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20,252 grants found
Showing 2,861 – 2,880 of 20,252 grants
Targeting MALT1 to Enhance Anti-Lymphoma Immunity and Response to Immunotherapy
ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is the most frequent B-cell non-Hodgkin lymphoma (B-NHL). The treatment of these diseases remains challenging, with many patients ult...
A Phase 2, randomized, double-blind, 4-arm, multicenter study to demonstrate the efficacy and safety of topical dosage formulations of a prescription drug product for actinic keratosis
PROJECT SUMMARY / ABSTRACT Acinic Keratoses (AK) are premalignant skin lesions with the potential to develop into Cutaneous Squamous cell Carcinoma (CSCC), which is the second most...
A Bioprinted Volumetric Model of Vascularized Glioblastoma
Abstract The dynamic tumor microenvironment (TME) where cells continuously communicate, migrate, and react to each other and the signals that are secreted, is critical for inducing...
Developing and Automating an Extracellular Vesicle-Based Test for Early Detection of Hepatocellular Carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) comprises 80-85% of primary liver cancers and frequently develops in patients with liver cirrhosis or chronic hepatitis B virus infec...
Training Grant in Precision Cancer Control
PROJECT SUMMARY In the United States, more than 40 percent of new cancer cases can be attributed to modifiable factors. Yet, despite advances in knowledge regarding the multilevel...
Dissecting the role of mitochondrial glutathione homeostasis in cancer
Project Summary All eukaryotic cells, whether normal or cancerous, require the ability to sense changes in nutrients levels, ensuring their efficient use for survival and growth. N...
Summer Program for Academic Research in Cancer (SPARC)
The objective of the proposed Summer Program for Academic Research in Cancer (SPARC) at the Indiana University Simon Comprehensive Cancer Center (IUSCCC) is to provide cancer resea...
University of Kansas Cancer Center Paul Calabresi K12 Career Development Award for Clinical Oncology
ABSTRACT We propose to develop The University of Kansas Cancer Center (KUCC) Paul Calabresi K12 Career Development Award for Clinical Oncology (“KUCC K12 Program”), whose primary g...
Optimizing prostate cancer care: integrating risks, benefits, and patient experiences in the new era of molecular imaging
PROJECT SUMMARY/ABSTRACT A molecular imaging revolution is underway in prostate cancer. To overcome longstanding limitations in prostate cancer staging, several positron-emission t...
Examining the effects of Global Budget Revenue Program on the Costs and Quality of Care Provided to Cancer Patients Undergoing Chemotherapy
Project Summary/Abstract In 2014, the state of Maryland, under a federal waiver, enacted an all-payer Global Budget Revenue (GBR) model that prospectively set limits on hospital re...
Transposable Elements at the Crossroads of Evolution, Health and Disease
ABSTRACT Support is requested for a Keystone Symposia conference entitled Transposable Elements at the Crossroads of Evolution, Health and Disease, organized by Drs. Kathleen Burns...
Measuring Gender in the Healthy Oregon Project
PROJECT SUMMARY The sexual and gender minority (SGM) community (i.e., LGBTQ+) is vastly underrepresented in cancer research. As such, there are limited data on cancer-related healt...
Cloud Enabled, Rigorous, Functional Assay Calibration (CERFAC)
SUMMARY The use of gene sequencing to identify pathogenic sequence variants of high-risk disease susceptibility genes began in the mid-late 1990s. In about 2010, the technology use...
Summer Program for Academic Research in Cancer (SPARC)
The objective of the proposed Summer Program for Academic Research in Cancer (SPARC) at the Indiana University Simon Comprehensive Cancer Center (IUSCCC) is to provide cancer resea...
Optimizing prostate cancer care: integrating risks, benefits, and patient experiences in the new era of molecular imaging
PROJECT SUMMARY/ABSTRACT A molecular imaging revolution is underway in prostate cancer. To overcome longstanding limitations in prostate cancer staging, several positron-emission t...
University of Kansas Cancer Center Paul Calabresi K12 Career Development Award for Clinical Oncology
ABSTRACT We propose to develop The University of Kansas Cancer Center (KUCC) Paul Calabresi K12 Career Development Award for Clinical Oncology (“KUCC K12 Program”), whose primary g...
Examining the effects of Global Budget Revenue Program on the Costs and Quality of Care Provided to Cancer Patients Undergoing Chemotherapy
Project Summary/Abstract In 2014, the state of Maryland, under a federal waiver, enacted an all-payer Global Budget Revenue (GBR) model that prospectively set limits on hospital re...
A phase-1 trial of intraperitoneal 5-fluorouracil and oxaliplatin in patients with colorectal cancer and unresectable peritoneal metastasis.
SUMMARY Patients with colorectal cancer (CRC) and peritoneal metastases (PM) have significantly worse outcomes than metastases to other sites like the lungs or liver. In patients w...
Ovarian cancer risk stratification using circulating miRNAs to assess BRCAness
Abstract Current strategies to prevent ovarian cancer deaths remain limited. Unlike breast and colon cancer, clinical trials for early detection of ovarian cancer have not been eff...
Investigating mitochondrial dysfunction in high-risk prostate cancer
Project Summary/Abstract Prostate cancer incidence in the United States has significantly increased over the last two decades. Despite the improvement of screening strategies, it r...