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20,252 grants found
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Increasing Engagement in Patient Reported Outcome Measurement to Address Breast Cancer Care Disparities using Health Information Technology in Community Cancer Settings
Project Summary/Abstract Major disparities in breast cancer-related outcomes have been widely documented across the cancer care continuum, with Black patients experiencing higher m...
Impact of race and ethnicity on outcomes in patients with hormone receptor-positive breast cancer treated with CDK4/6 inhibitors
Breast cancer (BC) is the most common cancer in women worldwide and is the second leading cause of cancer death in women. However, the advances in outcomes of BC patients have been...
Racial and social contextual factors in relation to epigenome and bladder cancer outcome
CURED PILOT Project 2 Summary This proposal entails strengthening the efforts between Dan L Duncan Comprehensive Cancer Center (DLDCCC) at Baylor College of Medicine (BCM) and Texa...
Adaptation and implementation of a web-based Family centered Adolescent Sperm banking decision Tool for adolescent males with cancer
PROJECT SUMMARY Advances in childhood cancer therapies have resulted in >80% five-year survival rates.1 With nearly 500,000 childhood cancer survivors in the U.S., there is a gr...
Targeting Tryptophan Metabolism in Rectal Cancer
Project Summary/Abstract: More than 40,000 new rectal cancers occur annually in the US and the majority are locally advanced when diagnosed (LARC). Current total neoadjuvant therap...
Incorporating residential histories into assessment of cancer risk in a predominantly low-income and racially diverse population
PROJECT SUMMARY/ABSTRACTThere is growing recognition that area-level biological and physical exposures associated with residential location across the life-course must be considere...
Impact of race and ethnicity on outcomes in patients with hormone receptor-positive breast cancer treated with CDK4/6 inhibitors
Breast cancer (BC) is the most common cancer in women worldwide and is the second leading cause of cancer death in women. However, the advances in outcomes of BC patients have been...
Racial and social contextual factors in relation to epigenome and bladder cancer outcome.
CURED PILOT Project 2 Summary This proposal entails strengthening the efforts between Dan L Duncan Comprehensive Cancer Center (DLDCCC) at Baylor College of Medicine (BCM) and Texa...
In vivo delivery of Ab-directed CRISPR ribonucleoproteins for anal cancer immunotherapy
PROJECT SUMMARY: This year in the US, 9,760 people are expected to be diagnosed with anal cancer. The 5-year survival rate for metastatic anal cancer is only ~30% with standard of...
Preclinical and IND enabling studies for treatment of advanced lung cancer and other cancers metastatic to lung by pulmonary delivery of engineered Influenza A Virus (eIAV)
PROJECT SUMMARY / ABSTRACT There are more than 230,000 new cases of lung cancer and over 130,000 deaths due to lung cancer each year in the U.S. Approximately 120,000 people each y...
Elucidating a novel WNT4 regulatory axis as a driver of gynecologic cancer health disparities
PROJECT SUMMARY/ABSTRACT Gynecologic malignancies such as ovarian cancer (OvCa) are among the deadliest cancers affecting women due to therapy resistance and limited understanding...
Engineering next generation supercharged CAR T-cells against solid tumors
Project summary Adoptive cell therapy has revolutionized cancer treatment and has immense potential to cure a variety of cancer types. Multiple critical barriers exist for current...
New Epidemiologic Methods for Reducing Measurement Error and Misclassification Bias in Cancer Epidemiology
Project Summary/Abstract Uncertainty in exposure and outcome measurements poses substantial challenges to the identification and quantification of the causes of cancer. For example...
Effects of Arginine Depletion Combined with Platinum-Taxane Chemotherapy in Aggressive Variant Prostate Cancers (AVPC)
PROJECT SUMMARY/ABSTRACT Androgen indifferent prostate cancers account for a large proportion of the disease lethality and have limited therapy options, partly due to the lack of i...
Targeted radiation and immunocytokine therapy for CEA positive malignancies
SUMMARY/ABSTRACT Image guided radiotherapy (IGRT) or systemically administered radionuclide therapy are attractive approaches that can perturb the tumor microenvironment (TME) so t...
Advancing breast cancer risk prediction in national cohorts: the role of mammogram-based deep learning
To date, significant efforts devoted to developing breast cancer risk prediction models that produce modest discriminatory accuracy in the range of 59-68% and underperform in Black...
COG NCTN Network Group Operations Center - Year 10 Administrative Supplements
PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60-years ago, the prognosis of childhood cancer has improved dramatically....
Targeting Tryptophan Metabolism in Rectal Cancer
Project Summary/Abstract: More than 40,000 new rectal cancers occur annually in the US and the majority are locally advanced when diagnosed (LARC). Current total neoadjuvant therap...
Chromunities Drive Transcriptional Reprogramming in Humoral Immunity and B-cell Lymphomas
PROJECT SUMMARY/ABSTRACT Diffuse large B-cell lymphomas (DLBCL) arise from B-cells transiting different stages of the germinal center (GC) reaction. It has become clear that these...
Diversity Supplement for R37 Grant
Summary/Abstract This proposal is for a Diversity Supplement to R37CA273232 to support a graduate student Benjamin Kroger. Below is the abstract for the parent award, and as part o...