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20,252 grants found
Showing 2,941 – 2,960 of 20,252 grants
Understanding the impact of chemotherapy on breast cancer metastasis and immune function in the liver
Project Summary Despite treatment with neoadjuvant chemotherapy, 30-40% of patients diagnosed with early-stage triple- negative breast cancer (TNBC) develop metastasis and die of t...
Matricellular proteins of the CNN family as regulators of tumor-induced cachexia
Summary/Abstract Cancer-associated cachexia is a multifactorial syndrome characterized by the involuntary loss of body and skeletal muscle mass (with or without fat loss) that redu...
Targeting tumor and T cell DNA methylomes to improve CAR T cell therapies for diffuse midline glioma
SUMMARY/ABSTRACT While improvements in immune therapies have revolutionized treatments in some cancers, pediatric brain tumors are especially resistant to current immunotherapy tre...
Gut microbiota-related mechanisms that impact colorectal cancer risk after bariatric surgery
Abstract: Bariatric surgery, currently the most effective treatment for morbid obesity, has become increasingly common in the US. Besides substantial and sustained weight loss, bar...
Integrating multi-omics, imaging, and longitudinal data to predict radiation response in cervical cancer
PROJECT SUMMARY/ABSTRACT Cervical cancer is among the most common cancer diagnoses among women, and treatment failure of standard of care chemoradiation therapy (CRT) for locally a...
Enabling immunotherapy for high-risk Group 3 medulloblastoma via systems immunology
PROJECT SUMMARY / ABSTRACT The goal of this project is to dissect the immune evasion mechanisms and enable immunotherapy for children with high-risk Group 3 medulloblastoma (G3MB)...
Loss of Cell Identity as a Prerequisite for Breast Cancer Development
ABSTRACT Transcription Factor (TF) networks are critical in suppressing cancer development by maintaining cell identity. TF networks are hierarchically organized, with pioneer TFs...
Matricellular proteins of the CNN family as regulators of tumor-induced cachexia
Summary/Abstract Cancer-associated cachexia is a multifactorial syndrome characterized by the involuntary loss of body and skeletal muscle mass (with or without fat loss) that redu...
Understanding the impact of chemotherapy on breast cancer metastasis and immune function in the liver
Project Summary Despite treatment with neoadjuvant chemotherapy, 30-40% of patients diagnosed with early-stage triple- negative breast cancer (TNBC) develop metastasis and die of t...
Enabling immunotherapy for high-risk Group 3 medulloblastoma via systems immunology
PROJECT SUMMARY / ABSTRACT The goal of this project is to dissect the immune evasion mechanisms and enable immunotherapy for children with high-risk Group 3 medulloblastoma (G3MB)...
Targeting tumor and T cell DNA methylomes to improve CAR T cell therapies for diffuse midline glioma
SUMMARY/ABSTRACT While improvements in immune therapies have revolutionized treatments in some cancers, pediatric brain tumors are especially resistant to current immunotherapy tre...
A Scalable Continuous Production Platform for Large-Scale Manufacturing of Therapeutic Exosomes
Project Summary Exosomes are a subset of extracellular vesicles, with diameters between 30 and 200 nm, secreted by most eukaryotic cells. They deliver bioactive cargos, such as lip...
Deep Learning of Mass Spectrometry Imaging
PROJECT SUMMARY Mass spectrometry imaging (MSI) is a rapidly developing technology which gives pathologists many new types of targets (e.g., metabolites and lipids) to assess for t...
Integrating multi-omics, imaging, and longitudinal data to predict radiation response in cervical cancer
PROJECT SUMMARY/ABSTRACT Cervical cancer is among the most common cancer diagnoses among women, and treatment failure of standard of care chemoradiation therapy (CRT) for locally a...
Catalyzing Cancer Research among Urban Underrepresented Minority Youths and Teachers (CATALYST)
Project Summary West Baltimore is comprised of majority minority communities that are among the most economically and academically disadvantaged in the US and are disproprotionatel...
Catalyzing Cancer Research among Urban Underrepresented Minority Youths and Teachers (CATALYST)
Project Summary West Baltimore is comprised of majority minority communities that are among the most economically and academically disadvantaged in the US and are disproprotionatel...
Epigallocatechin gallate for prevention of lethal cirrhosis complications
Summary Hepatocellular carcinoma (HCC) is the leading cause of death in patients with cirrhosis, and the fastest rising cancer mortality in the U.S. Due to the limited efficacy of...
Evaluation of Pre-Analytical Factors of Urine Samples for Urine Cancer Cell Cultures (UCCC) --A Non-Invasive Biomarker – in Monitoring Response and Recurrence of Bladder Cancer
PROJECT SUMMARY Bladder cancer is one of the top 10 most frequent cancers, yet the most underfunded cancer by NCI based on funding dollars and ratio of funding/mortality. There has...
Feasibility of artesunate to improve HPV and cervical precancer treatment outcomes among HIV positive women in LMICs
ABSTRACT Women living in low- and middle-income countries (LMICs) face a disproportionate burden of incidence and mortality from cervical cancer, accounting for 85% of incident cas...
Neurotrophic strategy to mitigate chemotherapy-related brain injury
ABSTRACT Cancer-related cognitive impairment (CRCI), often referred as “chemobrain”, is prevalent up to 75% of all breast cancer survivors. These impairments cause significant dist...