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20,252 grants found
Showing 2,501 – 2,520 of 20,252 grants
Longitudinal assessment of benefits and harms of cannabis use among community-based cancer patients during initial cancer treatment
Despite federal prohibition on the sale or prescribing of cannabis and cannabinoids (CAC), their medical use has been legalized in 37 states. Although there is limited evidence of...
Germline Genetics and Risk of Prostate Cancer in Diverse Populations from the All of Us Program
PROJECT SUMMARY Prostate cancer is the second most common cancer and the second leading cause of cancer death in US men, with African American men having the highest incidence and...
The effectiveness, cost-effectiveness, and budget impact of interventions to improve the delivery of cervical cancer screening in Puerto Rico.
PROJECT SUMMARY Cervical cancer incidence is increasing dramatically (2.5% per year) in Puerto Rico (PR), with increased occurrence of regional (1.7% per year) and distant (4.7% pe...
Evaluating prostate cancer phenotype and genotype classification from circulating tumor DNA as biomarkers for predicting treatment outcomes
PROJECT SUMMARY/ABSTRACT Prostate cancer is the second most common cause of cancer mortality among men. The majority of these deaths are due to resistance to androgen deprivation t...
Targeting metastatic tumors with engineered cellular therapies
SUMMARY Metastatic brain tumors are the most commonly observed intracranial tumors. Patients with advanced breast cancer have a high propensity to metastasize to the brain with hum...
Precision Risk Stratification and Screening for HCC among Patients with Indeterminate Liver Nodules
PROJECT SUMMARY Large gaps in current strategies for risk stratification and surveillance contribute to frequent late-stage detection and poor outcomes in patients with hepatocellu...
Molecular mechanisms driving therapy-induced lineage plasticity
SUMMARY This proposal seeks Dr. Juan Francisco Linares’s salary as a Research Specialist to support Dr. Maria T. Diaz-Meco’s research program at the Weill Cornell Medicine Departme...
Systematic Characterization and Targeting of Neomorphic Drivers in Cancer
PROJECT SUMMARY/ABSTRACT More than 3 million somatic mutations and fusion genes have been identified in cancer. However, our ability to predict functional consequences and the ther...
HORMAD-specific TGF-beta resistant memory T cells for treatment of patients with Gastro-esophageal Cancer
Project Summary This proposal addresses three major challenges in adoptive cellular therapy: 1) T cell persistence; 2) Tumor immune resistance and 3) Target epitope identification...
Irreversible Electroporation (IRE) Combined with CD40 Agonism as In Situ Vaccine Therapy for Pancreatic Cancer
Up to 40% of patients with pancreatic cancer present with locally advanced pancreas cancer (LAPC), defined as localized (non-metastatic) but unresectable. Treatment of this patient...
Personalizing Post-Polypectomy Surveillance for Colorectal Cancer Prevention
PROJECT SUMMARY AND ABSTRACT Screening is an established method for decreasing colorectal cancer (CRC) incidence and mortality. However, despite guidance supporting CRC screening i...
Clinical breast cancer risk prediction models for women with a high-risk benign breast diagnosis
PROJECT SUMMARY/ABSTRACT Over 1.7 million core needle breast biopsies are performed in the U.S. every year among women with either a palpable mass or a suspicious finding on breast...
Development of New Technologies at Roswell Park to Further Cancer-Based Research and Treatment Through Genome Modification
Abstract The current application seeks salary support for Aimee Stablewski, PhD who serves as the Director of the Gene Targeting and Transgenic Shared Resource (GeTT) of Roswell Pa...
Genetically engineered mouse model to improve therapy of NUT carcinoma
NUT carcinoma (NC) is an aggressive squamous carcinoma driven by the BRD4-NUT fusion oncoprotein. NC affects all ages and is highly lethal (>90%), a median survival of 6.5 month...
Metabolic targeting of heterogenous myelodysplastic syndrome stem cells
PROJECT SUMMARY/ABSTRACT The goal of this project is to define vulnerabilities that can be leveraged to comprehensively eradicate MDS stem cells (MDS-SCs). This objective is based...
A democratized platform for mapping the spatial epigenome in tissue
PROJECT SUMMARY AtlasXomics Inc. is commercializing the next generation of spatial biology tools to help researchers understand the epigenetic mechanisms of disease. The goal of th...
Label-Free Optical Redox Imaging for Pretreatment Prognosis of Early-Stage Triple Negative Breast Cancer
Label-Free Optical Redox Imaging for Pretreatment Prognosis of Early-Stage Triple Negative Breast Cancer Abstract Triple negative breast cancer (TNBC) has significant intratumor va...
Using the IL-1R1 and its ligands to optimize the T cell immune response to cancer
IL-1α and β were discovered more than 50-years ago, and knowledge about these pleiotropic cytokines has grown exponentially since that time. Therapeutic use of these molecules has...
Expanding early cancer detection with high throughput OCEANA - Ovarian Cancer Exosome Analysis with Nanoplasmonic Array
Ovarian cancer (OvCa) remains the most lethal gynecologic cancer in the United States. Early detection through screening, particularly of high-risk populations, is an appealing str...
Development of an immunomodulating peptide as a therapy for osteosarcoma in canine and human
Osteosarcoma (OSA) is the most common primary malignancy of bone in children and adolescents, accounting for approximately 5% of all childhood tumors (www.cancer.gov). Osteosarcoma...