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20,252 grants found
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Product Evaluation and Manipulation Core (PEMC)
PROJECT SUMMARY – PRODUCT EVALUATION AND MANIPULATION CORE The goal of the Product Evaluation and Manipulation Core (PEMC) is to support and complement the human research conducted...
Marketing Monitoring Core (MMC)
PROJECT SUMMARY – MARKET MONITORING CORE The landscape of the tobacco market continues to increase in complexity by product and design, with the intent to maintain tobacco use and...
Mitochondrial Dysfunction underlies treatment related hepatotoxicity in Hispanics with acute lymphoblastic leukemia
PROJECT TITLE: Mitochondrial dysfunction underlies treatment related hepatotoxicity in Hispanics with acute lymphoblastic leukemia ABSTRACT: Acute Lymphoblastic leukemia is the mos...
HARNESSING IN VIVO CLICK CHEMISTRY FOR 211AT-BASED PRETARGETED RADIOIMMUNOTHERAPY
PROJECT SUMMARY/ABSTRACT Over the last fifteen years, radioimmunotherapy (RIT) using antibodies labeled with a-emitting radionuclides has shown significant promise for the treatmen...
Minimally invasive quantitative tissue oxygen sensors to personalize cancer care
Project Summary and Abstract Hypoxic (oxygen depleted) tumors are more resistant to treatments including radiation therapy. This trend has been seen across a wide range of cancers...
A Multi-Institute Survivorship Study of Patients Living with Advanced Cancer Who Have Had Durable Response to Immune Checkpoint Inhibitors
ABSTRACT Immune checkpoint inhibitors (ICIs) have markedly transformed the therapeutic landscape for many types of advanced malignancies over the past decade. A sizable proportion...
A Bioprinted Volumetric Model of Vascularized Glioblastoma
Abstract The dynamic tumor microenvironment (TME) where cells continuously communicate, migrate, and react to each other and the signals that are secreted, is critical for inducing...
Targeting MALT1 to Enhance Anti-Lymphoma Immunity and Response to Immunotherapy
ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is the most frequent B-cell non-Hodgkin lymphoma (B-NHL). The treatment of these diseases remains challenging, with many patients ult...
A Phase 2, randomized, double-blind, 4-arm, multicenter study to demonstrate the efficacy and safety of topical dosage formulations of a prescription drug product for actinic keratosis
PROJECT SUMMARY / ABSTRACT Acinic Keratoses (AK) are premalignant skin lesions with the potential to develop into Cutaneous Squamous cell Carcinoma (CSCC), which is the second most...
Developing and Automating an Extracellular Vesicle-Based Test for Early Detection of Hepatocellular Carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) comprises 80-85% of primary liver cancers and frequently develops in patients with liver cirrhosis or chronic hepatitis B virus infec...
Project 1: Manipulating E-cigarette Nicotine to Promote Public Health
PROJECT SUMMARY – PROJECT 1 Historically, the tobacco industry manipulated nicotine in cigarettes to promote smoking. They are now following the same playbook for e-cigarettes (ECs...
Project 2: Informing oral nicotine pouch regulations to promote public health
PROJECT SUMMARY – PROJECT 2 Historically, the tobacco industry manipulated nicotine concentration and form to offer a range of smokeless tobacco (ST) products to appeal to both new...
Project 3: Nicotine Product Claims on Appeal, Perceptions, and Use Behavior
SUMMARY – PROJECT 3 Oral nicotine pouches (ONPs) emerged in the U.S. in 2016, ONP brands rapidly proliferated, and sales are skyrocketing. ONPs are representative of a shift by the...
Project 4: A Naturalistic Observation of Electronic Cigarettes and Oral Nicotine Pouch Product Use Among Adolescents and Young Adults
PROJECT SUMMARY – PROJECT 4 The tobacco product landscape changed drastically in the last decade with the proliferation of non-combustible tobacco products like e-cigarettes (ECs)...
Administrative Core (AC)
PROJECT SUMMARY - ADMINISTRATIVE CORE The Administrative Core (AC) will provide a structure to facilitate effective and integrative interactions between the TCORS team. The AC will...
Career Enhancement Core
PROJECT SUMMARY - CAREER ENHANCEMENT CORE The goal of the Career Enhancement Core (CEC) is to foster the development of researchers planning to engage in the field of tobacco regul...
Product Evaluation and Manipulation Core (PEMC)
PROJECT SUMMARY – PRODUCT EVALUATION AND MANIPULATION CORE The goal of the Product Evaluation and Manipulation Core (PEMC) is to support and complement the human research conducted...
Marketing Monitoring Core (MMC)
PROJECT SUMMARY – MARKET MONITORING CORE The landscape of the tobacco market continues to increase in complexity by product and design, with the intent to maintain tobacco use and...
A Multi-Institute Survivorship Study of Patients Living with Advanced Cancer Who Have Had Durable Response to Immune Checkpoint Inhibitors
ABSTRACT Immune checkpoint inhibitors (ICIs) have markedly transformed the therapeutic landscape for many types of advanced malignancies over the past decade. A sizable proportion...
Immune control of oncogene selection in preneoplastic colon
Colon cancers develop by stepwise accumulation of oncogenic mutations in epithelial stem cells. These mutated stem cells multiply by positive selection in healthy colon for years b...