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20,252 grants found
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Genomic and environmental drivers of HCC in Non-Hispanic Blacks: Nature and nurture
Genomicand environmental drivers of HCC in Non-Hispanic Blacks: Nature and nurture: Non-Hispanic Black Americans (Blacks) develop hepatocellular carcinoma (HCC) at about twice the...
TET2-mediated epitranscriptomic regulation in leukemia microenvironment
PROJECT SUMMARY: Background: Acute myeloid leukemia (AML) is one of the most aggressive types of hematopoietic malignancies with various genetic alterations. Ten-Eleven Translocati...
Genomic and environmental drivers of HCC in Non-Hispanic Blacks: Nature and nurture
Genomicand environmental drivers of HCC in Non-Hispanic Blacks: Nature and nurture: Non-Hispanic Black Americans (Blacks) develop hepatocellular carcinoma (HCC) at about twice the...
Extended half-life GlyTR1 combined with checkpoint blockade for Cancer Immunotherapy
Abstract Treatment of non-resectable recurrent/metastatic solid cancers is currently palliative only and there is an urgent unmet need for novel mechanisms of action and additional...
Impact of race and ethnicity on outcomes in patients with hormone receptor-positive breast cancer treated with CDK4/6 inhibitors
Breast cancer (BC) is the most common cancer in women worldwide and is the second leading cause of cancer death in women. However, the advances in outcomes of BC patients have been...
Preclinical and IND enabling studies for treatment of advanced lung cancer and other cancers metastatic to lung by pulmonary delivery of engineered Influenza A Virus (eIAV)
PROJECT SUMMARY / ABSTRACT There are more than 230,000 new cases of lung cancer and over 130,000 deaths due to lung cancer each year in the U.S. Approximately 120,000 people each y...
New Epidemiologic Methods for Reducing Measurement Error and Misclassification Bias in Cancer Epidemiology
Project Summary/Abstract Uncertainty in exposure and outcome measurements poses substantial challenges to the identification and quantification of the causes of cancer. For example...
Chromunities Drive Transcriptional Reprogramming in Humoral Immunity and B-cell Lymphomas
PROJECT SUMMARY/ABSTRACT Diffuse large B-cell lymphomas (DLBCL) arise from B-cells transiting different stages of the germinal center (GC) reaction. It has become clear that these...
Advancing breast cancer risk prediction in national cohorts: the role of mammogram-based deep learning
To date, significant efforts devoted to developing breast cancer risk prediction models that produce modest discriminatory accuracy in the range of 59-68% and underperform in Black...
Engineering Exosome for Pancreatic Cancer Targeting Therapies
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest cancers and ranks fourth in cancer- related deaths in the United States. Therapies for pancreatic cancer are largely...
Adaptation and implementation of a web-based Family centered Adolescent Sperm banking decision Tool for adolescent males with cancer
PROJECT SUMMARY Advances in childhood cancer therapies have resulted in >80% five-year survival rates.1 With nearly 500,000 childhood cancer survivors in the U.S., there is a gr...
Incorporating residential histories into assessment of cancer risk in a predominantly low-income and racially diverse population
PROJECT SUMMARY/ABSTRACTThere is growing recognition that area-level biological and physical exposures associated with residential location across the life-course must be considere...
Developing and Testing a Culturally Tailored Mobile Health and Social MediaPhysical Activity Intervention Among Adolescent and Young Adult ChildhoodCancer Survivors
ABSTRACT Latinx childhood cancer survivors have an increased risk of cardiometabolic dysfunction. While physical activity (PA) is associated with lower risk of cancer recurrence, c...
Effects of Arginine Depletion Combined with Platinum-Taxane Chemotherapy in Aggressive Variant Prostate Cancers (AVPC)
PROJECT SUMMARY/ABSTRACT Androgen indifferent prostate cancers account for a large proportion of the disease lethality and have limited therapy options, partly due to the lack of i...
A novel molecularly targeted theranostic approach via the alphavbeta6 integrin for the detection and treatment of metastatic cancers
PROJECT SUMMARY/ABSTRACT We propose to evaluate a novel αvβ6 integrin molecularly targeted theranostic approach for the detection and treatment of metastatic cancers. The αvβ6 inte...
Racial and social contextual factors in relation to epigenome and bladder cancer outcome.
CURED PILOT Project 2 Summary This proposal entails strengthening the efforts between Dan L Duncan Comprehensive Cancer Center (DLDCCC) at Baylor College of Medicine (BCM) and Texa...
BCM-TSU CURED Cancer Research Education Program (C-REP)
CURED C-REP Summary/Abstract The Collaborative Cancer Research Education Program (C-REP) of the Baylor College of Medicine (BCM)/ Dan L Duncan Comprehensive Cancer Center (DLDCCC)...
Extended half-life GlyTR1 combined with checkpoint blockade for Cancer Immunotherapy
Abstract Treatment of non-resectable recurrent/metastatic solid cancers is currently palliative only and there is an urgent unmet need for novel mechanisms of action and additional...
Novel cell therapy approaches for molecularly defined subsets of therapy-resistant melanoma
PROJECT SUMMARY/ABSTRACT Melanoma (MEL) is a model malignancy for studying the mechanisms of cancer immunotherapy. Antibodies that block negative regulators of T cell function, ter...
Targeted radiation and immunocytokine therapy for CEA positive malignancies
SUMMARY/ABSTRACT Image guided radiotherapy (IGRT) or systemically administered radionuclide therapy are attractive approaches that can perturb the tumor microenvironment (TME) so t...