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20,252 grants found
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Using mHealth to investigate intersectionality and health behaviors: Implications for conceptual models and cancer prevention interventions for marginalized populations
PROJECT SUMMARY/ABSTRACT Tobacco is the leading cause of preventable death and disease and is linked to approximately 20 cancers. The rate of decline of tobacco use has been lower...
Systems Biology of Tumor-Immune-Stromal Interactions in Metastatic Progression
ABSTRACT/SUMMARY – Overall Distant metastasis is the primary cause of cancer-related death. To colonize distant tissues, cancer cells must migrate while evading elimination by the...
Research Capacity Building Core
Project Summary/Abstract - Capacity Building Core Capacity-building efforts in LMICs are critical to advancing the science of implementation and to have global impact on cancer ine...
Research Project 2
Cervical cancer is the leading cause of cancer-related deaths among women in low and middle-income countries (LMICs) and a key contributor to global disparities in cancer incidence...
Developmental Research Program
SUMMARY The University of Hawai`i Cancer Center (UHCC) is the only National Cancer Institute-designated cancer center in Hawai`i and the Pacific. The Center's mission is to re...
Geles: A Novel Imaging Informatics System for Generalizable Lesion Identification in Neuroendocrine Tumors
PROJECT SUMMARY Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are difficult to detect tumors which commonly present at advanced stages, with the liver as the most common...
Career Enhancement Program
SUMMARY The University of Hawai`i Cancer Center (UHCC) SPORE Career Enhancement Program (CEP) will identify and mentor investigators who show promise for independent research caree...
Addressing Underperformance in Clinical Trial Enrollments: Development of a Clinical Trial Toolkit and Expansion of the Clinical Research Footprint
Project Summary Both the impacts from COVID-19 as well as the increasing complexities of clinical trials, with a particular emphasis on precision medicine trials, have led to a rec...
Function and regulation of cytoplasmic p53
ABSTRACT While the principal function of tumor suppressor p53 is a nuclear transcription regulator that transcribes a diverse set of genes involved in apoptosis, cell cycle regulat...
Hawaii Minority Health and Cancer Disparities SPORE
Project Summary/Abstract At the root of health disparities is the diversity that exists in the biological, behavioral, sociocultural, and environmental characteristics of individua...
Administrative Core
Abstract The purpose of the Administrative Core is to provide the leadership and administrative management for the proposed multidisciplinary P50 SPORE aimed at capitalizing on the...
Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...
Project 2: Mitigating Lung Cancer Disparities in Native Hawaiians: A Population-Based Approach to Evaluate Prevention Barriers and Lung Tumor Biology
ABSTRACT We have shown in the Multiethnic Cohort (MEC) that Native Hawaiians have a markedly higher risk of lung cancer and a poorer survival from the disease compared to (non-Hisp...
Systematic Characterization and Targeting of Neomorphic Drivers in Cancer
PROJECT SUMMARY/ABSTRACT More than 3 million somatic mutations and fusion genes have been identified in cancer. However, our ability to predict functional consequences and the ther...
Irreversible Electroporation (IRE) Combined with CD40 Agonism as In Situ Vaccine Therapy for Pancreatic Cancer
Up to 40% of patients with pancreatic cancer present with locally advanced pancreas cancer (LAPC), defined as localized (non-metastatic) but unresectable. Treatment of this patient...
Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric Cancer
ABSTRACTIn the United States, cancer remains the leading cause of death by disease in those 90,000 individuals; and 3) the GOBACK Registry Linkage Birth Cohort, which includes popu...
Lipid storage and catabolism as drivers of metastatic invasion
Metastasis is the primary cause of cancer death, yet therapeutic strategies to inhibit metastatic invasion do not exist. The long-term goal of our research program is to define the...
Targeting EGFL6 in Ovarian Cancer
Project 3 SUMMARY/ABSTRACT High-grade serous ovarian cancer (HGSC) is the most common and aggressive type of epithelial ovarian cancer, and the mortality rates remain unacceptably...
Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric Cancer
ABSTRACTIn the United States, cancer remains the leading cause of death by disease in those 90,000 individuals; and 3) the GOBACK Registry Linkage Birth Cohort, which includes popu...
VPS72 controls Treg cell stability and adaptation to tumor microenvironment
Abstract It became well known that the immune suppressive niche inside the tumor microenvironment (TME) accounts for tumor immune escape and progression, in which the regulatory T...