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20,252 grants found
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MOSAIC: Data Integration and Computation Core
SUMMARY: DATA INTEGRATION AND COMPUTATION CORE A major challenge to any integrated, collaborative, multi-institutional effort is the centralized management and synthesis of shared...
Implementation of a qPCR-based assay for the quantification of SARS-CoV-2-specific T cells in immunocompromised patients
SUMMARY Long-term protection from viral infections is mediated by both the humoral and cellular immune pathways. Multiple Myeloma (MM) is the second most common hematological malig...
Mathematical Oncology Systems Analysis Imaging Center (MOSAIC)
SUMMARY: OVERALL: MATHEMATICAL ONCOLOGY SYSTEMS ANALYSIS IMAGING CENTER Glioblastoma (GBM), the most aggressive primary brain cancer, is amongst the most heterogeneous of cancers,...
Developing a novel combination immunotherapy for triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and has a very poor prognosis due to its tendency to metastasize and relapse. I...
Optimizing Carbon Ion Therapy for Pediatric CNS Tumors
SUMMARY Primary central nervous system (CNS) tumors are the most common solid tumors in children and the leading cause of childhood-cancer-related deaths. Thus, there is an urgent...
The role of extracellular matrix quality in the prediction of metastasis-induced skeletal fragility and response to immunotherapy
Metastatic bone disease (MBD) is a frequent and fatal complication in patients with advanced solid malignancies. Immune checkpoint inhibitors (ICIs) such as programmed cell death p...
COG NCTN Network Group Operations Center - Year 10 STAR Act COG) Outcomes & Survivorship (LTE) Committee
PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60-years ago, the prognosis of childhood cancer has improved dramatically....
SBIR TOPIC 401 PHASE II:
As long as breast cancer remains a pervasive health concern, the need for ever-improving breast cancer imaging and radiation therapy technologies will exist.Design changes – to inc...
Green Diversity Supplement: Predicting 5-ALA Fluorescence Status in High Grade Gliomas Based on MRI Features
Abstract High-grade gliomas (HGGs), such as glioblastoma multiforme (GBM), are notably aggressive, heterogeneous, and infiltrating brain tumors, presenting significant challenges i...
Multi-modal Liquid Biopsy Early Assessment of Breast Cancer, Pancreatic Cancer, and Multiple Myeloma
Abstract This Liquid Biopsy Research Laboratory (LBRL) will address specific unmet clinical needs in the early assessment of cancer by developing and validating multi-analyte liqui...
San Diego State University Advancing Cancer Careers for ExceLlence (ACCEL)
PROJECT SUMMARY / ABSTRACT San Diego State University’s Advancing Cancer Careers for ExceLlence (ACCEL) Program, in partnership with University of California San Diego (UCSD) Moore...
Elucidating mechanisms of checkpoint inhibitor-induced diabetes
Abstract: This K08 proposal will expedite the principal investigator’s progress towards her goal of becoming an independent physician-scientist with a focus on increasing our under...
MOSAIC: Imaging Human Tissue State Dynamics In Vivo
SUMMARY: PROJECT 2: IMAGING THE DYNAMIC TISSUE STATE IN PATIENTS IN VIVO With a dismal median survival of 16 months, glioblastoma (GBM) is the most common malignant primary brain t...
Outreach Core
SUMMARY: OUTREACH CORE The goals of the scientific portion of this proposal are directed towards bringing personalized medicine to the clinic for glioblastoma patients through inte...
MOSAIC: Biospecimen Core
SUMMARY: BIOSPECIMEN CORE The major objective of the Biospecimen Core is to obtain, process, image, and analyze glioblastoma (GBM) patients’ biopsies for use in both Projects of ou...
MOSAIC: Data Integration and Computation Core
SUMMARY: DATA INTEGRATION AND COMPUTATION CORE A major challenge to any integrated, collaborative, multi-institutional effort is the centralized management and synthesis of shared...
FY 2023 SBIR TOPIC 402 PHASE II. ENHANCE THE PERFORMANCE OF THE AI FOR LYMPH NODE DETECTION, SEGMENTATION AND MEASUREMENTS AND DEVELOP ADDITIONAL AI MODELS FOR MALIGNANCY CLASSIFICATION LEVERAGING MU
The correct determination of nodal metastatic disease is imperative for patient management in oncology, since the patient’s prognosis and subsequent treatment are inherently linked...
Clinician Scientist Supporting NCI-funded Clinical Trials at the Medical College of Wisconsin Cancer Center
PROJECT SUMMARY This application seeks partial salary support for a clinician scientist who is a highly accomplished clinical trialist in the Cancer Center at the Medical College o...
Defining the changing microbiome composition and host-microbe mechanistic effects following Apc inactivation during colorectal cancer pathogenesis
Project Summary Globally, colorectal cancer (CRC) is the second leading cause of cancer-related deaths in men and women and is projected to increase by 70% in the next 20-years. On...
DATA ANALYTICS, STATISTICAL AND BIOINFORMATIC ANALYSIS AND TOOL DEVELOPMENT, Genome wide association studies (GWAS)
TASK AREA C: DATA ANALYTICS, STATISTICAL AND BIOINFORMATIC ANALYSIS AND TOOL DEVELOPMENT, Genome wide association studies