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20,252 grants found
Showing 2,041 – 2,060 of 20,252 grants
Discovery of a novel MDM2-tubulin signaling pathway as a therapeutic target in AML
Project Summary/Abstract Acute myeloid leukemia (AML) continues to have a dismal 5-year survival rate of
A framework for integrating MR imaging and clinical tests for prediction of outcomes in multiple myeloma treatment
Abstract Multiple myeloma (MM) is the second most common hematologic malignancy (after non-Hodgkin lymphoma) in the U.S. Over the past decade, despite the advent of novel therapies...
Induction of interferon response by chromatin damaging anti-cancer therapy
Abstract. DNA-targeting drugs are a mainstream therapy for cancer, but it is becoming clearer that some of their anti-cancer activity is due not only to DNA damage, but also chroma...
Interrogating Type I Interferon signaling in breast cancer brain metastasis
PROJECT SUMMARY The brain is one of the common organs for breast cancer recurrence. Breast cancer brain metastasis is increasingly becoming a significant clinical problem due to it...
33rd International Workshop on Retroviral Pathogenesis
Project Summary/Abstract The International Workshop on Retroviral Pathogenesis, now in its 33rd year, has long served as a forum for the exchange of new research findings and conce...
Exploring SGLTs as Theranostic Targets for Cancer Metastasis
Project Summary/Abstract: Exploring SGLTs as Theranostic Targets for Cancer Metastasis Cancer requires substantial energy that is commonly provided by increased glucose transport a...
Acupuncture for Chemothrapy-induced Peripheral Neuropathy Treatment (ACT) Trial
Project Summary One of the most harmful side effects of chemotherapy is chemotherapy-induced peripheral neuropathy (CIPN), a common, painful, and disabling side effect of many chem...
Precision Approaches to Treat Mantle Cell Lymphoma: Integrating Multi-omics Based Models
Project Summary Mantle cell lymphoma (MCL) is a rare, incurable form of non Hodgkin lymphoma which is disposed to therapeutic resistance and relapse. Though rare, MCL is both clini...
Targeting OSCC cells with a lozenge to treat oral cancer
Abstract/Summary Oral cancer kills over 8,000 people in the USA and 120,000 people worldwide every year. Over 90% of oral cancers are caused by oral squamous cell carcinoma (OSCC),...
The role of sympathetic nerve associated macrophages during pancreatic adenocarcinoma progression
Abstract Pancreatic ductal adenocarcinoma (PDAC) has the highest mortality rate of all major cancers. While immunotherapy has revolutionized treatment for numerous cancers, such tr...
BET degraders for improving colorectal cancer therapy
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the US. Developing novel and more effective CRC therapies is an unmet biome...
BET degraders for improving colorectal cancer therapy
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the US. Developing novel and more effective CRC therapies is an unmet biome...
A precision medicine basis for estrogen therapy for advanced breast cancer
Project Summary: It remains unknown why some estrogen receptor alpha (ER)-positive breast cancers are sensitive to estrogen therapy while others are resistant, and strategies for e...
A precision medicine basis for estrogen therapy for advanced breast cancer
Project Summary: It remains unknown why some estrogen receptor alpha (ER)-positive breast cancers are sensitive to estrogen therapy while others are resistant, and strategies for e...
Role of PDK1 in pancreatic cancer cell fitness under tumor nutrient stress
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type in urgent need of more effective treatment options. A notable feature of PDAC tumors is t...
PROVIDE A VARIETY OF CRITICAL CANCER PREVENTION INFORMATION MANAGEMENT FUNCTIONS
THE PURPOSE OF THE ACQUISITION IS TO PROVIDE A VARIETY OF CRITICAL CANCER PREVENTION INFORMATION MANAGEMENT FUNCTIONS NECESSARY TO SUPPORT THE IDENTIFICATION, DEVELOPMENT, AND QUAL...
THE PURPOSE OF THIS REQUIREMENT IS TO PROVIDE REGULATORY SERVICES AND TECHNICAL SUPPORT TO THE DIVISION OF CANCER PREVENTION (DCP) AT THE NATIONAL CANCER INSTITUTE (NCI). NCI AND DCP HAVE A RECURRING
THE PURPOSE OF THIS REQUIREMENT IS TO PROVIDE REGULATORY SERVICES AND TECHNICAL SUPPORT TO THE DIVISION OF CANCER PREVENTION (DCP) AT THE NATIONAL CANCER INSTITUTE (NCI).
Conserved coamplification event in HER2+ breast cancer increases metastasis
PROJECT SUMMARY Breast cancer is the most common cancer diagnosed among women and is estimated to be the leading cause of death for women worldwide. Approximately one fifth of brea...
FY23 FACILITIES TO C-WESTLAKE REFURBISHMENT
Building 560 is a 183,548 sq. ft. masonry and steel structure constructed in 1956. This project will refurbish Wing 2, Floor 2 of Building 560, specifically Room Nos. 22-31, 22-56...
Targeting a Novel Pocket on ITGAV
Project Summary. Cancer deaths remain at an all-time high in the United States leaving an urgent clinical need to develop novel therapeutic strategies to help patients. The lack of...