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20,252 grants found
Showing 261 – 280 of 20,252 grants
Defining Novel Redox Stress Mechanisms to Inhibit KRAS-driven Pancreatic Ductal Adenocarcinoma
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths with a 5-year survival rate of 12%. Over 90% of PDAC is driven by oncogenic KRAS, howeve...
Understanding Kras Mutation Heterogeneity in PDAC
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent neoplastic disease of the pancreas, and it is expected to become the second leading cause of cancer re...
Engineering the Premetastatic Niche
Project Summary The majority of breast cancer related deaths occur as a result of metastasis. Once the cancer cells metastasize, the 5-year relative survival rate for breast cancer...
Evaluation of combination CLK/DYRK (Cirtuvivint) inhibition with PARP inhibition (Olaparib) in BRCA/HRD platinum resistant ovarian cancer
PROJECT SUMMARY/ABSTRACT Approximately 50% of patients with ovarian cancer harbor deficiencies in DNA damage repair with either a germline/somatic mutation in BRCA1/2 or homologous...
Dissecting the immunomodulatory effects of NK cells on immune responses to cancer
PROJECT SUMMARY Current immunotherapies, such as anti-PD-1 immunotherapy, have low objective responses in patients, necessitating the development of novel therapies that boost immu...
Investigating the mechanism of K17-mediated immunosuppression in papillomavirus-induced cancers
PROJECT SUMMARY/ABSTRACT My long-term career goal is to become an independent scientist in an academic research institution. My research interest focuses on investigating novel mol...
Effects of a telehealth exercise program for rural cancer survivors with cancer-related fatigue including integrated longitudinal assessments of objective physical function and fatty acid oxidation
PROJECT ABSTRACT Cancer-related fatigue (CRF) is one of the most common and functionally limiting symptoms reported by cancer survivors. While no standard of care exists for CRF ma...
Harnessing digital health and equity informed multi-level implementation strategies to promote uptake of depression treatment in cancer settings: iCan DepCare
Cancer patients with elevated depressive symptoms have higher rates of cancer mortality, recurrence, diminished quality of life (QoL), healthcare expenditure, and chemotherapy nona...
Assessing the efficacy of a ROR1:PD-L1:CD2 multispecific T cell engager in ROR1-positive and -negative neuroblastoma models
PROJECT SUMMARY/ABSTRACT Few children with recurrent neuroblastoma survive. New therapies, particularly immunotherapies, are badly needed. Some promising results have recently been...
Adapting and testing a smoking cessation intervention for transgender and gender-diverse individuals
Despite the substantial decrease in the prevalence of smoking over the past 50-years, there are persistent and significant disparities in tobacco use among transgender and gender d...
A Virtual, Group-Based, Expressive Writing Intervention for Survivors of Adolescent and Young Adult Cancer
PROJECT SUMMARY/ABSTRACT Adolescent and young adult cancer survivors (AYACSs) face multiple disparities, including impaired psychosocial health, isolation, limited access to psycho...
Piloting an Implementation Strategy for Mainstream Genetic Testing in Colorectal Cancer
PROJECT SUMMARY Of the 150,000 individuals diagnosed with colorectal cancer (CRC) each year, 15% will carry a hereditary pathogenic germline variant (PGV) including some associated...
Preventing Cervical Cancer through HPV Self-collection and Patient Navigation among Women Living with Chronic Conditions and Social Vulnerability
PROJECT SUMMARY/ABSTRACT Despite advances across the cervical cancer care continuum – screening, treatment, and survivorship care, women with social vulnerability (i.e. poverty, ru...
Using Single-cell and Spatial Multi-omics to Improve Adoptive Cell Therapy against Pancreatic Cancer
Project Summary/Abstract Adoptive T cell therapy (ACT) has been effective against certain blood cancers but has had limited success against solid tumors, such as pancreatic cancers...
Development of a pre-clinical syngeneic pig glioma model for research and translational studies
Glioblastoma (GBM) is uniformly fatal with an incidence rate of 2.99-3.23 per 100,000 people. Despite recent therapeutic advances, our understanding of tumor biology in GBM remains...
Dietary lipids as drivers and therapeutic targets in obesity-accelerated breast cancer
Summary Diet-induced obesity affects about 40 percent of US women and increases the incidence, morbidity, and mortality of postmenopausal breast cancer (BC). Obesity also increases...
Vaping Cessation among youth: Evaluating the feasibility and efficacy of a virtual in-person CBT and an app-based CBT4CBT
PROJECT ABSTRACT E-cigarettes are the most popular nicotine-delivery devices used by US adolescents. Many adolescents do not like being addicted to e-cigarettes and want to quit. H...
Activation of SLFN12 RNase Activity by Dimerization
Velcrin compounds kill cancer cells expressing elevated levels of PDE3A and SLFN12 by inducing complex formation between these two proteins. Velcrin-induced PDE3A-SLFN12 complexes...
Director Genomics Shared Resource
PROJECT SUMMARY / ABSTRACT The current application seeks salary support for Prashant K. Singh, PhD who serves as the Director of the Genomics Shared Resource (GSR) at Roswell Park...
Artificial Intelligence for effective communication to promote vaping cessation on social media
PROJECT SUMMARY The National Youth Tobacco Survey showed the prevalence of e-cigarette use among high school students has skyrocketed from 12% in 2017 to 28% in 2019 and remains hi...