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20,252 grants found
Showing 2,581 – 2,600 of 20,252 grants
Pathology Core
Core C: Pathology SUMMARY/ ABSTRACT The individual research projects comprising this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopath...
Developmental Research Program
Developmental Research Program SUMMARY/ABSTRACT The purpose of the Developmental Research Program (DRP) is to fund promising projects by investigators whose current work may not fo...
Career Enhancement Program
Career Enhancement Program SUMMARY/ABSTRACT The central goal of the Career Enhancement Program (CEP) is to use the resources at MD Anderson to train exceptional young investigators...
Immunotherapeutic targeting of gangliosides in Ewing Sarcoma
Project Summary Ewing sarcoma (EWS) is the second most common tumor involving bone in children and young adults and is fatal in most patients with metastatic or relapsed disease. P...
A new mouse model for studying the pathogenesis and immunobiology of intrahepatic cholangiocarcinoma and improving its immunotherapy
ABSTRACT Intrahepatic cholangiocarcinoma (ICC) is an aggressive primary liver cancer (PLC) that is particularly hard to treat, having an overall 5-year survival rate of 8%. Like th...
Population-based assessment of patient-reported outcomes in adults living with metastatic colorectal cancer
With advances in cancer treatment, persons with distant metastatic cancer are now living longer. However, their survivorship needs are not well understood. There has been little re...
Personalizing Post-Polypectomy Surveillance for Colorectal Cancer Prevention
PROJECT SUMMARY AND ABSTRACT Screening is an established method for decreasing colorectal cancer (CRC) incidence and mortality. However, despite guidance supporting CRC screening i...
Radiation Oncology at the Interface of Pediatric Cancer Biology and Data Science
Project Summary Basic scientists and clinical investigators from Dana-Farber/Harvard Cancer Center (DF/HCC) join forces with their counterparts at University of California, San Fra...
Administrative Core
The Harvard/UCSF ROBIN Center will address molecular mechanisms of radiation response and resistance in childhood cancers, using the “quieter” genome of pediatric malignancies to i...
Molecular Characterization Trial
PROJECT SUMMARY The Molecular Characterization Trial (MCT) is the source of biospecimen and data resources for the ROBIN Center. As such, its success is paramount to the success of...
Research Project 1: Diffuse Midline Glioma
Project Summary Conventional wisdom holds that radiation therapy is a physically targeted anti-cancer modality and that its cancer targets are genetically and biologically uniform....
Research Project 2: Neuroblastoma
Project Summary Radiopharmaceuticals have shown tremendous clinical promise, resulting in regulatory approvals of several agents. Such targeted radiotherapy exposes tumor cells to...
Duke PRIME Cancer Research Program
ABSTRACT The U.S. is facing a biomedical workforce crisis, starting with attrition from STEM majors in undergraduate training. The result is a lack of innovative solutions to advan...
Radiation Oncology at the Interface of Pediatric Cancer Biology and Data Science
Project Summary Basic scientists and clinical investigators from Dana-Farber/Harvard Cancer Center (DF/HCC) join forces with their counterparts at University of California, San Fra...
A platform to identify in vivo targets of covalent cancer drugs in 3D tissues
Abstract Covalent inhibitors represent some of the most successful drugs in human history, including aspirin and penicillin. Recently, targeted covalent drugs have taken center sta...
CHOLESTEROL METABOLISM IN THE PHARMACOLOGY OF LIPOSOMAL THERAPEUTICS
ABSTRACT Drug delivery using liposomes increases tumor drug accumulation while sparing normal tissue. Several liposomal chemotherapies are approved to treat cancer. Unfortunately,...
Imaging, Dosimetry and Radiobiology for α-particle Emitter Radiopharmaceutical Therapy
Treatment for almost all patients with metastatic cancer has become a balance between managing often severe, treatment-induced toxicity and preventing cancer progression. Progressi...
Administrative Core
The Harvard/UCSF ROBIN Center will address molecular mechanisms of radiation response and resistance in childhood cancers, using the “quieter” genome of pediatric malignancies to i...
Population-based assessment of patient-reported outcomes in adults living with metastatic colorectal cancer
With advances in cancer treatment, persons with distant metastatic cancer are now living longer. However, their survivorship needs are not well understood. There has been little re...
Molecular Characterization Trial
PROJECT SUMMARY The Molecular Characterization Trial (MCT) is the source of biospecimen and data resources for the ROBIN Center. As such, its success is paramount to the success of...