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20,252 grants found
Showing 2,821 – 2,840 of 20,252 grants
A Healthy Weight Intervention for Family Stress during the Early Phases of ALL Treatment: NOURISH-ALL
PROJECT SUMMARY/ABSTRACT Excessive weight gain leading to obesity is common during the early phases of pediatric acute lymphoblastic leukemia (ALL) treatment, and results in higher...
Oncology-focused Postdoctoral Training in Care Delivery and Symptom Science (OPTICS)
PROJECT SUMMARY/ABSTRACT The Oncology-focused Postdoctoral Training In Care Delivery and Symptom Science (OPTICS) T32 program will mentor and train physicians and scientists with P...
Graduate Program in Cancer Biology Training at Emory University
PROJECT SUMMARY Cancer represents a collection of diseases that remains the second leading cause of death in the United States. However, several recent advances in cross-disciplina...
Advanced development of composite gene delivery and CAR engineering systems
SUMMARY | Cellular immunotherapy such as chimeric antigen receptor (CAR) T cells involves engineering and adoptive transfer of cells to directly target tumor cells in patient, and...
Project 1: Deciphering the Dynamic Evolution of the Tumor-Neural Interface
ABSTRACT – PROJECT 1 The central premise of our CSBC MIT/DFCI Center for Systems Biology in Glioblastoma is that high-content systems-level measurements at molecular, microscopic,...
Project 2: Deciphering the Dynamic Evolution of the Tumor-Immune Interface
ABSTRACT – PROJECT 2 The central premise of our CSBC MIT/DFCI Center for Systems Biology in Glioblastoma is that high-content systems-level measurement techniques, employed across...
Immune control of oncogene selection in preneoplastic colon
Colon cancers develop by stepwise accumulation of oncogenic mutations in epithelial stem cells. These mutated stem cells multiply by positive selection in healthy colon for years b...
Dissecting the role of mitochondrial glutathione homeostasis in cancer
Project Summary All eukaryotic cells, whether normal or cancerous, require the ability to sense changes in nutrients levels, ensuring their efficient use for survival and growth. N...
Development of a new class of BLVRB-targeted redox therapeutics in breast cancer
SUMMARY Enhanced metabolic and mitochondrial activity inherent in actively proliferating cancer cells generates an excessive amount of reactive oxygen species (ROS), associated wit...
Targeting pancreatic cancer metastases with Targefrin
ABSTRACT We intend to devise a novel therapeutic strategy based on a specific cancer cell receptor named EphA2, which is abundant on the surface of metastatic pancreatic cancers. O...
Training Grant in Precision Cancer Control
PROJECT SUMMARY In the United States, more than 40 percent of new cancer cases can be attributed to modifiable factors. Yet, despite advances in knowledge regarding the multilevel...
The Ohio State University Tobacco Center of Regulatory Science (OSU-TCORS)
OVERALL PROJECT SUMMARY Nicotine is the most important driver of tobacco use. The tobacco industry's manipulation of nicotine in cigarettes and smokeless tobacco led to produc...
Targeting tumor cell macrophage lipid interactions to overcome resistance to androgen receptor targeted therapy
Abstract Tumor-associated macrophages are key effector immune cells that promote prostate cancer progression. Studies in other cancers show that macrophage secrete cytokines, angio...
The Ohio State University Tobacco Center of Regulatory Science (OSU-TCORS)
OVERALL PROJECT SUMMARY Nicotine is the most important driver of tobacco use. The tobacco industry's manipulation of nicotine in cigarettes and smokeless tobacco led to produc...
Project 1: Manipulating E-cigarette Nicotine to Promote Public Health
PROJECT SUMMARY – PROJECT 1 Historically, the tobacco industry manipulated nicotine in cigarettes to promote smoking. They are now following the same playbook for e-cigarettes (ECs...
Project 2: Informing oral nicotine pouch regulations to promote public health
PROJECT SUMMARY – PROJECT 2 Historically, the tobacco industry manipulated nicotine concentration and form to offer a range of smokeless tobacco (ST) products to appeal to both new...
Project 3: Nicotine Product Claims on Appeal, Perceptions, and Use Behavior
SUMMARY – PROJECT 3 Oral nicotine pouches (ONPs) emerged in the U.S. in 2016, ONP brands rapidly proliferated, and sales are skyrocketing. ONPs are representative of a shift by the...
Project 4: A Naturalistic Observation of Electronic Cigarettes and Oral Nicotine Pouch Product Use Among Adolescents and Young Adults
PROJECT SUMMARY – PROJECT 4 The tobacco product landscape changed drastically in the last decade with the proliferation of non-combustible tobacco products like e-cigarettes (ECs)...
Administrative Core (AC)
PROJECT SUMMARY - ADMINISTRATIVE CORE The Administrative Core (AC) will provide a structure to facilitate effective and integrative interactions between the TCORS team. The AC will...
Career Enhancement Core
PROJECT SUMMARY - CAREER ENHANCEMENT CORE The goal of the Career Enhancement Core (CEC) is to foster the development of researchers planning to engage in the field of tobacco regul...