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20,252 grants found
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Hawaii Minority Health and Cancer Disparities SPORE
Project Summary/Abstract At the root of health disparities is the diversity that exists in the biological, behavioral, sociocultural, and environmental characteristics of individua...
Administrative Core
Abstract The purpose of the Administrative Core is to provide the leadership and administrative management for the proposed multidisciplinary P50 SPORE aimed at capitalizing on the...
Project 2: Mitigating Lung Cancer Disparities in Native Hawaiians: A Population-Based Approach to Evaluate Prevention Barriers and Lung Tumor Biology
ABSTRACT We have shown in the Multiethnic Cohort (MEC) that Native Hawaiians have a markedly higher risk of lung cancer and a poorer survival from the disease compared to (non-Hisp...
Project 3: Inter-Relationships and Prognostic Significance of Breast Cancer Radiomic Risk Features, Tissue Microenvironment, and Adiposity
SUMMARY / ABSTRACT The risk of breast cancer among U.S. women dramatically differs across racial and ethnic populations. Nonetheless, Asian American and Native Hawaiian/Pacific Isl...
Core 1: Biostatistics & Bioinformatics Core
SUMMARY / ABSTRACT The goal of the Biostatistics and Bioinformatics Core (BBC) is to provide support to the SPORE projects, other cores, as well as the researchers funded through t...
Core 2: Outreach & Recruitment Core
SUMMARY / ABSTRACT The Outreach and Recruitment Core (ORC) of this P50 application will play an integral role in the proposed research to achieve the overarching goal of maximizing...
Core 3: Pathology & Biospecimens Core
SUMMARY /ABSTRACT Access to relevant biospecimens is critical to translational research on minority populations. The lack of research specimens from racial and ethnic minority popu...
Molecular Mechanisms by which Statins Prevent and Reverse Hepatocellular Carcinoma
Project Summary/Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. HMG-CoA reductase (HMGCR) inhibitors, statins, show high potential...
Children's Oncology Group
PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60-years ago, the prognosis of childhood cancer has improved dramatically....
REWIRING CANCER-INDUCED ABNORMALITIES IN THE VASCULAR BARRIER
Summary Tumors are known to induce the formation of unique microenvironments in distant organs that facilitate seeding, survival, and growth of metastatic nodules. These sites, kno...
Creation of a knowledgebase of high quality assertions of the clinical actionability of somatic variants in cancer
Project Summary Interpretation of the clinical significance of somatic variants in cancer remains a major challenge in cancer diagnosis, prognosis and treatment prediction. The Cli...
Assessment of hyperthermia-based multimodal approach for hepatic colorectal metastases
ABSTRACT Worldwide, colorectal cancer is responsible for approximately 0.4 million deaths annually, which represent approximately 10% of all cancer deaths. The main cause of death...
Preventing invasive prostate cancer
Abstract: Cell motility is required for in situ cancer to form invasive primary prostate cancer (PCa). Inhibiting motility would intercept formation of invasive cancer. Until now i...
Enhanced BReast and cErvical cAncer screening in Kenya THROUGH implementation science research and training (The BREAKTHROUGH Center)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...
Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...
Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...
Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...
Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...
The Impact of Metastatic Site On Dendritic Cell-Driven Tumor Immunity
Project Summary/Abstract The prognosis for pancreatic ductal adenocarcinomas (PDAC) patients is dismal. Unfortunately, attempts at immunotherapy for PDAC to date using single agent...
US-Nigerian Cancer Control Center for Research on Implementation Science and Equity (C3-RISE)
ABSTRACT Nigeria has a substantial number of preventable cancer deaths each year. The human papillomavirus (HPV) vaccine and hepatitis B (HBV) vaccine are both evidence-based strat...