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20,252 grants found
Showing 2,961 – 2,980 of 20,252 grants
Epigallocatechin gallate for prevention of lethal cirrhosis complications
Summary Hepatocellular carcinoma (HCC) is the leading cause of death in patients with cirrhosis, and the fastest rising cancer mortality in the U.S. Due to the limited efficacy of...
Neurotrophic strategy to mitigate chemotherapy-related brain injury
ABSTRACT Cancer-related cognitive impairment (CRCI), often referred as “chemobrain”, is prevalent up to 75% of all breast cancer survivors. These impairments cause significant dist...
Feasibility of artesunate to improve HPV and cervical precancer treatment outcomes among HIV positive women in LMICs
ABSTRACT Women living in low- and middle-income countries (LMICs) face a disproportionate burden of incidence and mortality from cervical cancer, accounting for 85% of incident cas...
Evaluation of Pre-Analytical Factors of Urine Samples for Urine Cancer Cell Cultures (UCCC) --A Non-Invasive Biomarker – in Monitoring Response and Recurrence of Bladder Cancer
PROJECT SUMMARY Bladder cancer is one of the top 10 most frequent cancers, yet the most underfunded cancer by NCI based on funding dollars and ratio of funding/mortality. There has...
Methods for Fast and Efficient Oxygen Imaging
Abstract Intermittent or acute/cyclic hypoxia in tumors, with frequencies between a few cycles per minute to hours, is receiving increased attention because this type of hypoxia ha...
Leveraging the Hidden Genome to Recover the Missing Heritability of Cancer
PROJECT SUMMARY Decades of research into the genetic epidemiology of cancer have led to much knowledge about the heritability of the disease. However, findings have largely focused...
Promoting a Culture Of Innovation, Mentorship, Diversity and Opportunity in NCI Sponsored Clinical Research: NCI Research Specialist (Clinician Scientist) Award Application of Janice M. Mehnert, M.D.
Janice M. Mehnert, M.D., is the Associate Director (AD) for Clinical Research, Director, Melanoma and Cutaneous Oncology and a tenured Professor of Medicine at the Perlmutter Cance...
Time-lapse Flow Cytometry for Kinetic Profiling of T-Cell Function
Abstract Despite progress in immunotherapies, there are significant challenges to overcome to make them more broadly applicable to different cancers and more effective for patients...
Comprehensive Analysis of Best Practices for Clinical Testing of Malignant Pleural Effusion Specimens
PROJECT SUMMARY/ABSTRACT Patients with advanced cancers often develop malignant pleural effusions (MPEs), a collection of fluid that develops between the surface of the lung and th...
Clinical Trials Specialist in Developmental Therapeutics
Project Summary The planned activities describe a set of efforts that will build upon my interest in developmental therapeutics and childhood leukemias. I will lead a team of physi...
Time-lapse Flow Cytometry for Kinetic Profiling of T-Cell Function
Abstract Despite progress in immunotherapies, there are significant challenges to overcome to make them more broadly applicable to different cancers and more effective for patients...
Comprehensive Analysis of Best Practices for Clinical Testing of Malignant Pleural Effusion Specimens
PROJECT SUMMARY/ABSTRACT Patients with advanced cancers often develop malignant pleural effusions (MPEs), a collection of fluid that develops between the surface of the lung and th...
Develop Conditionally Armored CAR Macrophage Therapy for Pancreatic Cancer
SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with limited therapeutic options. About 95% PDAC patients harbor oncogenic mutant KRAS (KRA...
Promoting a Culture Of Innovation, Mentorship, Diversity and Opportunity in NCI Sponsored Clinical Research: NCI Research Specialist (Clinician Scientist) Award Application of Janice M. Mehnert, M.D.
Janice M. Mehnert, M.D., is the Associate Director (AD) for Clinical Research, Director, Melanoma and Cutaneous Oncology and a tenured Professor of Medicine at the Perlmutter Cance...
Defining therapeutic strategies for boosting T-cell infiltration into cold tumors with spatial proteomics and machine learning
Project Summary Immunotherapies such as immune checkpoint inhibitors and chimeric antigen receptor (CAR-T) cell therapy have been highly successful in reversing cancer progression...
CAPRISA CASCADE Clinical Trials Network Clinical Research Site
Summary The Center for the AIDS Program of Research in South Africa (CAPRISA) CASCADE Clinical Trials Network Clinical Research Site, aims to provide clinical trial infrastructure...
Clinical Trials Specialist in Developmental Therapeutics
Project Summary The planned activities describe a set of efforts that will build upon my interest in developmental therapeutics and childhood leukemias. I will lead a team of physi...
Develop Conditionally Armored CAR Macrophage Therapy for Pancreatic Cancer
SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with limited therapeutic options. About 95% PDAC patients harbor oncogenic mutant KRAS (KRA...
CAPRISA CASCADE Clinical Trials Network Clinical Research Site
Summary The Center for the AIDS Program of Research in South Africa (CAPRISA) CASCADE Clinical Trials Network Clinical Research Site, aims to provide clinical trial infrastructure...
NCI Clinical Trial Research Strategy, Harnessing of Equity, and Implementation
PROJECT SUMMARY/ABSTRACT I am a female board-certified radiation oncologist and Professor at the University of California (UC), San Diego, in the Department of Radiation Medicine....