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20,252 grants found
Showing 2,921 – 2,940 of 20,252 grants
CD 1530, an RAR Gamma Agonist for Oral Cavity Squamous Cell Carcinoma Prevention
Abstract Despite intensive treatments that often combine surgery, chemotherapy, and radiation, patients with head and neck squamous cell carcinomas (HNSCCs), including oral cavity...
The Role of Astrocyte Elevated Gene-1 (AEG-1), A Novel Multifunctional Protein, In Chemotherapy-Induced Peripheral Neuropathy
Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a prominent dose-limiting side effect of chemotherapy treatment and will often result in the discontinuation of a trea...
Multi-functional cellular therapies to overcome tumor heterogeneity and limit toxicity in acute myeloid leukemia
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is a devastating disease with only 30% 5-year overall survival. As a blood cancer, AML appears poised to benefit from the revo...
Multi-functional cellular therapies to overcome tumor heterogeneity and limit toxicity in acute myeloid leukemia
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is a devastating disease with only 30% 5-year overall survival. As a blood cancer, AML appears poised to benefit from the revo...
Development of ALM-488 for nerve and ureter visualization during abdominal surgery
PROJECT SUMMARY Fundamental to the goals of surgery are functional preservation of critical nerves and minimization of post- operative patient morbidity. Unfortunately, inadvertent...
Testing the efficacy of a decision aid and planning tool for family building after cancer
Project Summary/Abstract Up to 93% of young adult female (YA-F) cancer survivors report fertility distress; 30-46% meet criteria for moderate-severe fertility-related trauma. Gonad...
Development of ALM-488 for nerve and ureter visualization during abdominal surgery
PROJECT SUMMARY Fundamental to the goals of surgery are functional preservation of critical nerves and minimization of post- operative patient morbidity. Unfortunately, inadvertent...
Democratizing CAR T cell therapy by in situ programming of virus-specific T cells
Engineered T cells that express chimeric antigen receptors (CARs) have shown remarkable efficacy against hematological malignancies. However, broad implementation of CAR T cell the...
Impact of microbiota on AIDS-Kaposi’s sarcoma development and therapy
Project Abstract Microbiota imbalance impacts the development and therapeutic outcome of cancer by altering host immune response and inflammation. Kaposi’s sarcoma (KS) is the most...
Investigating the EBV methylome in PLWH: Discovery and Development of Novel EBV Diagnostics in Plasma and Saliva
ABSTRACT EBV(+) lymphomas are an important cause of death in people living with HIV (PLWH). Different patterns of viral and cellular gene expression have been found to characterize...
Testing the efficacy of a decision aid and planning tool for family building after cancer
Project Summary/Abstract Up to 93% of young adult female (YA-F) cancer survivors report fertility distress; 30-46% meet criteria for moderate-severe fertility-related trauma. Gonad...
Randomized Controlled Trial of Dyadic Financial Incentive Treatment for Dual Smoker Couples: Evaluation of Efficacy, Mechanisms, and Cost Effectiveness
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-032.” Couples where both members smoke (i.e. dual-smoker couples;...
Randomized Controlled Trial of Dyadic Financial Incentive Treatment for Dual Smoker Couples: Evaluation of Efficacy, Mechanisms, and Cost Effectiveness
Project Summary/Abstract Smokers partnered with other smokers (i.e., dual-smoker couples) represent ~2/3 of all smokers. Dual- smoker couples (DSCs) are less likely to try to quit...
Randomized Controlled Trial of Dyadic Financial Incentive Treatment for Dual Smoker Couples: Evaluation of Efficacy, Mechanisms, and Cost Effectiveness
Project Summary/Abstract Smokers partnered with other smokers (i.e., dual-smoker couples) represent ~2/3 of all smokers. Dual- smoker couples (DSCs) are less likely to try to quit...
Democratizing CAR T cell therapy by in situ programming of virus-specific T cells
Engineered T cells that express chimeric antigen receptors (CARs) have shown remarkable efficacy against hematological malignancies. However, broad implementation of CAR T cell the...
GPU-based SPECT Reconstruction Using Reverse Monte Carlo Simulations
Project Summary/Abstract Interest in applications of radiopharmaceutical conjugates has notably increased in the last few years for the treatment of a variety of cancers. These con...
Targeting DNA Mismatches for Auger Electron Radiotherapy
Project Summary/Abstract Mismatched DNA base pairs can arise due to polymerase errors or exposure to genotoxic chemicals. While eukaryotic cells have evolved a sophisticated mismat...
Impact of microbiota on AIDS-Kaposi’s sarcoma development and therapy
Project Abstract Microbiota imbalance impacts the development and therapeutic outcome of cancer by altering host immune response and inflammation. Kaposi’s sarcoma (KS) is the most...
Investigating the EBV methylome in PLWH: Discovery and Development of Novel EBV Diagnostics in Plasma and Saliva
ABSTRACT EBV(+) lymphomas are an important cause of death in people living with HIV (PLWH). Different patterns of viral and cellular gene expression have been found to characterize...
Gut microbiota-related mechanisms that impact colorectal cancer risk after bariatric surgery
Abstract: Bariatric surgery, currently the most effective treatment for morbid obesity, has become increasingly common in the US. Besides substantial and sustained weight loss, bar...