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20,252 grants found
Showing 2,221 – 2,240 of 20,252 grants
Regulation of Protein Synthesis in Leukemia Stem Cells
Summary/Abstract Leukemia stem cells (LSCs) promote therapeutic resistance and poor clinical outcomes in acute myeloid leukemia (AML). Central to the function of LSCs is a capacity...
2/2 Collaborative Union for Cancer Research, Education, and Disparities (CURED)
CURED Overall Abstract Dan L Duncan Comprehensive Cancer Center (DLDCCC) at Baylor College of Medicine (BCM) and Texas Southern University (TSU) are jointly submitting a P20 applic...
BCM/TSU P20 Collaborative Union for Cancer Research, Education and Disparities (CURED) Administrative Core (AC)
ABSTRACT – CURED Administrative Core Administrative Core of the proposed BCM-TSU P20 CURED program will serve as a primary administrative unit that oversees the collaborative resea...
Intensive cholesterol-lowering intervention and anti-tumor immunity modeled in prostate cancer
PROJECT SUMMARY In epidemiologic studies, a strong association has been noted between cholesterol-lowering therapy with statins and lower risk of death from prostate cancer. Animal...
1/2 Collaborative Union for Cancer Research, Education and Disparities (CURED)
CURED Overall Abstract Dan L Duncan Comprehensive Cancer Center (DLDCCC) at Baylor College of Medicine (BCM) and Texas Southern University (TSU) are jointly submitting a P20 applic...
Developing and Testing a Culturally Tailored Mobile Health and Social MediaPhysical Activity Intervention Among Adolescent and Young Adult ChildhoodCancer Survivors
ABSTRACT Latinx childhood cancer survivors have an increased risk of cardiometabolic dysfunction. While physical activity (PA) is associated with lower risk of cancer recurrence, c...
Next Generation Gene-Gun Delivered DNA and RNA Immunotherapeutic Vaccines for Melanoma.
PROJECT SUMMARY Orlance has developed a next-generation Gene Gun (MACH-1 GG) that efficiently delivers DNA and RNA into epidermal cells, leading to robust immune responses. Sequenc...
Assigning mode of action to phenotypically discovered anticancer leads.
ABSTRACT. Assigning the mode of action to bioactive compounds is an essential step in drug discovery and a major challenge in chemical biology. This problem is particularly acute f...
Assessing Benefits and Harms of Cannabis and Cannabinoid Use Among a Cohort of Cancer Patients Treated in Community Oncology Clinics
SUMMARY Cancer patients suffer from a multitude of debilitating symptoms associated with cancer and cancer treatment, many of which are not relieved with prescription medications....
Regulation of Protein Synthesis in Leukemia Stem Cells
Summary/Abstract Leukemia stem cells (LSCs) promote therapeutic resistance and poor clinical outcomes in acute myeloid leukemia (AML). Central to the function of LSCs is a capacity...
Intensive cholesterol-lowering intervention and anti-tumor immunity modeled in prostate cancer
PROJECT SUMMARY In epidemiologic studies, a strong association has been noted between cholesterol-lowering therapy with statins and lower risk of death from prostate cancer. Animal...
Next Generation Gene-Gun Delivered DNA and RNA Immunotherapeutic Vaccines for Melanoma.
PROJECT SUMMARY Orlance has developed a next-generation Gene Gun (MACH-1 GG) that efficiently delivers DNA and RNA into epidermal cells, leading to robust immune responses. Sequenc...
2/2 Collaborative Union for Cancer Research, Education, and Disparities (CURED)
CURED Overall Abstract Dan L Duncan Comprehensive Cancer Center (DLDCCC) at Baylor College of Medicine (BCM) and Texas Southern University (TSU) are jointly submitting a P20 applic...
BCM/TSU P20 Collaborative Union for Cancer Research, Education and Disparities (CURED) Administrative Core (AC)
ABSTRACT – CURED Administrative Core Administrative Core of the proposed BCM-TSU P20 CURED program will serve as a primary administrative unit that oversees the collaborative resea...
Developing a Suite of Targeted Anticancer Drugs
Abstract The stunning clinical success of Gleevec (imatinib) two decades ago appeared to usher in a new era for cancer treatment, whereby a molecular defect in a patient’s tumor wa...
A Prospective Cohort Study of Patients with Non-Small Cell Lung Cancer and Multiple Myeloma to Assess the Benefits and Harms Related to Cannabis Use During Treatment
With the majority of Americans supporting legalization of medical cannabis, the number of patients asking their clinicians about medical cannabis has also significantly increased....
Metabolic effects of cooper in renal cancer
Clear cell renal cell carcinoma (ccRCC) is a frequent and malignant renal cancer with a glycolytic phenotype due to the loss of VHL tumor suppressor and activation of HIF transcrip...
Development, review, and conduct of Children's Oncology Group (COG) Clinical Trials
Abstract Childhood cancer is the leading cause of disease-related death in children in the United States. The Children’s Oncology Group (COG), one of five clinical trials groups su...
Investigating tumor-mesothelial cell interactions during ovarian cancer metastasis
PROJECT SUMMARY Ovarian cancer is the leading cause of gynecological cancer-related deaths. The propensity for metastasis is a driving factor for the poor outcomes associated with...
Development of blood-based methylation biomarkers for CRC risk prediction
Development of blood-based methylation biomarkers for CRC risk prediction Colorectal cancer (CRC) incidence and mortality rates are disproportionately higher in African Americans (...