Browse All Grants
20,252 grants found
Showing 221 – 240 of 20,252 grants
Integrative Multiomics and Clinical Laboratory Translation for Advanced, Rare, and Pediatric Cancers
ABSTRACT The project aims to incorporate emerging technologies in genomics, transcriptomics, epigenomics and proteomics for the analyses of advanced, rare, and pediatric cancers. T...
Quantitative in vivo dosimetry for radiotherapy using model-based X-ray-induced acoustic computed tomography
Abstract Accurate dose delivery at the tumor site is crucial for the success of radiotherapy (RT) for cancer treatment. However, as yet there are no techniques in clinics with the...
Leveraging Observational (Real World) Data to Advance Precision Oncology
OVERALL ABSTRACT Leveraging Observational (Real World) Data to Advance Precision Oncology Principal Investigator: Charles Sawyers, Memorial Sloan Kettering Cancer Center Precision...
Project 1: Overcoming methodologic barriers to analysis of observational clinico-genomic data in oncology
PROJECT 1 ABSTRACT Overcoming methodologic barriers to analysis of observational clinico-genomic data in oncology Project Leaders: Kenneth Kehl (DFCI); Deborah Schrag (MSK) Precisi...
Project 2: Integrating race, ethnicity, and genomic ancestry across GENIE to understand genetic and environmental contributions to pan-cancer risk, prognosis, and outcomes
PROJECT 2 ABSTRACT Integrating race, ethnicity, and genomic ancestry across GENIE to understand genetic and environmental contributions to pan-cancer risk, prognosis, and outcomes....
Project 3: Predictors of sensitivity to immunotherapy and targeted treatments based on real world evidence
PROJECT 3 ABSTRACT Predictors of sensitivity to immunotherapy and targeted treatments based on real world evidence Project Leaders: Phillipe Bedard (Princess Margaret); Nikolaus Sc...
Administrative Core
CORE C ABSTRACT Administrative Core Core Leader: Charles Sawyers (MSK) The P01 Administrative Core will provide the organizational support and leadership necessary to support the s...
PET Biomarker for synaptic density changes after radiation therapy
Project Summary/Abstract: Whole brain synaptic density imaging with quantitative positron emission tomography (PET) has demonstrated critical insights into understanding of neurode...
Multifunctional EPRI Instrument to Advance Therapies in Biomedical Sciences
Abstract: Electron paramagnetic resonance imaging (EPRI), where electron spins are the subject of the investigation, is a promising tool and has the ability to provide maps of mult...
Leveraging HIV care infrastructure for implementation of context-adapted liver cancer comprehensive control strategies in Uganda: The LC3 Study
Project Summary: For >18-years, Makerere and Johns Hopkins universities have partnered in Uganda to characterize the epidemiology of hepatitis B (HBV) and HIV co-infection, defi...
Engineered Glioblastoma-specific T cells using Immunostimulatory Photothermal Nanoparticles
PROJECT SUMMARY The goal of this STTR Phase I application is to establish the feasibility of commercializing a personalized and multi-targeted adoptive T cell therapy (ATCT) for gl...
Project 3 - Deciphering the Role of the Translational Oncogenic Program in Prostate Cance
PROJECT SUMMARY/ABSTRACT – PROJECT 3 (RUGGERO): DECIPHERING THE ROLE OF THE TRANSLATIONAL ONCOGENIC PROGRAM IN PROSTATE CANCER While the approved treatments for castrate-resistant...
Core 1 - Biostatistics and Bioinformatics Core (BBC)
PROJECT SUMMARY/ABSTRACT – CORE 1 - BIOSTATISTICS AND BIOINFORMATICS CORE (BBC) The goal of the Biostatistics and Bioinformatics Core (BBC) is to collaborate with SPORE Investigato...
Core 2 - Prostate Tissue Core (PTC)
PROJECT SUMMARY - CORE 2 : PROSTATE TISSUE CORE (PTC) The Prostate Tissue Core (PTC) is the organizing structure managing human tissue, biospecimens and pathology resources of the...
Developmental Research Program (DRP)
PROJECT SUMMARY/ABSTRACT – DEVELOPMENTAL RESEARCH PROGRAM – (DRP) The fundamental objective of the Developing Research Program (DRP) proposed in this SPORE application, is to ident...
Career Enhancement Program (CEP)
PROJECT SUMMARY/ABSTRACT – CAREER ENHANCEMENT PROGRAM – (CEP) The goal of the Career Enhancement Program (CEP) is to recruit promising investigators, at any level of their career,...
Biomarker-Driven Strategies to Overcome Immunotherapy Resistance in STK11-Deficient NSCLC
SUMMARY Despite significant advances in Immuno-Oncology (IO) treatments, lung cancers with loss-of-function mutations in STK11, comprising 20-30% of cases, demonstrate poor prognos...
Development of an Innovative PSMA-Targeted Small Molecule Prodrug for Prostate Cancer
ABSTRACT Prostate cancer (PCa) is the most commonly diagnosed cancer and second leading cause of cancer death in American men.1 For metastatic castration resistant prostate cancer...
Development of integrated risk models of genetic and non-genetic risk factors in endometrial cancer across diverse ancestries
PROJECT SUMMARY The incidence of Endometrial Cancer (EC) has been rising, with a notable increase in mortality rates, especially among Black women who face a higher risk of aggress...
UCSF Specialized Programs of Research Excellence (SPOREs) in Prostate Cancer
PROJECT SUMMARY / ABSTRACT – OVERALL Prostate cancer is the second leading cause of cancer deaths of men in the United States and places a significant health burden on society. The...