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20,252 grants found
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Identifying and exploiting therapeutic vulnerabilities of tumor-host interactions that drive bone-to-meninges breast cancer metastasis
Leptomeningeal (LM) metastases occur in a wide variety of hematologic and solid malignancies, including leukemia, breast cancer (BC), and lung cancer. When LM metastases arise, the...
The Alara Imaging Gateway: Linking Electronic Health Records and Radiology Imaging Exams to Report on National Quality Measures to Reduce Cancer Risk from Computed Tomography (Alara Imaging Gateway)
Abstract Alara Imaging, Inc. (Alara) is seeking funding to support the development of robust, IP-protected, HIPAA- compliant commercial quality software to calculate and report on...
Project 3: Inter-Relationships and Prognostic Significance of Breast Cancer Radiomic Risk Features, Tissue Microenvironment, and Adiposity
SUMMARY / ABSTRACT The risk of breast cancer among U.S. women dramatically differs across racial and ethnic populations. Nonetheless, Asian American and Native Hawaiian/Pacific Isl...
Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...
Core 1: Biostatistics & Bioinformatics Core
SUMMARY / ABSTRACT The goal of the Biostatistics and Bioinformatics Core (BBC) is to provide support to the SPORE projects, other cores, as well as the researchers funded through t...
The effectiveness, cost-effectiveness, and budget impact of interventions to improve the delivery of cervical cancer screening in Puerto Rico.
PROJECT SUMMARY Cervical cancer incidence is increasing dramatically (2.5% per year) in Puerto Rico (PR), with increased occurrence of regional (1.7% per year) and distant (4.7% pe...
Core 2: Outreach & Recruitment Core
SUMMARY / ABSTRACT The Outreach and Recruitment Core (ORC) of this P50 application will play an integral role in the proposed research to achieve the overarching goal of maximizing...
Core 3: Pathology & Biospecimens Core
SUMMARY /ABSTRACT Access to relevant biospecimens is critical to translational research on minority populations. The lack of research specimens from racial and ethnic minority popu...
Developmental Research Program
SUMMARY The University of Hawai`i Cancer Center (UHCC) is the only National Cancer Institute-designated cancer center in Hawai`i and the Pacific. The Center's mission is to re...
Career Enhancement Program
SUMMARY The University of Hawai`i Cancer Center (UHCC) SPORE Career Enhancement Program (CEP) will identify and mentor investigators who show promise for independent research caree...
Next-Generation Engineered NK Cell Immunotherapy for Ovarian Cancer
Project 2 SUMMARY/ ABSTRACT Ovarian cancer is the second most common gynecologic malignancy and remains the leading cause of gynecologic cancer deaths in the US. Therefore, there i...
Using microfluidics to realize patient-specific anti-cancer immunotherapies
Project Summary T cells play a central role in the immune response, detecting antigenic peptides cradled within MHC molecules (pMHCs) displayed on the surface of diseased cells via...
Sensitization to RIPK1-dependent death as a strategy to enhance response of renal cell carcinoma (RCC) to immunotherapy
Abstract The use of anti-CTLA, anti-PD1 and anti-PD-L1, collectively known as immune checkpoint blockade (ICB), has revolutionized the treatment of cancer. The effectiveness of ICB...
Targeting p300 to Overcome PARP inhibitor resistance induced by acidic tumor microenvironment
Project 4 PROJECT SUMMARY/ABSTRACT The overall goal of this proposal is to develop a novel strategy to improve efficacy and/or overcome resistance to PARP inhibitors induced by aci...
Unbiased electrothermal flow-enhanced identification of antigen-specific T cells in lung cancer
Project Abstract/Summary Despite their success, immunotherapies fail to engage T cells on an antigen-dependent basis rather opting to reactivate a broad spectrum of T cells of unkn...
Cancer Emulation Analysis with Deep Neural Network
Project Summary To objectively quantify the relative effectiveness of drugs, devices, and treatment procedures on cancer prognosis, rigorously designed and executed randomized clin...
Developing an inhibitor of EIF2AK1 to overcome ineffective erythropoiesis in myelodysplastic syndromes with ringed sideroblasts
ABSTRACT Mutations in the splicing factor SF3B1 (SF3B1MT), which occur in 20% of patients with myelodysplastic syndromes (MDS), are the hallmarks of MDS-RS, an MDS subtype characte...
Hyperpolarized 13C Metabolic Imaging of Tumorigenesis in the Liver
Project Summary. Aberrant glycolysis and mitochondrial function are features of most liver diseases including hepatocellular carcinoma (HCC). Despite these metabolic signatures, th...
SaefCAR: Regulatable CAR-T cells for safe and effective immunotherapy
Project Summary: Despite the remarkable success in the treatment of some hematological cancers, the risk of serious adverse events and loss of potency remain major problems that th...
Development of an Anti-Cancer Approach Through a Novel Pathway of Translational Regulation
ABSTRACT STAT3 (Signal Transducer and Activator of Transcription 3) is a transcriptional regulator that plays crucial role in malignant transformation of the cells, tumor growth an...