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20,252 grants found
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Pathways of Injury and Repair in Barrett's Carcinogenesis
PROGRAM SUMMARY The central hypothesis of this program project is that “Altered squamous epithelial integrity (Prj 1) and inflammatory injury (Prj 2) activate signaling pathways in...
Deciphering the Molecular Genetics of VSIG10L in Barrett's Neoplasia
PROJECT SUMMARY/ABSTRACT The etiology of Barrett's esophagus (BE), a molecularly complex disorder of the distal esophagus, remains elusive. Patients with BE are at an increase...
Inflammation And Submucosal Glands During Esophageal Injury And Repair
PROJECT SUMMARY The etiology of Barrett's esophagus (BE), a complex metaplastic disorder of the distal esophagus, remains elusive. Patients with BE are at an increased risk of...
EPHB2-Dependent Signaling: A New Molecular Paradigm in Barrett's Neoplasia
PROJECT SUMMARY/ABSTRACT The etiology of Barrett's esophagus (BE), a molecularly complex disorder of the distal esophagus, remains elusive. Patients with BE are at an increase...
Administrative Core
PROJECT SUMMARY The Administrative Core provides strong, centralized scientific and administrative leadership to the PPG, which facilitates synergistic interactions between the fou...
Bioreagents & Resources Core
PROJECT SUMMARY The Biospecimen and Reagents Core [BRC] provides high quality annotated specimens and expert pathology consultation to enhance the P01 projects. The BR&C CWRU a...
Core B: Translational, Cellular and Molecular Analysis
ABSTRACT – CELLULAR IMAGING AND GENOMICS CORE B Core B, the Cellular Genomics and Imaging Core (CGI), will provide centralized experimental processing services and primary data ana...
Core C: Biostatistics
ABSTRACT – BIOSTATISTICS CORE C The goal of the Biostatistics Core is to provide support for the statistical analysis generated from three projects. These supportive functions incl...
Evaluation of the Sensitivity to Endocrine Therapy (SET ER/PR) Assay to predict benefit from extended duration of adjuvant endocrine therapy in the NSABP B-42 trial
ABSTRACT The SETER/PR index of sensitivity to endocrine therapy measures endocrine receptor-related transcription from formalin-fixed paraffin-embedded tumor sections and is highly...
Probing the role of somatic X-chromosome alterations in shaping cancer sex differences
PROJECT SUMMARY Cancer is a major global public health problem and the second leading cause of death in the United States. Many cancer types display differences in incidence betwee...
Role of BCL11B in lineage ambiguous leukemia
PROJECT SUMMARY Acute leukemias of ambiguous lineage (ALAL) are high-risk leukemia subtypes and include mixed phenotype acute leukemia (MPAL) and early T cell precursor acute lymph...
Mental Health CPR: Transforming Cancer Survivors' Mental Health with Community Participatory Reach for Equity
PROJECT SUMMARY Hispanic cancer patients and survivors face social and structural inequalities perpetuating mental health disparities. Despite these challenges, the study team and...
Broad Genomic Profiling in patients with advanced lung cancer: empirically assessing adoption, clinical utility, and the value of additional evidence in an evolving landscape of cancer care
Personalized cancer treatment is becoming a reality. The real-world adoption of broad genomic profiling (BGP) has enabled the simultaneous testing of hundreds of potentially target...
Functions of mutant IDH in cholangiocarcinoma
PROJECT SUMMARY Isocitrate dehydrogenase 1 is the most frequently mutated metabolic gene across all cancers. Among epithelial malignancies, IDH1 mutations are particularly common i...
preclinical optimization of BCMA directed T cell therapy
PROJECT SUMMARY The pillars of multiple myeloma (MM) therapy are DNA alkylators (cyclophosphamide, melphalan), proteasome inhibitors (bortezomib, carfilzomib, ixazomib), glucocorti...
K12 Training for Clinical and Translational Oncology Researchers
Abstract: A critical requirement to sustain the rapid advances in clinical oncology research that have been made over the last 20-years is to train and mentor the next generation o...
Development of blood-based methylation biomarkers for CRC risk prediction
Development of blood-based methylation biomarkers for CRC risk prediction Colorectal cancer (CRC) incidence and mortality rates are disproportionately higher in African Americans (...
Digital smoking cessation intervention for nationally-recruited American Indians and Alaska Natives: A full-scale randomized controlled trial
PROJECT SUMMARY/ABSTRACT (DESCRIPTION) Since the early 1980s, American Indians and Alaska Natives (AIANs) have maintained the highest rates of commercial cigarette smoking of any r...
An integrated microfluidic device for patient-derived micro-organospheres
PROJECT SUMMARY/ABSTRACT Functional precision oncology holds great potential to improve the current clinical paradigm by using patient- derived ex vivo systems (e.g., PDXs and orga...
Unlocking the Economics of Cancer Control in Uganda Using KeyScope
PROJECT SUMMARY / ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA-23-052. Surgery is the foundation of cance...