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20,252 grants found
Showing 2,901 – 2,920 of 20,252 grants
Immune Regulation of Dormancy at the Metastatic Site
PROJECT SUMMARY/ABSTRACT Patients with pancreatic ductal adenocarcinoma (PDAC) and no clinically detectable metastases are treated by surgery. However, >70% of such patients lat...
Role of Gut-Immune Interactions in Aging-Associated Bladder Cancer
ABSTRACT Bladder cancer (BCa) is predominantly a disease of aging with the risk of developing invasive disease peaking in the 8th decade of life. Elderly patients have higher rates...
Investigating mitochondrial dysfunction in high-risk prostate cancer
Project Summary/Abstract Prostate cancer incidence in the United States has significantly increased over the last two decades. Despite the improvement of screening strategies, it r...
Psycho-Spiritual Management for Patients with Advanced Cancer and their Family Caregivers
PROJECT SUMMARY/ABSTRACT Given the generally incurable nature of metastatic cancer, patients and their family caregivers are at high risk of experiencing depressive symptoms and sp...
Theranostic for gastric cancer
Project Summary The overarching objective of this application is to develop an image-guided therapy paradigm for improving the management of gastric cancer (GCa) by targeting fibri...
Base Title: PREVENT Preclinical Drug Development Program: Preclinical Efficacy and Intermediate Endpoint BiomarkersTask Order Title: Colorectal Cancer (CRC) Prevention by TPST-1495 in PIRC rat mod
The purpose of this Task Order is to evaluate the efficacy and preliminary safety of TPST-1495 for the prevention of Colorectal Cancer (CRC) associated with Familial Adenomatous Po...
TOPIC 423 (PHASE II): AN INTEGRATED MULTI-LEVEL DECISION SUPPORT PLATFORM TO ADDRESS PATIENT-CENTERED AND EVIDENCE-BASED SOCIAL DETERMINANTS OF HEALTH AMONG CANCER PATIENTS.
A strong body of evidence suggests that addressing Social Determinants of Health (SDH) within healthcare systems advances cancer treatment adherence and reduces disparities in outc...
SELENOF is a Novel Tumor Suppressor and a New Target to Overcome Racial Disparity in Breast Cancer.
Project Summary / Abstract This proposal addresses the challenge of closing the racial disparity gap in breast cancer mortality by identifying a contributing biological factor and...
Prognostic Radiomic Signatures in Prostate Cancer Patients on Active Surveillance
PROJECT SUMMARY/ABSTRACT With prostate cancer (PCa) being among the most common cancers in men worldwide (estimated 1,600,000 cases, 366,000 deaths annually), the need for new biom...
Deep phenotyping of fusion oncoprotein-driven pediatric cancer metastasis with single-cell proteomics
SOW/Abstract: The proposed research for the NIH New Innovator Award seeks to biochemically and biophysically characterize complete cytoskeletal phenotypes of metastatic fusion onco...
Theranostic for gastric cancer
Project Summary The overarching objective of this application is to develop an image-guided therapy paradigm for improving the management of gastric cancer (GCa) by targeting fibri...
R25 YES: Cancer Research Opportunities at Iowa
Houtman/Lubaroff Summary/Abstract Underrepresented (UR) populations are less likely to obtain advanced degrees in the field of cancer research. In an attempt to address this proble...
Attacking the Immunopeptidome of Ewing Sarcoma
PROJECT SUMMARY Solid cancers are a leading cause of cancer related death in children and there is great interest in harnessing recent progress in immunotherapy for the treatment o...
Prognostic Radiomic Signatures in Prostate Cancer Patients on Active Surveillance
PROJECT SUMMARY/ABSTRACT With prostate cancer (PCa) being among the most common cancers in men worldwide (estimated 1,600,000 cases, 366,000 deaths annually), the need for new biom...
Psycho-Spiritual Management for Patients with Advanced Cancer and their Family Caregivers
PROJECT SUMMARY/ABSTRACT Given the generally incurable nature of metastatic cancer, patients and their family caregivers are at high risk of experiencing depressive symptoms and sp...
SELENOF is a Novel Tumor Suppressor and a New Target to Overcome Racial Disparity in Breast Cancer.
Project Summary / Abstract This proposal addresses the challenge of closing the racial disparity gap in breast cancer mortality by identifying a contributing biological factor and...
Topic 447: Development and testing of a non-invasive cryo-device to prevent chemotherapy-induced peripheral neuropathy in hands and feet of cancer patients receiving Taxol for breast cancer.
The objective of this proposal is to develop a prototype device capable of cooling extremities to a level sufficient for prevention of chemotherapy-induced peripheral neuropathy (C...
CD 1530, an RAR Gamma Agonist for Oral Cavity Squamous Cell Carcinoma Prevention
Abstract Despite intensive treatments that often combine surgery, chemotherapy, and radiation, patients with head and neck squamous cell carcinomas (HNSCCs), including oral cavity...
R25 YES: Cancer Research Opportunities at Iowa
Houtman/Lubaroff Summary/Abstract Underrepresented (UR) populations are less likely to obtain advanced degrees in the field of cancer research. In an attempt to address this proble...
Attacking the Immunopeptidome of Ewing Sarcoma
PROJECT SUMMARY Solid cancers are a leading cause of cancer related death in children and there is great interest in harnessing recent progress in immunotherapy for the treatment o...