Browse All Grants
20,252 grants found
Showing 2,521 – 2,540 of 20,252 grants
Role of lipid metabolism in CD8+ T cell ferroptosis
PROJECT SUMMARY Recently, we made a novel and exciting discovery that tumors or the tumor microenvironment (TME) cause T- cell dysfunction and death by inducing ferroptosis in T ce...
Targeting Pediatric Cancer Vulnerabilities
Project Summary / Abstract Despite progress in understanding the molecular basis of childhood malignancies, cancer remains the leading cause of disease-related death in school age...
The role of the cohesin complex in hematopoietic transformation and leukemia maintenance
PROJECT SUMMARY In this proposal, we will define the effects of epigenetic dysregulation via Stag2 loss on three-dimensional chromatin structure and gene expression. We will define...
US-Nigerian Cancer Control Center for Research on Implementation Science and Equity (C3-RISE)
ABSTRACT Nigeria has a substantial number of preventable cancer deaths each year. The human papillomavirus (HPV) vaccine and hepatitis B (HBV) vaccine are both evidence-based strat...
Administrative and Engagement Core
Nigeria is at a crossroads in its cancer control response. On the one hand, the country remains an epicenter of a growing cancer crisis. On the other hand, there are existing guide...
Research and Capacity Building Core
Nigeria, Africa’s most populous country, bears the second highest burden of cancer cases (11%) and deaths (12%) in Africa.1 Evidence-based cancer control interventions such as vacc...
Research Project 1
1 Nigerians make up a significant proportion of individuals in Africa dying from human papillomavirus-(HPV) 2 associated cancers. However, they do not access essential cancer preve...
Novel Biomarkers Predicting Blood Clots in Ovarian Cancer
Project Summary/Abstract Venous thromboembolism (VTE) develops in about one-fourth of patients with ovarian cancer and is associated with significant morbidity and mortality. Chemo...
Research Project 2
Every hour, over 150 people die of hepatitis-related liver diseases in African countries like Nigeria, including hepatocellular carcinoma (HCC) and other liver cancers. Much of thi...
The Impact of Biologic Aging on Immunity-Related Cervical Cancer Outcome Disparities Among Women Living with HIV in Zambia
Project Summary/Abstract Cervical cancer disproportionately affects women of color from low-socioeconomic geographical locations. Locations, such as sub-Saharan Africa, can also ha...
Spatial functional genomics to identify regulators of the tumor microenvironment and cancer immunity
PROJECT SUMMARY Tumor growth and response to therapy, particularly immunotherapy, are all highly dependent on the tumor microenvironment (TME): the collection of cells and extracel...
Liquid biopsy and radiomics for liver cancer surveillance
ABSTRACT Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer death in the United States. While prevention efforts are paramount, most patients succumb to advanced...
The SIK2 Inhibitor GRN-300 enhances PARP Inhibitor sensitivity and overcomes resistance by blocking homologous recombination (HR) DNA repair in ovarian cancer
Project Summary/Abstract - UTMDACC Ovarian SPORE Project 1 Ovarian cancer is a significant cause of morbidity and mortality that affects nearly 300,000 women worldwide each year (1...
Survivorship and cost of care of cervical cancer patients in Puerto Rico in association with cervical cancer screening
PROJECT SUMMARY - PARENT GRANT STUDY Cervical cancer incidence is increasing dramatically (2.4% per year) in Puerto Rico (PR), with increased occurrence of regional (1.5% per year)...
Assessing and Enhancing Survivorship Care In Rural and Urban Patients with Head and Neck Cancer
ABSTRACT Thisapplication is being submitted in response to the Notice of Special Interest (NOSI) identified as "NOT-CA- 24-041." This proposed descriptive research aims t...
Targeting uterine serous carcinoma with antibody-drug conjugates
PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-044.” In recent years, antibody-drug con...
Text Mining and Large Language Models for AI-Driven Evidence-Based Functional Annotation of Clinical Variants
Project Summary Biomedical knowledgebases are faced with the challenge of sustaining high-quality curation in the face of ever increasing amounts of biomedical data and limited cur...
Assessment of hyperthermia-based multimodal approach for hepatic colorectal metastases
ABSTRACT Worldwide, colorectal cancer is responsible for approximately 0.4 million deaths annually, which represent approximately 10% of all cancer deaths. The main cause of death...
Creation of a knowledgebase of high quality assertions of the clinical actionability of somatic variants in cancer
Project Summary Interpretation of the clinical significance of somatic variants in cancer remains a major challenge in cancer diagnosis, prognosis and treatment prediction. The Cli...
Assessing healthy breast tissue for evidence of ancestry-dependent molecular contributions to TNBC disparities
In some diseases, people of a given sex or ancestry experience a higher incidence, more aggressive biology, and different survival. The differences frequently persist after account...