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20,252 grants found
Showing 2,561 – 2,580 of 20,252 grants
Administrative Core
ABSTRACT/SUMMARY: Administrative Core The Administrative Core of our proposed Stanford Center for Cancer Systems Biology (CCSB) will provide the logistical support for all coordina...
Project 1 Mouse Models Analysis
SUMMARY/ABSTRACT: PROJECT 1 Lymph node (LN) metastasis precedes further dissemination for most solid malignancies and confers a stage III diagnosis. Nonetheless, the mechanistic ro...
Investigating mechanisms of bladder cancer metastasis
The major cause of bladder cancer deaths is due to metastasis, yet to date metastatic bladder cancer (mMIBC) has not been extensively studied and many salient issues remain unresol...
Validation of the Genetically Malleable Oncopig Hepatocellular carcinoma (HCC) Model for Targeted Therapeutic Development
PROJECT ABSTRACT: The goal of this Phase II SBIR proposal is to further validate the genetically defined Oncopig hepatocellular carcinoma (HCC) model—capable of modeling diverse HC...
Targeting tumor microenvironment by nanoimmunodrugs for glioma treatment
Glioblastoma (GBM) is the most lethal form of brain cancer. Treatment options are limited, in part because of inefficient drug delivery across the blood-brain barrier (BBB). GBM mi...
1/2 Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership
PROJECT SUMMARY/ABSTRACT – OVERALL The Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership’s overarching goals are to further increase SDSU’s cancer researc...
Core 1: Animal Models, Pathology and Tissue
Project Summary Alpha-particle -emitter radiopharmaceutical therapy (αRPT) is a new and rapidly evolving therapeutic modality that can deliver highly potent, alpha-particles to dis...
Core 2: Biostatistics
Project Summary The Biostatistics Core (Core C) will collaborate and provide comprehensive statistics service and infrastructure support for clinical and pre-clinical studies to al...
Core 3: Patient Data
Project Summary Overall, the primary effort of this Core will be to conduct a master imaging trial for patients undergoing RPT treatment at Johns Hopkins, as well as to establish d...
The Empilisweni Center for Women's Health - Advancing Implementation of Equitable Cervical Cancer Control
Abstract (Overall). Cervical cancer is a leading cause of cancer-related deaths among women in low- and middle-income countries (LMICs), and it is almost entirely preventable.1,2-4...
Administrative and Engagement Core
Our investigator team at Columbia University and the University of Cape Town, through a nearly thirty-year collaboration under the Khayelitsha Cervical Cancer Screening Program (KC...
Research Capacity Building Core
Project Summary/Abstract - Capacity Building Core Capacity-building efforts in LMICs are critical to advancing the science of implementation and to have global impact on cancer ine...
Research Project 1
Cervical cancer is the leading cause of cancer-related deaths in South Africa where incidence and mortality rates are expected to rise, in part due to the largest global burden of...
Pilot Project 1: Creating Bridges to Reproductive Health Care for Rural Adolescent and Young Adult Cancer Survivors
PROJECT SUMMARY/ ABSTRACT – PILOT PROJECT Reproductive health care in cancer patients is an unmet need in Imperial County, a medically underserved, rural region of the Cancer Resea...
Planning and Evaluation Core
PROJECT SUMMARY/ ABSTRACT – PLANNING AND EVALUATION CORE The Planning and Evaluation (P&E) Core of the Cancer Research and Education to Advance HealTh Equity (CREATE) Partnersh...
Disparities in Clinical Trial Enrollment among Adolescents and Young Adults with Cancer
ABSTRACT More than 70,000 adolescents and young adults (AYAs) are diagnosed with cancer in the United States (US) each year, and fewer than 10% enroll in clinical trials, reflectin...
Targeting EGFL6 in Ovarian Cancer
Project 3 SUMMARY/ABSTRACT High-grade serous ovarian cancer (HGSC) is the most common and aggressive type of epithelial ovarian cancer, and the mortality rates remain unacceptably...
Administrative Core
PROJECT SUMMARY The Administrative Core will provide coordination and oversight across all Center activities. It will help maximize interactions and synergies and will enable optim...
Structure-informed dissection of cancer-specific intracellular and paracrine networks
Understanding cancer cell-autonomous behavior and recruitment of pro-malignant subpopulations to the tumor microenvironment (TME) is critically dependent on the generation of accur...
Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis
Aggressive cancers often lack pharmacologically actionable mutations and do not respond to immune checkpoint blockade, thus deriving only modest clinical benefit from targeted and...