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20,252 grants found
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Randomized Phase II Trial of Prolonged Overnight Fasting and/or Exercise on Fatigue and Other Patient Reported Outcomes in Women with Hormone Receptor Positive Advanced Breast Cancer (FastER)
Abstract More than 40,000 women die each year of metastatic breast cancer. The majority of these tumors are hormone receptor positive (HR+) that are treated with a cyclin dependent...
Precision Interception of Gastric Cancer Precursors Through Molecular and Cellular Risk Stratification
ABSTRACT – OVERALL Gastric cancer is a leading cause of cancer morbidity and mortality worldwide. The bacterium Helicobacter pylori (Hp) is the single greatest risk factor for gast...
Project 1 - Molecular and Cellular Determinants of High Risk Gastric Precancerous Lesions
ABSTRACT – PROJECT 1 The main objective of Project 1 is to deconvolute the molecular features of high-risk gastric cancer precursor lesions. Dr. Hanlee Ji, Project Leader, previous...
Project 2: Ex Vivo Modeling and Analysis of Gastric Precancerous Lesions
ABSTRACT – PROJECT 2 The central purpose of Project 2 is to utilize a primary human tissue model to investigate the features of gastric stem cells and how the cells interact with H...
K12 Training for Clinical and Translational Oncology Researchers
Abstract: A critical requirement to sustain the rapid advances in clinical oncology research that have been made over the last 20-years is to train and mentor the next generation o...
Integrative Systems Biology Core
PROJECT SUMMARY/ABSTRACT The Integrative Systems Biology Core will interact with all investigators to develop and apply appropriate analysis methods and designs to most efficiently...
Actionable categories of avoidable hospital care among adults with cancer
PROJECT SUMMARY/ABSTRACT Nearly all provider groups in Medicare’s five-year Oncology Care Model alternative payment program expressed a goal to reduce hospital use by cancer patien...
University of New Mexico's CURE for Cancer
ABSTRACT / SUMMARY Responding to community concerns related to higher cancer incidences and worse outcomes among New Mexico’s ethnically and racially diverse communities, the Unive...
Mates in Motion: Feasibility and Acceptability of a Couple-Based Physical Activity Intervention
PROJECT SUMMARY Levels of physical activity (PA) among cancer survivors are low, yet PA may ameliorate difficult effects of treatment. We focus here on PA following the most intens...
Developing a Suite of Targeted Anticancer Drugs
Abstract The stunning clinical success of Gleevec (imatinib) two decades ago appeared to usher in a new era for cancer treatment, whereby a molecular defect in a patient’s tumor wa...
Leveraging whole-exome sequence data from diverse biobanks and cohorts to study rare coding variation in prostate cancer
Abstract There is strong evidence that prostate cancer (PCa) is a heritable phenotype. In addition to greater risk observed in men with a family history of PCa, genome-wide associa...
LISTOS for Cancer Control - Leveraging Implementation Science To Optimize Strategies for Cancer Control
ABSTRACT Populations in Mexico and Latin America experience substantial cancer-related health inequities compared to those in high-income countries. Poor implementation of evidence...
Administrative and Engagement Core
ABSTRACT AEC The Administrative and Engagement Core (AEC) of LISTOS support for Cancer Control seeks to administrative, communication, and engagement activities across all Center f...
An innovative telomerase-targeted, circulating tumor cell assay for monitoring NSCLC treated with radiation and immunotherapy
Project Summary: Cancer is a leading cause of death both in the United States and across the world, claiming over 600,000 and 8 million deaths each year, respectively. Delayed dete...
Development, review, and conduct of Children's Oncology Group (COG) Clinical Trials
Abstract Childhood cancer is the leading cause of disease-related death in children in the United States. The Children’s Oncology Group (COG), one of five clinical trials groups su...
Mental Health CPR: Transforming Cancer Survivors' Mental Health with Community Participatory Reach for Equity
PROJECT SUMMARY Hispanic cancer patients and survivors face social and structural inequalities perpetuating mental health disparities. Despite these challenges, the study team and...
A lung cancer vaccine based on exosomes of induced pluripotent stem cells
A lung cancer vaccine based on exosomes of induced pluripotent stem cells ABSTRACT A critical challenge in lung cancer research is to develop innovative vaccines to protect against...
Tumor downstaging with small molecule therapeutics to enhance Uveal Melanoma metastasis eradication by B7-H3 CAR T cells
Project summaryUveal Melanoma (UM) is a rare cancer with an incidence of 5 cases per million in the United States. Nearly half UM patientsdevelop isolated liver metastases due to t...
Project 3: Molecular Risk Stratification of Gastric Precancerous Lesions
ABSTRACT – PROJECT 3 Project 3 proposes a concerted effort to decrease the 10-15% rate of Helicobacter pylori (Hp) recrudescence that is currently experienced by patients. Previous...
Core A: Administrative
ABSTRACT – ADMINISTRATIVE CORE A The overarching goal of the Administrative Core is to provide the operational support necessary to meet the goals of each Project and the overall P...