Browse All Grants
20,252 grants found
Showing 2,401 – 2,420 of 20,252 grants
A democratized platform for mapping the spatial epigenome in tissue
PROJECT SUMMARY AtlasXomics Inc. is commercializing the next generation of spatial biology tools to help researchers understand the epigenetic mechanisms of disease. The goal of th...
Imaging, Dosimetry and Radiobiology for α-particle Emitter Radiopharmaceutical Therapy
Treatment for almost all patients with metastatic cancer has become a balance between managing often severe, treatment-induced toxicity and preventing cancer progression. Progressi...
Alpha-emitter Imaging for Dosimetry and Treatment Planning
Radiopharmaceutical therapy with α-particle emitters (αRPT) is a highly effective cancer therapy modality; it delivers potent alpha-particle radiation to cancer cells and is theref...
Research Project 1
Cervical cancer is the leading cause of cancer-related deaths in South Africa where incidence and mortality rates are expected to rise, in part due to the largest global burden of...
Research Project 2
Cervical cancer is the leading cause of cancer-related deaths among women in low and middle-income countries (LMICs) and a key contributor to global disparities in cancer incidence...
Microscale Radionuclide S-values for αRPT
Abstract / Summary – Project 2 Radiopharmaceuticals labeled with alpha-particle emitters (RPT) uniquely satisfy various conditions for therapy of cancer in its advanced stages. Al...
Precision Risk Stratification and Screening for HCC among Patients with Indeterminate Liver Nodules
PROJECT SUMMARY Large gaps in current strategies for risk stratification and surveillance contribute to frequent late-stage detection and poor outcomes in patients with hepatocellu...
Macro-to-micro (M2µ) Activity Apportionment for αRPT
Recent advances in the targeted delivery of radionuclides and the increased availability of -emitters appropriate for clinical use have led to patient trials of multiple α-emitter...
Project 2 Human Tumor Analysis
SUMMARY/ABSTRACT: PROJECT 2 Metastasis is the primary cause of cancer-related death. Our recent evidence establishes a new paradigm, “lymph node tolerization,” in which the lymph n...
Outreach Core
ABSTRACT – Outreach Core The Stanford CCSB is committed to advancing and promoting systems biology approaches to cancer research. The Outreach Core will coordinate scientific outre...
Biospecimen and Data Core
ABSTRACT/SUMMARY: BIOSPECIMEN AND DATA CORE Our CCSB will dissect how interactions between malignant, stromal and immune cells in the primary tumor and lymph nodes (LN) influence s...
Targeting Pediatric Cancer Vulnerabilities
Project Summary / Abstract Despite progress in understanding the molecular basis of childhood malignancies, cancer remains the leading cause of disease-related death in school age...
Identifying and exploiting therapeutic vulnerabilities of tumor-host interactions that drive bone-to-meninges breast cancer metastasis
Leptomeningeal (LM) metastases occur in a wide variety of hematologic and solid malignancies, including leukemia, breast cancer (BC), and lung cancer. When LM metastases arise, the...
Administrative
Project Summary The Administrative Core is responsible for the managerial oversight of the P01. This includes all administrative and budgetary matters, scheduling advisory committe...
Dissecting the role of DNA damage repair deficiency in Ewing sarcoma pathogenesis for improved risk stratification and treatment
PROJECT SUMMARY Ewing sarcoma is the second most common bone and soft tissue cancer impacting children and adolescents worldwide. It is an aggressive malignancy requiring multimoda...
Administrative Core
PROJECT SUMMARY/ ABSTRACT – ADMINISTRATIVE CORE The goal of the Administrative Core of the Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership is to provide...
Project 1: Defining Mechanisms of MICAL-dependent Pancreatic Cancer Cell Migration
PROJECT SUMMARY/ ABSTRACT – PROJECT 1 Pancreatic duct adenocarcinoma (PDAC) takes the life of an American approximately every 12 minutes and disproportionately affects African Amer...
Project 2: The Intersection of Telehealth and Health Disparities in At-Risk Older Patients with Cancer
PROJECT SUMMARY/ ABSTRACT – PROJECT 2 Telehealth utilization increased rapidly across the US healthcare system in response to the COVID-19 pandemic. As we emerge from the pandemic,...
Implementing the NYU Electronic Patient Visit Assessment (ePVA) for Head and Neck Cancer In Rural and Urban Populations
ABSTRACT Approximately 66,000 individuals will be diagnosed with head and neck cancer (HNC) in the United States (US) in 2022. Most patients with HNC are treated aggressively with...
CHOLESTEROL METABOLISM IN THE PHARMACOLOGY OF LIPOSOMAL THERAPEUTICS
ABSTRACT Drug delivery using liposomes increases tumor drug accumulation while sparing normal tissue. Several liposomal chemotherapies are approved to treat cancer. Unfortunately,...