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20,252 grants found
Showing 2,661 – 2,680 of 20,252 grants
Developing a culturally tailored mHealth symptom monitoring intervention to improve adherence to endocrine therapy among Black women with breast cancer
PROJECT SUMMARY Candidate Goals. My career goal is to reduce breast cancer health disparities in outcomes by addressing cancer care delivery issues in minority cancer populations....
MOSAIC: Administrative Core
SUMMARY: ADMINISTRATIVE CORE The overarching objective for the Mayo/Columbia MOSAIC CSBC is to build a conceptual framework to understand tissue state transitions that happen in gl...
THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCE
Project Summary The primary goal of our proposal is to improve the AI/ML-readiness of data in the Cancer Epitope Database and Analysis Resource (CEDAR). CEDAR provides a catalog of...
Gender-Affirming Testosterone Therapy on Breast Cancer Risk and Treatment Outcomes
This proposal will undertake preclinical studies to address breast cancer (BC) risk and treatment concerns of transmasculine people (female-to-male transition). This proposal will...
TOPIC 453: THE PERFECT MEDICAL ASSISTANT FOR CANCER PREVENTION WITHIN PRIMARY CARE
Cancer is the second leading and the most expensive cause of death in the United States. With more than 500 million visits a year made to primary care physicians, prevention and ea...
SERVICES FOR THE CHARACTERIZATION OF ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION, AND TOXICITY (ADMET) PROPERTIES OF SMALL-MOLECULE DRUG CANDIDATES USING STANDARDIZED IN VITRO METHODS IN SUPPORT O
The purpose of this contract is to determine in vitro ADMET (absorption, distribution, metabolism, excretion, toxicity) in two novel compounds using molecular methods.These experim...
Clinician Scientist in Leukemia
PROJECT SUMMARY / ABSTRACT This project is intended to support the applicant as a clinician-scientist in leukemia at Washington University School of Medicine / Siteman Cancer Cente...
Southwest Transformative Educational Advancement and Mentoring (STEAM) Network
PROJECT SUMMARY The Southwest Transformative Educational Advancement and Mentoring (STEAM) network leverages partnerships at the University of New Mexico (UNM), New Mexico State Un...
MOSAIC: Targeting the Tissue State
SUMMARY: PROJECT 1: TARGETING GLIOMA TISSUE STATES Glioblastoma (GBM) displays extensive cellular heterogeneity which represents a major obstacle for effective treatment. This cell...
Microsatellite Instability Sequencing via Single-Molecule DNA Re-Reading
Project Summary Oncologists have a great need for improved DNA sequencing technology because sequencing the DNA of cancer cells can provide valuable information about the specific...
Multi-modal Liquid Biopsy Early Assessment of Breast Cancer, Pancreatic Cancer, and Multiple Myeloma
Abstract This Liquid Biopsy Research Laboratory (LBRL) will address specific unmet clinical needs in the early assessment of cancer by developing and validating multi-analyte liqui...
Molecular Mechanisms of Wnt Transport
ABSTRACT Wnts are a family of evolutionary conserved, secreted ligands that act at short range to coordinate morphogenetic movements and cell fate decisions. Secretion of Wnt and s...
Optimizing Carbon Ion Therapy for Pediatric CNS Tumors
SUMMARY Primary central nervous system (CNS) tumors are the most common solid tumors in children and the leading cause of childhood-cancer-related deaths. Thus, there is an urgent...
Towards an inclusive genomic risk classification for acute myeloid leukemia (AML)
A. PROJECT SUMMARY Acute myeloid leukemia (AML) is the most common adult acute leukemia. Molecular features such as cytogenetics and somatic mutations are essential components of r...
Developing a novel combination immunotherapy for triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and has a very poor prognosis due to its tendency to metastasize and relapse. I...
Southwest Transformative Educational Advancement and Mentoring (STEAM) Network
PROJECT SUMMARY The Southwest Transformative Educational Advancement and Mentoring (STEAM) network leverages partnerships at the University of New Mexico (UNM), New Mexico State Un...
Mathematical Oncology Systems Analysis Imaging Center (MOSAIC)
SUMMARY: OVERALL: MATHEMATICAL ONCOLOGY SYSTEMS ANALYSIS IMAGING CENTER Glioblastoma (GBM), the most aggressive primary brain cancer, is amongst the most heterogeneous of cancers,...
MOSAIC: Administrative Core
SUMMARY: ADMINISTRATIVE CORE The overarching objective for the Mayo/Columbia MOSAIC CSBC is to build a conceptual framework to understand tissue state transitions that happen in gl...
MOSAIC: Targeting the Tissue State
SUMMARY: PROJECT 1: TARGETING GLIOMA TISSUE STATES Glioblastoma (GBM) displays extensive cellular heterogeneity which represents a major obstacle for effective treatment. This cell...
MOSAIC: Imaging Human Tissue State Dynamics In Vivo
SUMMARY: PROJECT 2: IMAGING THE DYNAMIC TISSUE STATE IN PATIENTS IN VIVO With a dismal median survival of 16 months, glioblastoma (GBM) is the most common malignant primary brain t...