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20,252 grants found
Showing 2,101 – 2,120 of 20,252 grants
Pilot Project 1
University of California, Riverside (UCR) has never implemented a therapeutic trial. Building therapeutic trial capacity at UCR was our biggest challenge – and the biggest failure...
Core 1: Planning and Evaluation
The goals of the Planning and Evaluation Core (PEC) are to monitor, evaluate, and assess the progress of our U54 Partnerships in meeting its milestones, objectives, and goals. The...
Core 2: Research Education
Cancer drugs in the United States are almost exclusively developed by, tested in, and optimized for European- Americans. Disparities in U.S. drug development are the result of long...
Core 3: Outreach
Our U54 Outreach Core will facilitate the successful translation, implementation, and dissemination of research findings developed by U54 investigators. We build on the community r...
2/2 Drug Development and Capacity Building: A UCR/CoH-CCC Partnership
The United States (U.S.) has led the world in drug discovery for over 50-years. While this is a significant accomplishment, U.S. drugs have been almost exclusively optimized and te...
UBTF Tandem Duplications in Pediatric Acute Myeloid Leukemia
PROJECT SUMMARY: Children diagnosed with acute myeloid leukemia (AML) continue to have an overall poor outcome with rates of relapse that approach 40%. Relapsed disease is particul...
Metabolic vulnerability due to dysregulated lipid metabolism in PDAC cachexia
PROJECT SUMMARY Cachexia is a devastating complication of cancers and other inflammatory conditions that is defined by rapid and persistent loss of fat and muscle that is not rever...
Enhanced Viro-Immunotherapy for Breast Cancer Brain Metastasis
PROJECT SUMMARY/ABSTRACT Breast cancer brain metastasis (BCBM) is a major clinical challenge due to their poor response to therapeutic options. Although the survival rate of breast...
Genomic marker to distinguish aggressive and indolent prostate cancer
ABSTRACT Prostate cancer is the most commonly diagnosed cancer in men, with an estimated 268,490 new cases in the U.S. in 2022. At the time of a prostate cancer biopsy, pathologist...
Increasing Participation in NCI-Funded Clinical Trials at Winship Cancer Institute
PROJECT SUMMARY/ABSTRACT I have devoted my career to the improvement of outcomes for patients with lymphoma and have utilized my expertise to improve clinical trial conduct at my h...
A Patient-Centric Approach to Advance Functional Precision Oncology
PROJECT SUMMARY/ABSTRACT The development of drug resistance is a major cause of cancer treatment failure and mortality. Although much is known about the mechanisms by which tumor c...
Identification of metabolic adducts associated with prostate cancer progression in African American men
Abstract Prostate cancer (PCa) is the second highest cause of cancer-related deaths in men. African American/Black (AA/B) men are disproportionally impacted by PCa with a 60% highe...
Endothelial-Leukocyte Adhesion in CAR T Cell Treatment Associated Neurotoxicity
PROJECT SUMMARY This project studies the mechanism of neurologic toxicity in chimeric antigen receptor (CAR) T cell therapy. CAR T cells are genetically modified, patient derived T...
Multimedia caregiver education program to improve outcomes for children with cancer in low-resource settings
ABSTRACT: Each year, low- and middle-income countries (LMICs) account for over 85% of the 400,000 newly diagnosed pediatric cancer cases. Survival rates in LMICs are 5-25% compared...
Developing and evaluating a mobile application-based intervention to support HPV-tested women and increase their retention to follow-up: a mixed-methods implementation study
PROJECT SUMMARY/ABSTRACT Cervical cancer (CC) is one of the leading causes of cancer death among women from Latin America. In the Region, screening programs face important problems...
TRANSforma Tu Salud Dejando de Fumar: Advancing smoking cessation among transgender individuals
PROJECT SUMMARY Mobile health (mHealth) interventions are a promising modality for overcoming barriers and providing culturally appropriate treatment among transgender individuals....
The Science of Cancer Health Equity for Sexual and Gender Minority Communities
ABSTRACT Sexual and gender minority people (SGM) experience multiple cancer-related disparities, including higher rates of cancer risk factors, lower rates of cancer screening, hig...
Rwanda CASCADE Clinical Trials Site for cervical cancer prevention
ABSTRACT Cervical cancer is a highly preventable malignancy caused by high-risk human papillomavirus (hrHPV) but is not fully prevented, especially in low- and middle-income countr...
Comprehensive Assessment of Cancer Theranostics Response
Project Summary Theranostics combines molecular targeted diagnostic and therapeutic radionuclides for imaging and ther- apy in advanced malignancies, with a projected US market of...
An Aptamer-directed IgG1-Fc Drug Conjugate (AFDC) for Treating Pancreatic Cancer
Abstract Pancreatic ductal adenocarcinoma (PDAC) ranks the seventh in causing cancer-related death among all human cancers with very poor prognosis and horrendous survival rate. De...