Browse All Grants
20,252 grants found
Showing 2,141 – 2,160 of 20,252 grants
Core 1: Planning and Evaluation
The goals of the Planning and Evaluation Core (PEC) are to monitor, evaluate, and assess the progress of our U54 Partnerships in meeting its milestones, objectives, and goals. The...
Rwanda CASCADE Clinical Trials Site for cervical cancer prevention
ABSTRACT Cervical cancer is a highly preventable malignancy caused by high-risk human papillomavirus (hrHPV) but is not fully prevented, especially in low- and middle-income countr...
Full Project 2
PIN1 is a cis-trans prolyl isomerase that controls proline-mediated phosphorylation signaling events that is overexpressed both in pancreatic cancer cells and cancer-associated fib...
Core 2: Research Education
Cancer drugs in the United States are almost exclusively developed by, tested in, and optimized for European- Americans. Disparities in U.S. drug development are the result of long...
Pilot-Project 1
University of California, Riverside (UCR) has never implemented a therapeutic trial. Building therapeutic trial capacity at UCR was our biggest challenge – and the biggest failure...
Core 3: Outreach
Our U54 Outreach Core will facilitate the successful translation, implementation, and dissemination of research findings developed by U54 investigators. We build on the community r...
Planning & Evaluation
The goals of the Planning and Evaluation Core (PEC) are to monitor, evaluate, and assess the progress of our U54 Partnerships in meeting its milestones, objectives, and goals. The...
Research Education
Cancer drugs in the United States are almost exclusively developed by, tested in, and optimized for European- Americans. Disparities in U.S. drug development are the result of long...
Outreach
Our U54 Outreach Core will facilitate the successful translation, implementation, and dissemination of research findings developed by U54 investigators. We build on the community r...
Enhanced Viro-Immunotherapy for Breast Cancer Brain Metastasis
PROJECT SUMMARY/ABSTRACT Breast cancer brain metastasis (BCBM) is a major clinical challenge due to their poor response to therapeutic options. Although the survival rate of breast...
UBTF Tandem Duplications in Pediatric Acute Myeloid Leukemia
PROJECT SUMMARY: Children diagnosed with acute myeloid leukemia (AML) continue to have an overall poor outcome with rates of relapse that approach 40%. Relapsed disease is particul...
Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit
PROJECT SUMMARY Liquid biopsy is a clinical test that involves the analysis of various biomarkers present in the blood or other types of body fluids. It enables the detection of ca...
Increasing Participation in NCI-Funded Clinical Trials at Winship Cancer Institute
PROJECT SUMMARY/ABSTRACT I have devoted my career to the improvement of outcomes for patients with lymphoma and have utilized my expertise to improve clinical trial conduct at my h...
Developing a Trustworthy Multilevel Intervention to Improve Equity in Lung Cancer Screening
Modified Project Summary/Abstract Section PROJECT SUMMARY/ABSTRACT Lung cancer screening using low-dose computed tomography significantly reduces lung cancer mortality, the leading...
Metabolic vulnerability due to dysregulated lipid metabolism in PDAC cachexia
PROJECT SUMMARY Cachexia is a devastating complication of cancers and other inflammatory conditions that is defined by rapid and persistent loss of fat and muscle that is not rever...
Comprehensive Assessment of Cancer Theranostics Response
Project Summary Theranostics combines molecular targeted diagnostic and therapeutic radionuclides for imaging and ther- apy in advanced malignancies, with a projected US market of...
Characterizing women living with HIV at cervical cancer diagnosis in Rwanda: Mentored Research under the Rwanda CASCADE Clinical Trials Site
Title: Characterizing women living with HIV at cervical cancer diagnosis in Rwanda: Mentored Research under the Rwanda CASCADE Clinical Trials Site ABSTRACT This application is bei...
Enhanced Viro-Immunotherapy for Breast Cancer Brain Metastasis
PROJECT SUMMARY/ABSTRACT Breast cancer brain metastasis (BCBM) is a major clinical challenge due to their poor response to therapeutic options. Although the survival rate of breast...
Novel cell therapy approaches for molecularly defined subsets of therapy-resistant melanoma
PROJECT SUMMARY/ABSTRACT Melanoma (MEL) is a model malignancy for studying the mechanisms of cancer immunotherapy. Antibodies that block negative regulators of T cell function, ter...
TET2-mediated epitranscriptomic regulation in leukemia microenvironment
PROJECT SUMMARY: Background: Acute myeloid leukemia (AML) is one of the most aggressive types of hematopoietic malignancies with various genetic alterations. Ten-Eleven Translocati...