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20,252 grants found
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Lipid storage and catabolism as drivers of metastatic invasion
Metastasis is the primary cause of cancer death, yet therapeutic strategies to inhibit metastatic invasion do not exist. The long-term goal of our research program is to define the...
Liquid biopsy and radiomics for liver cancer surveillance
ABSTRACT Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer death in the United States. While prevention efforts are paramount, most patients succumb to advanced...
Radiobioeffect Modeling of αRPT
If absorbed dose is to be used in treatment-planning based α-particle emitter radiopharmaceutical therapy (αRPT), the impact of DNA double-strand break (DSB) repair status- the pro...
Educational Pathways for Cancer Research (EPCR)
The aim of Educational Pathways for Cancer Research (EPCR) at the Indiana University Simon Comprehensive Cancer Center (IUSCCC) and the Indiana University Bloomington (IUB) School...
A platform to identify in vivo targets of covalent cancer drugs in 3D tissues
Abstract Covalent inhibitors represent some of the most successful drugs in human history, including aspirin and penicillin. Recently, targeted covalent drugs have taken center sta...
Immunotherapeutic targeting of gangliosides in Ewing Sarcoma
Project Summary Ewing sarcoma (EWS) is the second most common tumor involving bone in children and young adults and is fatal in most patients with metastatic or relapsed disease. P...
Enhancing Diversity and Addressing Disparities at the 7th Cancer Cachexia Conference
ABSTRACT This proposal requests partial support for the 7th Cancer Cachexia Conference organized by the Cancer Cachexia Society (CCS), to be held from September 28-30, 2023, in Edi...
Antitumor potential of AvFc lectibody in non-small cell lung cancer
PROJECT SUMMARY / ABSTRACT The goal of this project is to develop a novel tumor glycobiomarker-targeting agent against non-small cell lung cancer (NSCLC). NSCLC accounts for the ma...
Targeting tumor microenvironment by nanoimmunodrugs for glioma treatment
Glioblastoma (GBM) is the most lethal form of brain cancer. Treatment options are limited, in part because of inefficient drug delivery across the blood-brain barrier (BBB). GBM mi...
Investigating mechanisms of bladder cancer metastasis
The major cause of bladder cancer deaths is due to metastasis, yet to date metastatic bladder cancer (mMIBC) has not been extensively studied and many salient issues remain unresol...
The University of Texas MD Anderson Cancer Center SPORE in Ovarian Cancer
The overall goal of the MD Anderson Cancer Center SPORE in Ovarian Cancer is to test and translate novel therapeutic strategies, including those to overcome adaptive resistance to...
Administrative Core
Core A: Administrative Core SUMMARY/ ABSTRACT The overall goal of the MD Anderson Cancer Center SPORE in Ovarian Cancer is to translate high-quality research into improved clinical...
Clinical breast cancer risk prediction models for women with a high-risk benign breast diagnosis
PROJECT SUMMARY/ABSTRACT Over 1.7 million core needle breast biopsies are performed in the U.S. every year among women with either a palpable mass or a suspicious finding on breast...
The SIK2 Inhibitor GRN-300 Enhances PARP Inhibitor Sensitivity and Cytotoxic T-Cell Function in Ovarian Cancer
Ovarian cancer is a significant cause of morbidity and mortality that affects nearly 300,000 women worldwide each year. Its poor outcomes relate to delayed diagnosis and developmen...
Spatial functional genomics to identify regulators of the tumor microenvironment and cancer immunity
PROJECT SUMMARY Tumor growth and response to therapy, particularly immunotherapy, are all highly dependent on the tumor microenvironment (TME): the collection of cells and extracel...
Multifactor risk scores with susceptibility gene mutations to enhance risk assessment of pancreatic cancer
PROJECT SUMMARY / ABSTRACT We propose to improve risk assessment of pancreatic ductal adenocarcinoma (PDAC), a major lethal cancer for which no early detection strategy exists. We...
Using mHealth to investigate intersectionality and health behaviors: Implications for conceptual models and cancer prevention interventions for marginalized populations
PROJECT SUMMARY/ABSTRACT Tobacco is the leading cause of preventable death and disease and is linked to approximately 20 cancers. The rate of decline of tobacco use has been lower...
Differences in Tumor Biology of Multiple Myeloma in Association with African Ancestry
PROJECT SUMMARY Although multiple myeloma (MM) is the most common blood cancer in Black/African American (AA) individuals, AA patients have been significantly underrepresented in M...
Targeting Non-Canonical STING Signaling to Treat SPOP Mutant Castration-Resistant Prostate Cancer
PROJECT SUMMARY/ABSTRACT Tumor suppressor gene speckle-type POZ protein (SPOP), a substrate adaptor of cullin3-RING ubiquitin ligase, demonstrates heterozygous missense mutations i...
Center for Cancer Systems Therapeutics (CaST)
PROJECT SUMMARY Patients with aggressive cancers often present with no pharmacologically actionable mutations and poor or no sensitivity to immune checkpoint blockade, thus derivin...