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20,252 grants found
Showing 2,881 – 2,900 of 20,252 grants
Role of Gut-Immune Interactions in Aging-Associated Bladder Cancer
ABSTRACT Bladder cancer (BCa) is predominantly a disease of aging with the risk of developing invasive disease peaking in the 8th decade of life. Elderly patients have higher rates...
Mechanical properties of adipose tissue and its effect on breast cancer
PROJECT SUMMARY We recently discovered an unexpected and intriguing role for white adipose tissue (WAT) in breast cancer. Our past studies identified that the mechanical properties...
Screening strategies and social determinants of health among people with high risk of anal cancer
Abstract: The incidence of anal cancer has almost doubled during the past decades, along with increased advanced disease and mortality. Persistent high-risk human papillomavirus (h...
DNA repair dysfunction in cancer induced by altered BRCA2 localization
PROJECT SUMMARY/ABSTRACT BRCA2, as part of the DNA repair pathway, is a key regulator in homology-directed repair (HDR) and fork protection mechanism, which ensures genome instabil...
Visual Analytics for Exploration and Hypothesis Generation Using Highly MultiplexedSpatial Data of Tissues and Tumors
PROJECT SUMMARY The recent development of highly multiplexed subcellular resolution tissue imaging promises to accelerate research into tumor initiation, progression, and immune su...
CSHL 2023 Eukaryotic DNA Replication and Genome Maintenance Conference
2023 CSHL CONFERENCE ON EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE PROJECT SUMMARY/ABSTRACT This conference will be the 19th biennial meeting on Eukaryotic DNA Replication...
Perform non-GLP and GLP TOX/TK studies, and file a novel drug IND with the FDA for advanced pancreatic cancer patient clinical trials
Abstract/Summary The goals of this SBIR Phase I grant are: (1) to use the clinically compatible FL118 product to perform the non- good laboratory practice (GLP) and GLP toxicology...
From pathogenesis to new therapeutic targets in diffuse large B cell lymphoma
PROJECT SUMMARY Diffuse Large B cell Lymphoma (DLBCL) is incurable in ~30% of patients and, despite recent advances in CAR- T cell therapies, remains a significant clinical challen...
Screening strategies and social determinants of health among people with high risk of anal cancer
Abstract: The incidence of anal cancer has almost doubled during the past decades, along with increased advanced disease and mortality. Persistent high-risk human papillomavirus (h...
Development and Pre-Clinical Validation of Quantitative Imaging of Cell State Kinetics (QuICK) for Functional Precision Oncology
PROJECT ABSTRACT Functional precision oncology is the practice of assessing the phenotype of biopsied tumor cells upon perturbation, e.g. treatment with candidate therapies, to yie...
Immune Regulation of Dormancy at the Metastatic Site
PROJECT SUMMARY/ABSTRACT Patients with pancreatic ductal adenocarcinoma (PDAC) and no clinically detectable metastases are treated by surgery. However, >70% of such patients lat...
DNA repair dysfunction in cancer induced by altered BRCA2 localization
PROJECT SUMMARY/ABSTRACT BRCA2, as part of the DNA repair pathway, is a key regulator in homology-directed repair (HDR) and fork protection mechanism, which ensures genome instabil...
Mapping the single cell state basis of metastasis in space and time
We propose to leverage recent advances in machine learning and systems biology to enable high dimensional molecular assessment of the dynamic cell state transitions driving metasta...
Visual Analytics for Exploration and Hypothesis Generation Using Highly MultiplexedSpatial Data of Tissues and Tumors
PROJECT SUMMARY The recent development of highly multiplexed subcellular resolution tissue imaging promises to accelerate research into tumor initiation, progression, and immune su...
Evaluating the impact of obesity associated fatty acid metabolic dysregulation on breast cancer sensitivity to ferroptosis
Project Abstract Breast cancer remains the second-leading cause of cancer-related death in the US. Obesity is an established risk factor for several aggressive breast cancer subtyp...
IMAT-ITCR Collaboration: Multiplexed Spatial Data calibration and analysis using micro-capsules
PROJECT SUMMARY Highly multiplexed imaging methods such as CycIF, CODEX, mxIF, MIBI, and IMC are providing remarkable insight into tumor micro-environments, but they suffer from su...
Mechanical properties of adipose tissue and its effect on breast cancer
PROJECT SUMMARY We recently discovered an unexpected and intriguing role for white adipose tissue (WAT) in breast cancer. Our past studies identified that the mechanical properties...
From pathogenesis to new therapeutic targets in diffuse large B cell lymphoma
PROJECT SUMMARY Diffuse Large B cell Lymphoma (DLBCL) is incurable in ~30% of patients and, despite recent advances in CAR- T cell therapies, remains a significant clinical challen...
Development and Pre-Clinical Validation of Quantitative Imaging of Cell State Kinetics (QuICK) for Functional Precision Oncology
PROJECT ABSTRACT Functional precision oncology is the practice of assessing the phenotype of biopsied tumor cells upon perturbation, e.g. treatment with candidate therapies, to yie...
Mapping the single cell state basis of metastasis in space and time
We propose to leverage recent advances in machine learning and systems biology to enable high dimensional molecular assessment of the dynamic cell state transitions driving metasta...