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Showing 2,3012,320 of 20,252 grants

Completed NON-SBIR/STTR RPGS
Role of protein kinase ADCK5 in ovarian cancer
NATIONAL CANCER INSTITUTE University of Maryland Baltimore County United States 2023 – 2025

Project Summary: Ovarian cancer is the most lethal gynecologic malignancy and the fifth leading cause for cancer-related deaths among women in the United States. Due to the absence...

$1.5M
USD
Active RESEARCH CENTERS
Research Capacity Building Core
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2023 – 2028

The LISTOS Research Capacity Building Core (RCBC) will accomplish the following aims: (1) develop a two-tiered training and mentoring program to build implementation research capac...

Active RESEARCH CENTERS
Research Project 1
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2023 – 2028

PROJECT SUMMARY Colorectal cancer (CRC) is exerting a significant public health impact in Mexico despite the availability of effective screening strategies. Yet, there are no natio...

Active RESEARCH CENTERS
Research Project 2
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2023 – 2028

Implementation of integrated care for rapid breast cancer diagnosis ABSTRACT Consistent with the second pillar of WHO's Global Breast Cancer Initiative for improving breast ca...

Completed NON-SBIR/STTR RPGS
Individualized estimates of treatment benefit from hormone therapy for men with prostate cancer
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2025

Abstract National treatment guidelines, including those from the National Comprehensive Cancer Network (NCCN), for men with localized prostate cancer are based on prostate cancer s...

$3.87M
USD
Active OTHER RESEARCH-RELATED
Privacy-Aware Federated Learning for Breast Cancer Risk Assessment
NATIONAL CANCER INSTITUTE Indiana University Indianapolis United States 2023 – 2028

ABSTRACT: Federated learning (FL) has gained a lot of attention recently, as it enables analyses of data from numerous collaborating sites without the need to share data, i.e., eac...

$7.48M
USD
Completed SBIR-STTR RPGS
Synergize a novel homologous recombination inhibitor with DNA damagingagents in TNBC
NATIONAL CANCER INSTITUTE Creegh Pharmaceuticals, Inc United States 2023 – 2025

15-20% of all breast cancers are triple negative, being devoid of the three receptors that classify and define treatment strategies for most mammary cancers: estrogen receptor (ER)...

$3.99M
USD
Active RESEARCH CENTERS
LISTOS for Cancer Control - Leveraging Implementation Science To Optimize Strategies for Cancer Control
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2023 – 2028

ABSTRACT Populations in Mexico and Latin America experience substantial cancer-related health inequities compared to those in high-income countries. Poor implementation of evidence...

$9.2M
USD
Active RESEARCH CENTERS
Administrative and Engagement Core
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2023 – 2028

ABSTRACT AEC The Administrative and Engagement Core (AEC) of LISTOS support for Cancer Control seeks to administrative, communication, and engagement activities across all Center f...

Active RESEARCH CENTERS
Research Capacity Building Core
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2023 – 2028

The LISTOS Research Capacity Building Core (RCBC) will accomplish the following aims: (1) develop a two-tiered training and mentoring program to build implementation research capac...

Active RESEARCH CENTERS
Research Project 1
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2023 – 2028

PROJECT SUMMARY Colorectal cancer (CRC) is exerting a significant public health impact in Mexico despite the availability of effective screening strategies. Yet, there are no natio...

Active RESEARCH CENTERS
Research Project 2
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2023 – 2028

Implementation of integrated care for rapid breast cancer diagnosis ABSTRACT Consistent with the second pillar of WHO's Global Breast Cancer Initiative for improving breast ca...

Active RESEARCH CENTERS
Implementation Evaluation of a Workplace Self-Sampling HPV Detection Program within the Mexican Social Security Institute
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2023 – 2028

Cervical cancer (CC) is the second leading cause of cancer death among women in Mexico, yet screening participation is alarmingly low, with less than 30% of women aged 20 or older...

$1.27M
USD
Active RESEARCH CENTERS
Administrative and Engagement Core
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2023 – 2028

ABSTRACT AEC The Administrative and Engagement Core (AEC) of LISTOS support for Cancer Control seeks to administrative, communication, and engagement activities across all Center f...

Active SBIR-STTR RPGS
An integrated microfluidic device for patient-derived micro-organospheres
NATIONAL CANCER INSTITUTE Xilis, Inc United States 2023 – 2026

PROJECT SUMMARY/ABSTRACT Functional precision oncology holds great potential to improve the current clinical paradigm by using patient- derived ex vivo systems (e.g., PDXs and orga...

$12.39M
USD
Active NON-SBIR/STTR RPGS
preclinical optimization of BCMA directed T cell therapy
NATIONAL CANCER INSTITUTE Mayo Clinic Arizona United States 2023 – 2028

PROJECT SUMMARY The pillars of multiple myeloma (MM) therapy are DNA alkylators (cyclophosphamide, melphalan), proteasome inhibitors (bortezomib, carfilzomib, ixazomib), glucocorti...

$5.91M
USD
Active NON-SBIR/STTR RPGS
Triboelectric Ambient Mass Spectrometry Imaging of Renal Cell Carcinomas
NATIONAL CANCER INSTITUTE Georgia Institute of Technology United States 2023 – 2026

Principal Investigator: FM Fernández – Triboelectric Ambient Mass Spectrometry Imaging of Renal Cell Carcinomas Understanding complex chemical and biological alterations in cancer...

$1.91M
USD
Active NON-SBIR/STTR RPGS
Randomized Phase II Trial of Prolonged Overnight Fasting and/or Exercise on Fatigue and Other Patient Reported Outcomes in Women with Hormone Receptor Positive Advanced Breast Cancer (FastER)
NATIONAL CANCER INSTITUTE University of Miami School of Medicine United States 2023 – 2028

Abstract More than 40,000 women die each year of metastatic breast cancer. The majority of these tumors are hormone receptor positive (HR+) that are treated with a cyclin dependent...

$7.33M
USD
Active NON-SBIR/STTR RPGS
Pathways of Injury and Repair in Barrett's Carcinogenesis
NATIONAL CANCER INSTITUTE Case Western Reserve University United States 2023 – 2028

PROGRAM SUMMARY The central hypothesis of this program project is that “Altered squamous epithelial integrity (Prj 1) and inflammatory injury (Prj 2) activate signaling pathways in...

$21.12M
USD
Active NON-SBIR/STTR RPGS
Deciphering the Molecular Genetics of VSIG10L in Barrett's Neoplasia
NATIONAL CANCER INSTITUTE Case Western Reserve University United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT The etiology of Barrett's esophagus (BE), a molecularly complex disorder of the distal esophagus, remains elusive. Patients with BE are at an increase...