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20,252 grants found
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Defining the changing microbiome composition and host-microbe mechanistic effects following Apc inactivation during colorectal cancer pathogenesis
Project Summary Globally, colorectal cancer (CRC) is the second leading cause of cancer-related deaths in men and women and is projected to increase by 70% in the next 20-years. On...
Advanced development of composite gene delivery and CAR engineering systems
SUMMARY | Cellular immunotherapy such as chimeric antigen receptor (CAR) T cells involves engineering and adoptive transfer of cells to directly target tumor cells in patient, and...
Racially-associated MRI analysis and modeling for predicting aggressive prostate cancer
PROJECT SUMMARY African American (AA) men have the highest incidence and mortality rate from prostate cancer (PCa) in the United States. Prostate multi-parametric MRI (mpMRI) is a...
Biomarker Validation in Pancreatic Cystic Neoplasms
Project Summary Pancreatic cystic neoplasm (PCN) represents a common incidental finding in the population. Branch-duct intraductal papillary mucinous neoplasms (IPMN), the most com...
Racial Disparities and Colorectal DNA Methylation- Driven Gene Expression
ABSTRACT Racial disparities in colorectal cancer (CRC) are widening. There are well-documented racial differences in anatomical location distribution of CRC. African Americans (AAs...
Quantitative systems biology of glioblastoma cells and their interactions with the neuronal and immunological milieu
ABSTRACT – OVERALL The primary focus of the MIT/DFCI Center for Systems Biology of Glioblastoma is to understand the intersections between neurons, immune cells, and tumor cells in...
Administrative Core
ABSTRACT - ADMINISTRATIVE CORE The overarching framework for this MIT/DFCI Center for Systems Biology of Glioblastoma is to use systems biology to define the dynamic evolution of t...
Project 1: Deciphering the Dynamic Evolution of the Tumor-Neural Interface
ABSTRACT – PROJECT 1 The central premise of our CSBC MIT/DFCI Center for Systems Biology in Glioblastoma is that high-content systems-level measurements at molecular, microscopic,...
Project 2: Deciphering the Dynamic Evolution of the Tumor-Immune Interface
ABSTRACT – PROJECT 2 The central premise of our CSBC MIT/DFCI Center for Systems Biology in Glioblastoma is that high-content systems-level measurement techniques, employed across...
Education and Outreach Core
ABSTRACT – EDUCATION AND OUTREACH CORE The scientific goal of our CSBC U54 MIT/DFCI Center for Systems Biology in Glioblastoma is to change the current paradigm in GBM research by...
Core 1: Biospecimens Core
ABSTRACT – BIOSPECIMENS CORE The Biospecimens Core will serve as a central resource to coordinate provision of highly translationally relevant animal and human analytical specimens...
Core 2: Analytical Core
ABSTRACT – ANALYTICAL CORE The Analytical Core will serve as a central resource for the deep systems-level molecular characterization of biological samples generated by the Project...
The Delta Ecology of NSCLC Treatment
Summary – Moffitt CSBC Proposal Overview The Moffitt CSBC proposal is focused on the essential and highly dynamical interplay between cancer cell evolution and the constantly chang...
Administrative Core
ADMINISTRATIVE CORE SUMMARY The Administrative Core remains a central component of the Moffitt CSBC. It has oversight of the disbursal of funds to the Projects and Cores. It is the...
Project 1: Delta immune Ecology of NSCLC
Summary – Project 1 Project 1 will study the ∆-Ecology of tumor-immune interactions in NSCLC, with a focus on KRAS-mutant cancers. Immunotherapy has demonstrated response rates of...
Project 2: Delta Stromal Ecology of NSCLC
Project 2 abstract Project 2 will investigate the changes in neoplastic and stromal compartments during the acquisition of resistance to ALK and KRAS targeting therapies, with spec...
Outreach Core
Summary Central to the Moffitt-CSBC Education core is an annual innovative, unique, and intense one-week interdisciplinary hands-on workshop to accelerate the training of the next...
Core 1: Mathematical Core
Summary – Mathematical Modeling Core Understanding the changes in tumor ecology (“∆-Ecology”) that occur during tumor initiation, progression, and therapy requires careful study of...
Core 2: Ecological Core
Summary – Ecological Core Recent advances in spatial ‘omics’ have led to an increased interest in studying and predicting emergent aggregate behavior and interactions between the t...
A novel dual-carrier ultrasmall nanomedicine for the treatment of stroma-rich pancreatic cancer
Abstract Pancreatic cancer (PC) has an annual worldwide incidence of more than 495,000 cases and an annual mortality rate of almost 460,000 cases. Most patients are diagnosed late...