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20,252 grants found
Showing 2,321 – 2,340 of 20,252 grants
Actionable categories of avoidable hospital care among adults with cancer
PROJECT SUMMARY/ABSTRACT Nearly all provider groups in Medicare’s five-year Oncology Care Model alternative payment program expressed a goal to reduce hospital use by cancer patien...
Administrative Core
PROJECT SUMMARY The Administrative Core provides strong, centralized scientific and administrative leadership to the PPG, which facilitates synergistic interactions between the fou...
Precision Interception of Gastric Cancer Precursors Through Molecular and Cellular Risk Stratification
ABSTRACT – OVERALL Gastric cancer is a leading cause of cancer morbidity and mortality worldwide. The bacterium Helicobacter pylori (Hp) is the single greatest risk factor for gast...
Project 1 - Molecular and Cellular Determinants of High Risk Gastric Precancerous Lesions
ABSTRACT – PROJECT 1 The main objective of Project 1 is to deconvolute the molecular features of high-risk gastric cancer precursor lesions. Dr. Hanlee Ji, Project Leader, previous...
Broad Genomic Profiling in patients with advanced lung cancer: empirically assessing adoption, clinical utility, and the value of additional evidence in an evolving landscape of cancer care
Personalized cancer treatment is becoming a reality. The real-world adoption of broad genomic profiling (BGP) has enabled the simultaneous testing of hundreds of potentially target...
Targeting APOBEC3A-induced genetic heterogeneity and drug resistance in bladder cancer
PROJECT SUMMARY/ ABSTRACT Every five minutes, a new patient is diagnosed with urothelial carcinoma (UC) in the United States, resulting in the death of 18,000 patients annually. Ne...
A Prospective Cohort Study of Patients with Non-Small Cell Lung Cancer and Multiple Myeloma to Assess the Benefits and Harms Related to Cannabis Use During Treatment
With the majority of Americans supporting legalization of medical cannabis, the number of patients asking their clinicians about medical cannabis has also significantly increased....
Digital smoking cessation intervention for nationally-recruited American Indians and Alaska Natives: A full-scale randomized controlled trial
PROJECT SUMMARY/ABSTRACT (DESCRIPTION) Since the early 1980s, American Indians and Alaska Natives (AIANs) have maintained the highest rates of commercial cigarette smoking of any r...
Pdcd4-Rictor Interaction in Suppression of Lung Tumorigenesis
Project Summary/Abstract Lung cancer is the leading cause of cancer-related deaths in the United States. The high mortality rate is not only due to the lack of effective early dete...
Functions of mutant IDH in cholangiocarcinoma
PROJECT SUMMARY Isocitrate dehydrogenase 1 is the most frequently mutated metabolic gene across all cancers. Among epithelial malignancies, IDH1 mutations are particularly common i...
Use and Impact of Quantitative Information in Tobacco Risk Communications
Project Summary/Abstract In 2019, nearly 14 of every 100 U.S. adults aged 18-years or older (14.0%) currently smoked cigarettes. Current strategies of tobacco use risk communicatio...
Assessing Benefits and Harms of Medical Cannabis and Cannabinoid Use in Breast Cancer Patients During and After Treatments
PROJECT SUMMARY/ABSTRACT Breast cancer patients represent fast-growing medical cannabis and cannabinoid (MCC) users in this country; a recent survey indicates that about 42% of bre...
Targeting APOBEC3A-induced genetic heterogeneity and drug resistance in bladder cancer
PROJECT SUMMARY/ ABSTRACT Every five minutes, a new patient is diagnosed with urothelial carcinoma (UC) in the United States, resulting in the death of 18,000 patients annually. Ne...
Pdcd4-Rictor Interaction in Suppression of Lung Tumorigenesis
Project Summary/Abstract Lung cancer is the leading cause of cancer-related deaths in the United States. The high mortality rate is not only due to the lack of effective early dete...
Role of lipid metabolism in CD8+ T cell ferroptosis
PROJECT SUMMARY Recently, we made a novel and exciting discovery that tumors or the tumor microenvironment (TME) cause T- cell dysfunction and death by inducing ferroptosis in T ce...
Targeting p300 to Overcome PARP inhibitor resistance induced by acidic tumor microenvironment
Project 4 PROJECT SUMMARY/ABSTRACT The overall goal of this proposal is to develop a novel strategy to improve efficacy and/or overcome resistance to PARP inhibitors induced by aci...
Bioinformatics and Biostatistics Core
Core B: Bioinformatics and Biostatistics Core SUMMARY/ABSTRACT The primary goal of the Bioinformatics and Biostatistics Core is to provide centralized biostatistics, bioinformatics...
Pathology Core
Core C: Pathology SUMMARY/ ABSTRACT The individual research projects comprising this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopath...
Germline Genetics and Risk of Prostate Cancer in Diverse Populations from the All of Us Program
PROJECT SUMMARY Prostate cancer is the second most common cancer and the second leading cause of cancer death in US men, with African American men having the highest incidence and...
Shared Resource Core 1: Molecular Data Science and Advanced Dosimetry
PROJECT SUMMARY The convergence of radiation oncology, cancer genomics, data science, computational modeling, and artificial intelligence presents spectacular opportunities and cha...