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20,252 grants found
Showing 2,541 – 2,560 of 20,252 grants
Differences in Tumor Biology of Multiple Myeloma in Association with African Ancestry
PROJECT SUMMARY Although multiple myeloma (MM) is the most common blood cancer in Black/African American (AA) individuals, AA patients have been significantly underrepresented in M...
Disparities in Clinical Trial Enrollment among Adolescents and Young Adults with Cancer
ABSTRACT More than 70,000 adolescents and young adults (AYAs) are diagnosed with cancer in the United States (US) each year, and fewer than 10% enroll in clinical trials, reflectin...
Multifactor risk scores with susceptibility gene mutations to enhance risk assessment of pancreatic cancer
PROJECT SUMMARY / ABSTRACT We propose to improve risk assessment of pancreatic ductal adenocarcinoma (PDAC), a major lethal cancer for which no early detection strategy exists. We...
Commercial Readiness for Direct-to-Digital Pathology
Project Summary Applikate Technologies has developed Clearing Histology with Multiphoton Microscopy (CHiMP), a novel tissue processing and imaging platform that provides direct-to-...
Base-Editing the Cancer Kinome to Enable Drug Discovery
The human genome contains 556 kinase genes, commonly called the kinome.Kinases are enzymes that regulate nearly all aspects of cell signaling and their dysregulation leads to exces...
Simulating Ancestrally Unbiased Tumor Evolution To Interrogate Drug Resistance
PROJECT SUMMARY Among cancer patients of distinct ancestries, there are molecular differences in the composition of their tumors, and their responses to therapies. These molecular...
Using microfluidics to realize patient-specific anti-cancer immunotherapies
Project Summary T cells play a central role in the immune response, detecting antigenic peptides cradled within MHC molecules (pMHCs) displayed on the surface of diseased cells via...
Duke PRIME Cancer Research Program
ABSTRACT The U.S. is facing a biomedical workforce crisis, starting with attrition from STEM majors in undergraduate training. The result is a lack of innovative solutions to advan...
The University of Texas MD Anderson Cancer Center SPORE in Ovarian Cancer
The overall goal of the MD Anderson Cancer Center SPORE in Ovarian Cancer is to test and translate novel therapeutic strategies, including those to overcome adaptive resistance to...
Administrative Core
Core A: Administrative Core SUMMARY/ ABSTRACT The overall goal of the MD Anderson Cancer Center SPORE in Ovarian Cancer is to translate high-quality research into improved clinical...
The SIK2 Inhibitor GRN-300 Enhances PARP Inhibitor Sensitivity and Cytotoxic T-Cell Function in Ovarian Cancer
Ovarian cancer is a significant cause of morbidity and mortality that affects nearly 300,000 women worldwide each year. Its poor outcomes relate to delayed diagnosis and developmen...
Next-Generation Engineered NK Cell Immunotherapy for Ovarian Cancer
Project 2 SUMMARY/ ABSTRACT Ovarian cancer is the second most common gynecologic malignancy and remains the leading cause of gynecologic cancer deaths in the US. Therefore, there i...
Targeting EGFL6 in Ovarian Cancer
Project 3 SUMMARY/ABSTRACT High-grade serous ovarian cancer (HGSC) is the most common and aggressive type of epithelial ovarian cancer, and the mortality rates remain unacceptably...
Development of New Technologies at Roswell Park to Further Cancer-Based Research and Treatment Through Genome Modification
Abstract The current application seeks salary support for Aimee Stablewski, PhD who serves as the Director of the Gene Targeting and Transgenic Shared Resource (GeTT) of Roswell Pa...
Novel Biomarkers Predicting Blood Clots in Ovarian Cancer
Project Summary/Abstract Venous thromboembolism (VTE) develops in about one-fourth of patients with ovarian cancer and is associated with significant morbidity and mortality. Chemo...
Dissecting the Determinants of IDH-mutant Gliomas Response to Mutant IDH Inhibitors
Abstract This proposal focuses on IDH-mutant gliomas, a leading cause of cancer-related death in people under 45-years old. IDH mutations result in profound distortions in metaboli...
Shared Resource Core 2: Clinical Artificial Intelligence Core
PROJECT SUMMARY Artificial intelligence (AI) algorithms have the potential to fundamentally change medicine through their ability to recognize complex patterns in medical data. The...
Cross-Training Core (ROBIN-NEST)
PROJECT SUMMARY Education and training in the radiation medicine sciences are frequently compartmentalized along specific well- worn paths with only superficial attention given to...
Development of an immunomodulating peptide as a therapy for osteosarcoma in canine and human
Osteosarcoma (OSA) is the most common primary malignancy of bone in children and adolescents, accounting for approximately 5% of all childhood tumors (www.cancer.gov). Osteosarcoma...
Longitudinal assessment of benefits and harms of cannabis use among community-based cancer patients during initial cancer treatment
Despite federal prohibition on the sale or prescribing of cannabis and cannabinoids (CAC), their medical use has been legalized in 37 states. Although there is limited evidence of...