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20,252 grants found
Showing 281 – 300 of 20,252 grants
Development of Protein Degraders Targeting EZH2 Non-enzymatic Functions in Prostate Cancer
Summary Prostate cancer (PCa) is the most commonly diagnosed non-skin cancer in American men. A majority of localized PCa can be effectively managed by radiation and surgery, with...
Investigating epigenetic mechanisms of cancer
Project Summary Disruptions of epigenetic mechanisms that regulate gene expression are frequently found in cancer and collaborate with genetic alterations to drive cancer phenotype...
ADVANCE Cancer Health Disparities Research (CHDR) Training Program
ABSTRACT The ADVANCE Cancer Health Disparities Research (CHDR) Training Program at the University of Southern California (USC) is based on a strong foundation of biomedical researc...
The next generation of liquid biopsies: Predictive and pharmacologic biomarkers
Project Summary: The laboratory of Dr. Joshua Lang is focused on targeting treatment resistant PCa through developing new biomarkers for precision medical strategies using liquid b...
Development and Deployment of Liquid Biopsies in Bench Research and Clinical Trials in the UW Circulating Biomarker Core
Minimally invasive liquid biopsies have revolutionized our understanding of cancer biology and emerged as biomarkers for disease monitoring and drug development, but have been limi...
Exosome Secretion in Tumor Aggressiveness
PROJECT SUMMARY Exosomes are a type of small extracellular vesicle (EV) secreted from all kinds of cells, derived from endosomes. They have many physiological and pathological func...
Targeting GARP-TGFbeta for Immunotherapy of Non-Small Cell Lung Cancer
PROJECT SUMMARY Although immune checkpoint blockade (ICB) has become a standard cancer therapy, most patients – including ~70% of those with non-small cell lung cancer (NSCLC) – fa...
Analytic diagnosis methods for disease ruling
PROJECT SUMMARY/ABSTRACT Disease ruling, that is, ruling-out or ruling-in, is a main objective of cancer diagnosis to aid in medical decision making. Taking prostate cancer as our...
Developmental transcription factors in Drosha-driven cancer
PROJECT SUMMARY/ABSTRACT Pineoblastoma is one of a family of childhood cancers that can arise through mutations in microRNA processing genes DROSHA and DICER1. It is unknown whethe...
Novel Strategies to Enhance Drug Delivery and Tumor Immunogenicity in Pancreatic Cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of pancreatic cancer with limited treatment options and a low overall survival rate. Oncolytic viruses, particular...
Novel extremophile-inspired radioprotectants
Project Summary Over 60% of cancer patients undergo radiation therapy during their disease process, which frequently leads to injury to surrounding healthy tissue and results in co...
Enhancing CAR T cell fitness using novel epigenetic reprogramming factors
PROJECT SUMMARY/ABSTRACT Chimeric antigen receptor (CAR) T cell therapy has demonstrated remarkable clinical responses in patients with B cell malignancies. However, approximately...
Expanding CAR T cell applications through high-throughput forward- and reverse immune engineering
Adaptive immunity is one of the most complex and clinically relevant aspects of human biology, where immune cells have evolved over millions of years to discriminate non-self from...
A hybrid effectiveness-implementation trial to integrate precision skin cancer risk feedback in federally qualified health centers
ABSTRACT The incidence of skin cancer has increased over the past several decades. Limiting exposure to ultraviolet radiation and engaging in early detection can reduce skin cancer...
Evaluation of a Novel mHealth Intervention for People Who Are Ambivalent About Quitting Smoking: A Randomized Controlled Trial
PROJECT SUMMARY Tobacco use remains the leading preventable cause of death and illness in our society and causes 30% of cancer deaths. Despite this, 28.3 million US adults smoke. M...
Georgia Science Education Initiative NCI YES (GA-YES)
Project Summary/Abstract While the racial and ethnic diversity of the US has increased over time, the diversity of those involved in cancer and biomedical research has not reflecte...
Future Deaf Scientists Program at Wilmot Cancer Institute
PROJECT SUMMARY /ABSTRACT People with disabilities – especially deaf and hard-of-hearing individuals – continue to be underrepresented in STEM graduate programs, health science pro...
Causes and consequences of genomic instability in myelodysplasia
PROJECT SUMMARY/ABSTRACT Myelodysplastic syndromes (MDS) are a group of age-related marrow failure disorders characterized by cytopenia and anemia. It is estimated that 10,000 new...
Molecular mechanisms of developmental reprogramming in colorectal cancer
Colorectal cancer (CRC) is growing global threat, especially among younger adults. Impaired differentiation is a critical mechanism by which CRC cells unlock cell state plasticity;...
Randomized clinical trial of a telemedicine-mHealth symptom cluster intervention for advanced cancer patients: Increasing access in underserved rural communities
Abstract People with advanced cancer experience a greater frequency and severity of physical and psychological symptoms, ranking sleep difficulties, worry-anxiety, depression, and...