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20,252 grants found
Showing 2,361 – 2,380 of 20,252 grants
Aerosolized Epigenetic Therapy for Metastatic Lung Cancer
Project Summary Lung cancer (LC) with over 2 million cases/year worldwide also remains the leading cause of cancer- related death in the US and Europe. Treating LC remains challeng...
Validation of the Genetically Malleable Oncopig Hepatocellular carcinoma (HCC) Model for Targeted Therapeutic Development
PROJECT ABSTRACT: The goal of this Phase II SBIR proposal is to further validate the genetically defined Oncopig hepatocellular carcinoma (HCC) model—capable of modeling diverse HC...
ADEPT-STAR therapy for high risk neuroblastoma
PROJECT SUMMARY Cancer remains a primary health concern despite significant advancements in treatment. In the past decade, cell and gene (C&G) therapies along with immuno-oncol...
7HP349, an Integrin Activator to Treat Patients With anti-PD-1 Resistant Solid Tumors
PROJECT SUMMARY/ABSTRACT Immuno-oncology (IO) therapies, particularly immune checkpoint inhibitors (ICIs) such as nivolumab (anti-PD- 1) and ipilimumab (anti-CTLA-4) have made rapi...
1/2 Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership
PROJECT SUMMARY/ABSTRACT – OVERALL The Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership’s overarching goals are to further increase SDSU’s cancer researc...
Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis
Aggressive cancers often lack pharmacologically actionable mutations and do not respond to immune checkpoint blockade, thus deriving only modest clinical benefit from targeted and...
Drug Mechanism of Action-based targeting of tumor subpopulations
Patients with aggressive cancers often present with no pharmacologically actionable mutations and fail to respond to immune checkpoint blockade, thus deriving only modest improveme...
Outreach Core
Project Summary Crucial to the long-lasting impact of the Center for Cancer Systems Therapeutics (CaST) is a robust and inclusive Outreach effort. The community and computational i...
Advanced Single Cell Technology Innovation Core
PROJECT SUMMARY The proposed Cancer Systems Therapeutics (CaST) Center focuses on understanding and targeting molecularly distinct yet co-existing cell states and transitions that...
Administrative Core
ABSTRACT/SUMMARY: Administrative Core The Administrative Core of our proposed Stanford Center for Cancer Systems Biology (CCSB) will provide the logistical support for all coordina...
Expanding early cancer detection with high throughput OCEANA - Ovarian Cancer Exosome Analysis with Nanoplasmonic Array
Ovarian cancer (OvCa) remains the most lethal gynecologic cancer in the United States. Early detection through screening, particularly of high-risk populations, is an appealing str...
The role of the cohesin complex in hematopoietic transformation and leukemia maintenance
PROJECT SUMMARY In this proposal, we will define the effects of epigenetic dysregulation via Stag2 loss on three-dimensional chromatin structure and transcriptional regulation. We...
Integrating cervical cancer screening within the outpatient emergency departments in Kenya
Integrating cervical cancer screening within the outpatient emergency departments in Kenya This application is in response to Notice of Special Interest (NOSI): Administrative Supp...
Policy implementation for cancer control in Nigeria
Project Summary This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-039. Policy is a powerful tool for achieving cance...
Advanced Single Cell Technology Innovation Core
PROJECT SUMMARY The proposed Cancer Systems Therapeutics (CaST) Center focuses on understanding and targeting molecularly distinct yet co-existing cell states and transitions that...
Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable...
Research and Capacity Building Core
Nigeria, Africa’s most populous country, bears the second highest burden of cancer cases (11%) and deaths (12%) in Africa.1 Evidence-based cancer control interventions such as vacc...
Drug Mechanism of Action-based targeting of tumor subpopulations
The primary site of prostate cancer metastasis is bone, which is associated with significant morbidity and mortality; yet there are few curative treatment options, in part due to t...
Shared Resource Core 1: Molecular Data Science and Advanced Dosimetry
PROJECT SUMMARY The convergence of radiation oncology, cancer genomics, data science, computational modeling, and artificial intelligence presents spectacular opportunities and cha...
Preventing invasive prostate cancer
Abstract: Cell motility is required for in situ cancer to form invasive primary prostate cancer (PCa). Inhibiting motility would intercept formation of invasive cancer. Until now i...