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20,252 grants found
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An IGF-1R-targeting peptide drug conjugate for targeted treatment of atypical teratoid/rhabdoid tumors
PROJECT SUMMARY Atypical teratoid/rhabdoid tumors (AT/RT) are rare embryonal central nervous system malignancies that occur in early childhood and are lethal. Current treatment str...
Administrative Core
PROJECT SUMMARY The Administrative Core will provide coordination and oversight across all Center activities. It will help maximize interactions and synergies and will enable optim...
Structure-informed dissection of cancer-specific intracellular and paracrine networks
Understanding cancer cell-autonomous behavior and recruitment of pro-malignant subpopulations to the tumor microenvironment (TME) is critically dependent on the generation of accur...
Administrative Core
PROJECT SUMMARY/ ABSTRACT – ADMINISTRATIVE CORE The goal of the Administrative Core of the Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership is to provide...
Project 1: Defining Mechanisms of MICAL-dependent Pancreatic Cancer Cell Migration
PROJECT SUMMARY/ ABSTRACT – PROJECT 1 Pancreatic duct adenocarcinoma (PDAC) takes the life of an American approximately every 12 minutes and disproportionately affects African Amer...
Project 2: The Intersection of Telehealth and Health Disparities in At-Risk Older Patients with Cancer
PROJECT SUMMARY/ ABSTRACT – PROJECT 2 Telehealth utilization increased rapidly across the US healthcare system in response to the COVID-19 pandemic. As we emerge from the pandemic,...
Pilot Project 1: Creating Bridges to Reproductive Health Care for Rural Adolescent and Young Adult Cancer Survivors
PROJECT SUMMARY/ ABSTRACT – PILOT PROJECT Reproductive health care in cancer patients is an unmet need in Imperial County, a medically underserved, rural region of the Cancer Resea...
Planning and Evaluation Core
PROJECT SUMMARY/ ABSTRACT – PLANNING AND EVALUATION CORE The Planning and Evaluation (P&E) Core of the Cancer Research and Education to Advance HealTh Equity (CREATE) Partnersh...
Research Education Core
PROJECT SUMMARY/ABSTRACT – RESEARCH EDUCATION CORE The goal of the Cancer Research and Education to Advance HealTh Equity (CREATE) Research Education (RE) Core is to provide critic...
Systems Biology of Tumor-Immune-Stromal Interactions in Metastatic Progression
ABSTRACT/SUMMARY – Overall Distant metastasis is the primary cause of cancer-related death. To colonize distant tissues, cancer cells must migrate while evading elimination by the...
Outreach Core
PROJECT SUMMARY/ ABSTRACT – OUTREACH CORE The Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership’s geographic area is composed of San Diego and Imperial Co...
Project 1 Mouse Models Analysis
SUMMARY/ABSTRACT: PROJECT 1 Lymph node (LN) metastasis precedes further dissemination for most solid malignancies and confers a stage III diagnosis. Nonetheless, the mechanistic ro...
Project 2 Human Tumor Analysis
SUMMARY/ABSTRACT: PROJECT 2 Metastasis is the primary cause of cancer-related death. Our recent evidence establishes a new paradigm, “lymph node tolerization,” in which the lymph n...
Outreach Core
ABSTRACT – Outreach Core The Stanford CCSB is committed to advancing and promoting systems biology approaches to cancer research. The Outreach Core will coordinate scientific outre...
KEMRI-PHRD UG1 CASCADE NETWORK UNIT: CERVICAL CANCER PREVENTION FOR WOMEN LIVING WITH HIV RESEARCH
KEMRI-PHRD CLINICAL TRIAL SITE FOR CASCADE NETWORK ‘CERVICAL CANCER PREVENTION FOR WOMEN LIVING WITH HIV Project Summary/Abstract: Cervical cancer is the leading cause of cancer-re...
Multi-cancer early detection using cell-free DNA methylome analysis
PROJECT SUMMARY Detecting cancer early is the best way to fight against cancer. The development of the Multi-Cancer Early Detection (MCED) liquid biopsy tests holds great promise f...
Genetically engineered mouse model to improve therapy of NUT carcinoma
NUT carcinoma (NC) is an aggressive squamous carcinoma driven by the BRD4-NUT fusion oncoprotein. NC affects all ages and is highly lethal (>90%), a median survival of 6.5 month...
Targeting metastatic tumors with engineered cellular therapies
SUMMARY Metastatic brain tumors are the most commonly observed intracranial tumors. Patients with advanced breast cancer have a high propensity to metastasize to the brain with hum...
The role of the cohesin complex in hematopoietic transformation and leukemia maintenance
PROJECT SUMMARY In this proposal, we will define the effects of epigenetic dysregulation via Stag2 loss on three-dimensional chromatin structure and gene expression. We will define...
Metabolic targeting of heterogenous myelodysplastic syndrome stem cells
PROJECT SUMMARY/ABSTRACT The goal of this project is to define vulnerabilities that can be leveraged to comprehensively eradicate MDS stem cells (MDS-SCs). This objective is based...