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20,252 grants found
Showing 2,021 – 2,040 of 20,252 grants
Uncovering the Role of RNA Modifications in the Paraspeckle
PROJECT SUMMARY RNA modifications are chemical changes made to transcripts that can regulate their processing, structure, and stability. Recent advances in modification detection t...
Metabolic Obesity Phenotypes and Obesity-related Cancer Survival
PROJECT SUMMARY. The incidence of obesity-related cancer (ORC) continues to increase rapidly despite a decrease in overall cancer incidence; currently ORCs constitute over 40% of a...
Synthetic manipulation of engineered perivascular niches
ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 23-045. Glioblastoma (GBM) is the most common and lethal for...
Molecular Phenotyping and Image-Guidance for Surgical Treatment of High-Risk Prostate Cancer Using Ultrasmall Silica Nanoparticles
Project Summary: High-risk prostate cancer (PC) is the second most common cause of cancer-related death in men. Improvements in overall survival and long-term morbidity will depend...
Targeting PGC1β/PPARγ axis for overcoming acquired resistant to third generation EGFR-TKIs
SUMMARY Epidermal growth factor receptor (EGFR)-targeted therapy with EGFR tyrosine kinase inhibitors (EGFR-TKIs), particularly current third generation mutation-selective agents s...
Enhancing the efficacy of immunotherapy by optimal use of SMAC mimetics
PROJECT SUMMARY Shenqqing (Stan) Gu, Ph.D., is an experimental-computational biologist whose career goal is to develop personalized strategies for optimal combination immunotherapy...
Pathogenic Role of Foxl1+ Hepatic Progenitor Cells in Fibrotic Liver Disease
PROJECT SUMMARY/ABSTRACT Progression of chronic liver disease to fibrosis, cirrhosis, and cancer is the common course of several liver diseases, but treatments for the end-stage li...
Hormone signaling and translation control in advanced prostate cancer
ABSTRACT (from parental grant) The recent advent of highly potent inhibitors of the androgen receptor and androgen biosynthesis has had the unfortunate iatrogenic effect of fueling...
Combining senescence-inducing and senolytic agents to improve melanoma therapy
Contact PD/PI: Vilgelm, Anna E Project Summary Metastatic melanomas are aggressive tumors that respond poorly to chemotherapy and radiation and promptly acquire resistance to targe...
Combinational Targeting the Feed-forward Epigenetic Circuitry in Mixed Lineage Leukemia
PROJECT SUMMARY N/A Project Summary/Abstract
Boosting IL-12-induced anti-glioblastoma activity via immunotherapeutic extracellular vesicles.
PROJECT SUMMARY The objective of this application is to develop the career of Dr. Breyne, facilitating his transition to a stable, independent phase and establishing his research p...
Ligand-directed therapeutic CRISPR/Cas gene editing in tumor cells
ABSTRACT The human body is composed of at least 400 different cell types, each distinguishable by distinct cellular markers. Cancer cells also express distinct cellular markers, di...
Development of Caspase Cleavage Targeting Chimeras (CACTACs) for Targeted Protein Cleavage
PROJECT SUMMARY Caspases are a family of cysteine proteases which can cleave proteins containing cleavage sites on the flexible region to trigger cell death through apoptosis or py...
Development of a novel, CNS-penetrant synthetic triterpenoid for pediatric high-grade glioma.
PROJECT ABSTRACT This application is focused development of a new therapeutic for pediatric high-grade glioma (HGG), including a rare subset known as Diffuse Intrinsic Pontine Glio...
Identification and characterization of genetic risk factors in pediatric brain tumors
PROJECT SUMMARY Brain tumors are the most common form of cancer in children between 0-19-years of age in the United States, and are the largest cause of cancer-related deaths. Our...
Novel TCR transgenic mice to study tumor neoantigen-specific T cell responses
PROJECT SUMMARY Activated CD8+ T cells are capable of responding to tumor neoantigens and can aid in the clearance of tumors. Indeed, CD8+ T cells are critical for the beneficial e...
Rational targeting of Cdc42 to benefit immunotherapy
ABSTRACT T cells play important role in cancer cell immunosuppression. Cancer cells can interact with immune checkpoint proteins expressed on effector T cells to cause T cell exhau...
Pyk2 regulates extracellular vesicles release in GBM cells and modulates activation of tumor infiltrating myeloid cells
Glioblastoma (GBM) is the most aggressive brain cancer and usually fatal within a year after diagnosis. Current treatment approaches provide only a modest, few months, life extensi...
c-Myc regulation by TGF-beta signaling as a therapeutic target in Osteosarcoma
PROJECT SUMMARY Osteosarcoma (OS) is an aggressive malignant primary bone cancer with a high propensity for lung metastasis. Since the development of aggressive chemotherapy and su...
Targeting ULK3 for the treatment of triple negative breast cancer
PROJECT SUMMARY / ABSTRACT Clinical significance: Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and represents 15-20% of new cases (1). Given...