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20,252 grants found
Showing 2,601 – 2,620 of 20,252 grants
Educational Pathways for Cancer Research (EPCR)
The aim of Educational Pathways for Cancer Research (EPCR) at the Indiana University Simon Comprehensive Cancer Center (IUSCCC) and the Indiana University Bloomington (IUB) School...
Research Project 1: Diffuse Midline Glioma
Project Summary Conventional wisdom holds that radiation therapy is a physically targeted anti-cancer modality and that its cancer targets are genetically and biologically uniform....
Implementing the NYU Electronic Patient Visit Assessment (ePVA) for Head and Neck Cancer In Rural and Urban Populations
ABSTRACT Approximately 66,000 individuals will be diagnosed with head and neck cancer (HNC) in the United States (US) in 2022. Most patients with HNC are treated aggressively with...
Alpha-emitter Imaging for Dosimetry and Treatment Planning
Radiopharmaceutical therapy with α-particle emitters (αRPT) is a highly effective cancer therapy modality; it delivers potent alpha-particle radiation to cancer cells and is theref...
Research Project 2: Neuroblastoma
Project Summary Radiopharmaceuticals have shown tremendous clinical promise, resulting in regulatory approvals of several agents. Such targeted radiotherapy exposes tumor cells to...
Microscale Radionuclide S-values for αRPT
Abstract / Summary – Project 2 Radiopharmaceuticals labeled with alpha-particle emitters (RPT) uniquely satisfy various conditions for therapy of cancer in its advanced stages. Al...
Shared Resource Core 1: Molecular Data Science and Advanced Dosimetry
PROJECT SUMMARY The convergence of radiation oncology, cancer genomics, data science, computational modeling, and artificial intelligence presents spectacular opportunities and cha...
Dissecting the role of DNA damage repair deficiency in Ewing sarcoma pathogenesis for improved risk stratification and treatment
PROJECT SUMMARY Ewing sarcoma is the second most common bone and soft tissue cancer impacting children and adolescents worldwide. It is an aggressive malignancy requiring multimoda...
Macro-to-micro (M2µ) Activity Apportionment for αRPT
Recent advances in the targeted delivery of radionuclides and the increased availability of -emitters appropriate for clinical use have led to patient trials of multiple α-emitter...
Shared Resource Core 2: Clinical Artificial Intelligence Core
PROJECT SUMMARY Artificial intelligence (AI) algorithms have the potential to fundamentally change medicine through their ability to recognize complex patterns in medical data. The...
Cross-Training Core (ROBIN-NEST)
PROJECT SUMMARY Education and training in the radiation medicine sciences are frequently compartmentalized along specific well- worn paths with only superficial attention given to...
Process Development and Preclinical Advancement of a Novel Nanoparticle Formulation for Immune Activation
Summary Despite the success of immune checkpoint inhibitors for some types of cancer, the overall response rate remains suboptimal. The majority of solid tumors exclude T-cells (te...
Radiobioeffect Modeling of αRPT
If absorbed dose is to be used in treatment-planning based α-particle emitter radiopharmaceutical therapy (αRPT), the impact of DNA double-strand break (DSB) repair status- the pro...
Administrative
Project Summary The Administrative Core is responsible for the managerial oversight of the P01. This includes all administrative and budgetary matters, scheduling advisory committe...
Core 1: Animal Models, Pathology and Tissue
Project Summary Alpha-particle -emitter radiopharmaceutical therapy (αRPT) is a new and rapidly evolving therapeutic modality that can deliver highly potent, alpha-particles to dis...
The Empilisweni Center for Women's Health - Advancing Implementation of Equitable Cervical Cancer Control
Abstract (Overall). Cervical cancer is a leading cause of cancer-related deaths among women in low- and middle-income countries (LMICs), and it is almost entirely preventable.1,2-4...
Core 2: Biostatistics
Project Summary The Biostatistics Core (Core C) will collaborate and provide comprehensive statistics service and infrastructure support for clinical and pre-clinical studies to al...
Core 3: Patient Data
Project Summary Overall, the primary effort of this Core will be to conduct a master imaging trial for patients undergoing RPT treatment at Johns Hopkins, as well as to establish d...
Dissecting the Determinants of IDH-mutant Gliomas Response to Mutant IDH Inhibitors
Abstract This proposal focuses on IDH-mutant gliomas, a leading cause of cancer-related death in people under 45-years old. IDH mutations result in profound distortions in metaboli...
Administrative and Engagement Core
Our investigator team at Columbia University and the University of Cape Town, through a nearly thirty-year collaboration under the Khayelitsha Cervical Cancer Screening Program (KC...