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20,252 grants found
Showing 2,981 – 3,000 of 20,252 grants
Self-Assembling Camptothecin Nanofiber Hydrogels as Adjunct Therapy for Intraoperative Treatment of Malignant Glioma
Project summary Malignant gliomas, including the most common type glioblastoma (GBM), are histologically heterogeneous and invasive tumors known as the most devastating neoplasms w...
The role for phase separation in oncogenesis and aberrant chromatin looping formation
PROJECT SUMMARY/ABSTRACT Rearrangement of NUP98 gene (NUP98-r) is recurrent in leukemias such as acute myeloid leukemia (AML). Patients with NUP98-r show poor prognosis and therapy...
The role for phase separation in oncogenesis and aberrant chromatin looping formation
PROJECT SUMMARY/ABSTRACT Rearrangement of NUP98 gene (NUP98-r) is recurrent in leukemias such as acute myeloid leukemia (AML). Patients with NUP98-r show poor prognosis and therapy...
Self-Assembling Camptothecin Nanofiber Hydrogels as Adjunct Therapy for Intraoperative Treatment of Malignant Glioma
Project summary Malignant gliomas, including the most common type glioblastoma (GBM), are histologically heterogeneous and invasive tumors known as the most devastating neoplasms w...
NCI Clinical Trial Research Strategy, Harnessing of Equity, and Implementation
PROJECT SUMMARY/ABSTRACT I am a female board-certified radiation oncologist and Professor at the University of California (UC), San Diego, in the Department of Radiation Medicine....
Dartmouth Training Program in Quantitative Cancer Research
ABSTRACT Continued support is requested for a multidisciplinary Dartmouth Training Program in Quantitative Cancer Research (TQCR). The TQCR Program seeks to provide cross-training...
Cognitive aging in long-term breast cancer survivors
ABSTRACT Despite significant progress in understanding cognitive change associated with cancer and cancer treatments, little is known regarding longer-term cognitive outcomes over...
Examining the Role of RNF168 Activity in BRCA1 Mutant Cancers
PROJECT SUMMARY/ABSTRACT My career goal is to develop an independent research program focused on DNA damage signaling and how it can be exploited for the treatment of cancer. The w...
The role of stem-like CD8 T-cells in the abscopal response
PROJECT SUMMARY Prognosis is poor for patients diagnosed with locally advanced melanoma. Survival outcomes are improved with checkpoint blockade in the neoadjuvant, adjuvant and un...
Mechanisms and strategies to rescue suboptimal T cell priming in colon cancer
PROJECT SUMMARY/ABSTRACT I propose to functionally interrogate mechanisms of cancer immune evasion and immunotherapy resistance in powerful new mouse models of colorectal cancer (C...
Design and implementation of a social cognitive theory-based medication adherence coaching intervention
ABSTRACTDr. Benyam Muluneh’s long-term career goal is to become a leading clinician-researcher in oncology by leveraging health behavior theories and implementation science methods...
Targeting regenerative reprogramming in colorectal cancer
ABSTRACT Poorly defined fitness features enable a subset of cancer cells to survive therapy, ultimately giving rise to treatment-refractory tumors. The expanded use of sequencing t...
Metabolism of cancer chemotherapeutics by the human gut microbiome
PROJECT SUMMARY Rigorous data from our lab and others indicate that the gut microbiome may an underappreciated contributor to inter-individual variations in cancer drug efficacy an...
Transcriptional Regulation of Dormancy and Emergence in Breast Cancer
Breast cancer ranks second among cancer deaths in women in the United States. Breast cancer-related mortality primarily results from metastatic growth of disseminated cells. While...
Modeling the equity impact of age restricted in-person location policies for youth tobacco use
PROJECT SUMMARY/ABSTRACT This proposal concerns age restricted in-person location policies (ARLPs), a novel tobacco control strategy that could have a critical impact on reducing y...
Targeting Senescence to Mitigate Chemotherapy-induced Functional Decline
PROJECT SUMMARY/ABSTRACT Advances in breast cancer treatment have resulted in significant survival gains. However, cure or control of breast cancer is not necessarily accompanied b...
Role of hypoxia in CD8+ T cell exclusion and suppression in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by poor response to all existing therapies. Although immunotherapy has shown great prom...
Differentiation-focused CRISPR Screen identifies LSD1 and Menin as combination therapy targets that induce terminal differentiation in AML
Project Summary Acute myeloid leukemia (AML) is a lethal blood cancer characterized by a differentiation “block” that prevents myeloid progenitor maturation resulting in uncontroll...
Uncovering ATR signaling networks underlying chemotherapeutic synergies
PROJECT SUMMARY/ABSTRACT The DNA damage sensor kinase ATR is essential for human cell viability and plays a crucial role in cell tolerance to DNA replication stress1–3. Cancer cell...
New Hardware and Software Developments for Improving Prostate Metabolic MR Imaging
Project Summary/Abstract The proposed F31 NRSA Predoctoral Fellowship to Promote Diversity in Health-Related Research project aims to develop new MR detector hardware and acquisiti...