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20,252 grants found
Showing 2,261 – 2,280 of 20,252 grants
Use and Impact of Quantitative Information in Tobacco Risk Communications
Project Summary/Abstract In 2019, nearly 14 of every 100 U.S. adults aged 18-years or older (14.0%) currently smoked cigarettes. Current strategies of tobacco use risk communicatio...
Inflammation And Submucosal Glands During Esophageal Injury And Repair
PROJECT SUMMARY The etiology of Barrett's esophagus (BE), a complex metaplastic disorder of the distal esophagus, remains elusive. Patients with BE are at an increased risk of...
EPHB2-Dependent Signaling: A New Molecular Paradigm in Barrett's Neoplasia
PROJECT SUMMARY/ABSTRACT The etiology of Barrett's esophagus (BE), a molecularly complex disorder of the distal esophagus, remains elusive. Patients with BE are at an increase...
Bioreagents & Resources Core
PROJECT SUMMARY The Biospecimen and Reagents Core [BRC] provides high quality annotated specimens and expert pathology consultation to enhance the P01 projects. The BR&C CWRU a...
University of New Mexico's CURE for Cancer
ABSTRACT / SUMMARY Responding to community concerns related to higher cancer incidences and worse outcomes among New Mexico’s ethnically and racially diverse communities, the Unive...
Integrative Systems Biology Core
PROJECT SUMMARY/ABSTRACT The Integrative Systems Biology Core will interact with all investigators to develop and apply appropriate analysis methods and designs to most efficiently...
Project 2: Ex Vivo Modeling and Analysis of Gastric Precancerous Lesions
ABSTRACT – PROJECT 2 The central purpose of Project 2 is to utilize a primary human tissue model to investigate the features of gastric stem cells and how the cells interact with H...
Project 3: Molecular Risk Stratification of Gastric Precancerous Lesions
ABSTRACT – PROJECT 3 Project 3 proposes a concerted effort to decrease the 10-15% rate of Helicobacter pylori (Hp) recrudescence that is currently experienced by patients. Previous...
Core A: Administrative
ABSTRACT – ADMINISTRATIVE CORE A The overarching goal of the Administrative Core is to provide the operational support necessary to meet the goals of each Project and the overall P...
Core B: Translational, Cellular and Molecular Analysis
ABSTRACT – CELLULAR IMAGING AND GENOMICS CORE B Core B, the Cellular Genomics and Imaging Core (CGI), will provide centralized experimental processing services and primary data ana...
Core C: Biostatistics
ABSTRACT – BIOSTATISTICS CORE C The goal of the Biostatistics Core is to provide support for the statistical analysis generated from three projects. These supportive functions incl...
Leveraging whole-exome sequence data from diverse biobanks and cohorts to study rare coding variation in prostate cancer
Abstract There is strong evidence that prostate cancer (PCa) is a heritable phenotype. In addition to greater risk observed in men with a family history of PCa, genome-wide associa...
Probing the role of somatic X-chromosome alterations in shaping cancer sex differences
PROJECT SUMMARY Cancer is a major global public health problem and the second leading cause of death in the United States. Many cancer types display differences in incidence betwee...
Evaluation of the Sensitivity to Endocrine Therapy (SET ER/PR) Assay to predict benefit from extended duration of adjuvant endocrine therapy in the NSABP B-42 trial
ABSTRACT The SETER/PR index of sensitivity to endocrine therapy measures endocrine receptor-related transcription from formalin-fixed paraffin-embedded tumor sections and is highly...
Privacy-Aware Federated Learning for Breast Cancer Risk Assessment
ABSTRACT: Federated learning (FL) has gained a lot of attention recently, as it enables analyses of data from numerous collaborating sites without the need to share data, i.e., eac...
Assessing Benefits and Harms of Medical Cannabis and Cannabinoid Use in Breast Cancer Patients During and After Treatments
PROJECT SUMMARY/ABSTRACT Breast cancer patients represent fast-growing medical cannabis and cannabinoid (MCC) users in this country; a recent survey indicates that about 42% of bre...
Metabolic effects of cooper in renal cancer
Clear cell renal cell carcinoma (ccRCC) is a frequent and malignant renal cancer with a glycolytic phenotype due to the loss of VHL tumor suppressor and activation of HIF transcrip...
Role of BCL11B in lineage ambiguous leukemia
PROJECT SUMMARY Acute leukemias of ambiguous lineage (ALAL) are high-risk leukemia subtypes and include mixed phenotype acute leukemia (MPAL) and early T cell precursor acute lymph...
Precision DNA methylation test to reduce oral cancer disparities in African Americans patients residing in low-resource settings
Project Summary A diagnosis of Head and neck squamous cell carcinoma (HNSCC) includes many cancer subtypes. We will focus on the oral cavity squamous cell carcinoma (OSCC) subtype...
Triboelectric Ambient Mass Spectrometry Imaging of Renal Cell Carcinomas
Principal Investigator: FM Fernández – Triboelectric Ambient Mass Spectrometry Imaging of Renal Cell Carcinomas Understanding complex chemical and biological alterations in cancer...