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20,252 grants found
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Administrative and Engagement Core
Nigeria is at a crossroads in its cancer control response. On the one hand, the country remains an epicenter of a growing cancer crisis. On the other hand, there are existing guide...
Research and Capacity Building Core
Nigeria, Africa’s most populous country, bears the second highest burden of cancer cases (11%) and deaths (12%) in Africa.1 Evidence-based cancer control interventions such as vacc...
Research Project 1
1 Nigerians make up a significant proportion of individuals in Africa dying from human papillomavirus-(HPV) 2 associated cancers. However, they do not access essential cancer preve...
Research Project 2
Every hour, over 150 people die of hepatitis-related liver diseases in African countries like Nigeria, including hepatocellular carcinoma (HCC) and other liver cancers. Much of thi...
Research Education Core
PROJECT SUMMARY/ABSTRACT – RESEARCH EDUCATION CORE The goal of the Cancer Research and Education to Advance HealTh Equity (CREATE) Research Education (RE) Core is to provide critic...
7HP349, an Integrin Activator to Treat Patients With anti-PD-1 Resistant Solid Tumors
PROJECT SUMMARY/ABSTRACT Immuno-oncology (IO) therapies, particularly immune checkpoint inhibitors (ICIs) such as nivolumab (anti-PD- 1) and ipilimumab (anti-CTLA-4) have made rapi...
Outreach Core
PROJECT SUMMARY/ ABSTRACT – OUTREACH CORE The Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership’s geographic area is composed of San Diego and Imperial Co...
The Impact of Metastatic Site On Dendritic Cell-Driven Tumor Immunity
Project Summary/Abstract The prognosis for pancreatic ductal adenocarcinomas (PDAC) patients is dismal. Unfortunately, attempts at immunotherapy for PDAC to date using single agent...
Center for Cancer Systems Therapeutics (CaST)
PROJECT SUMMARY Patients with aggressive cancers often present with no pharmacologically actionable mutations and poor or no sensitivity to immune checkpoint blockade, thus derivin...
Ferroptosis in drug resistant glioma
Project Abstract Cancer drug resistance is the last frontier in extending patient overall survival, especially in the deadly brain tumor – glioblastoma (GBM). GBM currently has one...
Molecular Mechanisms by which Statins Prevent and Reverse Hepatocellular Carcinoma
Project Summary/Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. HMG-CoA reductase (HMGCR) inhibitors, statins, show high potential...
VPS72 controls Treg cell stability and adaptation to tumor microenvironment
Abstract It became well known that the immune suppressive niche inside the tumor microenvironment (TME) accounts for tumor immune escape and progression, in which the regulatory T...
KEMRI-PHRD UG1 CASCADE NETWORK UNIT: CERVICAL CANCER PREVENTION FOR WOMEN LIVING WITH HIV RESEARCH
KEMRI-PHRD CLINICAL TRIAL SITE FOR CASCADE NETWORK ‘CERVICAL CANCER PREVENTION FOR WOMEN LIVING WITH HIV Project Summary/Abstract: Cervical cancer is the leading cause of cancer-re...
Development of contrast agents to facilitate image-guided surgery
Presently, surgical resection offers the only chance of cure for patients with pancreatic adenocarcinoma. While the goal of resection is to obtain R0 (negative) margins, the report...
Multi-cancer early detection using cell-free DNA methylome analysis
PROJECT SUMMARY Detecting cancer early is the best way to fight against cancer. The development of the Multi-Cancer Early Detection (MCED) liquid biopsy tests holds great promise f...
Clinical Translation of dual-modality transrectal ultrasound and photoacoustic imaging for detection of aggressive human prostate cancer
ABSTRACT Prostate cancer (PCa), with an annually increasing incident rate, has become the most commonly diagnosed cancer in American men. The accurate diagnosis of aggressive PCa i...
Enhanced BReast and cErvical cAncer screening in Kenya THROUGH implementation science research and training (The BREAKTHROUGH Center)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...
Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...
Germline Genetic Modifiers of Radiation Response
Approximately 50% of cancer patients receiving ionizing radiation suffer from radiation-induced normal tissue injury that significantly affects quality of life and presents potenti...
Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...