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20,252 grants found
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SBIR Topic #446 Phase I -Development of Senotherapeutic Agents for Cancer Treatment
Cancer therapies that harness the immune system are best positioned to improve long-term survival, but current immunotherapeutics suffer from nonresponse, resistance, and toxicity....
PHARMACOKINETIC AND ORAL BIOAVAILABILITY STUDIES IN RATS
The purpose of this task order is to identify suitable formulations for administration of potential drug candidates to rats for early pharmacokinetic studies and to characterize th...
PROTOCOL INFORMATION OFFICE (PIO) SUPPORT SERVICES FOR THE PROCESSING OF CLINICAL TRIAL PROTOCOL DOCUMENTS AND TRACKING THE IMPLEMENTATION AND COMPLETION OF HUMAN CLINICAL RESEARCH STUDIES. PERFORMANC
The major objective of this requirement is to provide support, which is defined by the five project areas detailed below, to the NCI, DCP Protocol Information Office (PIO). The fiv...
THE SIXTH PHASE OF THE AGRICULTURAL HEALTH STUDY CONTRACT
The Agricultural Health Study (AHS) is a prospective study of cancer and other health outcomes in addition to cancer in a cohort of licensed pesticide applicators and their spouses...
Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit
PROJECT SUMMARY Liquid biopsy is a clinical test that involves the analysis of various biomarkers present in the blood or other types of body fluids. It enables the detection of ca...
Point of Care HPV 16/18/45 DNA Test for Cervical Cancer
Point of Care HPV 16/18/45 DNA Test for Cervical Cancer. CrossLife Technologies Inc. Project Summary/Abstract Human cervical cancer is the fourth most common cancer among women wor...
Developing a Trustworthy Multilevel Intervention to Improve Equity in Lung Cancer Screening
Modified Project Summary/Abstract Section PROJECT SUMMARY/ABSTRACT Lung cancer screening using low-dose computed tomography significantly reduces lung cancer mortality, the leading...
Prospective metabolomics investigation of gastric cancer risk in African Americans and European Whites with a low socioeconomic status
ABSTRACT Gastric cancer is one of the most common and deadly cancers globally, accounting for over one million new cancer diagnoses and 783,000 deaths in 2018. Infection of Helicob...
Elucidating novel epigenetic modifications implicated in multiple myeloma risk disparities
PROJECT SUMMARY Multiple myeloma (MM), the second most common hematologic malignancy in the United States, is an incurable plasma cell malignancy with standardized incidence rates...
SUPPORT SERVICES FOR INTEGRATIVE EPIDEMIOLOGICAL STUDIES
Chile Biliary Longitudinal Study (BiLS)The Chile BiLS is a cohort of women with gallstones in Chile, which has among the highest rates of gallbladder cancer (GBC) in the world. By...
Base Title: PREVENT Preclinical Pharmacology and ToxicologyTask Order Title: Nicotine Reduction Therapy Using the Human Monoclonal Antibody ATI-1013
The objectives of this Task Order are to: 1. Determine the cross-reactivity of ATI-1013 in major organs/tissues of humans, rats, dogs, and non-human primates. 2. Assess immunogenic...
CHARACTERIZING THE MECHANISM OF ACTION (MOA) OF INVESTIGATIONAL/APPROVED CANCER AGENTS
The Division of Cancer Treatment and Diagnosis (DCTD), NCI, is requesting support to develop capability for performing molecular mechanistic studies of approved and investigational...
Endothelial-Leukocyte Adhesion in CAR T Cell Treatment Associated Neurotoxicity
PROJECT SUMMARY This project studies the mechanism of neurologic toxicity in chimeric antigen receptor (CAR) T cell therapy. CAR T cells are genetically modified, patient derived T...
Optogenetic engineering of tumor topography in native tissue environments
Project Summary: In nearly every cancer, tumors demonstrate a predilection for certain locations within a tissue and this is associated with unique clinical phenotypes. For example...
Tracking the Mechanisms of Adaptation to Autophagy Inhibition
SUMMARY Acquired resistance to anti-cancer therapeutics has proven to be one of the largest hurdles in cancer cell biology because cancer cells have the remarkable ability to adapt...
1/2 Drug Development and Capacity Building: A UCR/CoH-CCC Partnership
The United States (U.S.) has led the world in drug discovery for over 50-years. While this is a significant accomplishment, U.S. drugs have been almost exclusively optimized and te...
Administrative Core
The Administrative Core is led by the U54’s Principal Investigators, Ernest Martinez, Ph.D. (PI, University of California, Riverside [UCR]) and Victoria Seewaldt, M.D. (PI, City of...
Core 4: Shared Resource - Capacity Development
It is challenging to build successful research collaborations. Successful collaborations are even more challenging when working across institutions and with early-stage investigato...
Project 1
Most luminal B breast cancers (LBBC; ER+, HER2-wt, Ki67>14%) carry a good prognosis. However, approximately 20% of LBBC are highly aggressive and resistant to current therapies....
Project 2
PIN1 is a cis-trans prolyl isomerase that controls proline-mediated phosphorylation signaling events that is overexpressed both in pancreatic cancer cells and cancer-associated fib...