Browse All Grants
20,252 grants found
Showing 20,181 – 20,200 of 20,252 grants
Impact of the microbiome on chemotherapeutic outcomes
PROJECT SUMMARY/ABSTRACT Cytotoxic chemotherapeutic agents are a key component of cancer therapy, but they have unpredictable treatment responses and considerable treatment-related...
DNA-based Immune Phenotyping in HNSCC for Biomarkers of Response to Immunotherapy
PROJECT SUMMARY/ABSTRACT Head and Neck Squamous Cell Carcinomas (HNSCCs) are devastating upper airway tumors that are associated with an immunosuppressive network impacting the tum...
Investigating mechanisms underscoring dichotomous T cell responses between medulloblastoma subgroups
PROJECT SUMMARY/ABSTRACT (30 lines of text): Medulloblastomas are one of the most common childhood brain tumors and are comprised of several histological and molecularly distinct s...
Impact of heme catabolism on triple negative breast cancer metastasis via immune-suppression
Abstract/Project Summary Triple negative breast cancer (TNBC) has more frequent and rapid metastasis than other breast cancer (BC) subtypes and >20% of patients progress on stan...
Elucidating Oncogenic Mechanisms Underlying Wilms Tumor Using Kidney Organoids
PROJECT SUMMARY/ABSTRACT Wilms tumor is the most common pediatric kidney cancer.Blastemal-predominant tumors are classified as high-risk and have demonstrated resistance to chemoth...
A novel polymer-metal nanocomplex for ovarian cancer treatment
Summary: Ovarian cancer is the leading cause of death from gynecologic malignancy.Most women are diagnosed with metastatic ovarian cancer, and the 5-year survival rate for this lat...
A deubiquitination module controls Treg adaptation to tumor microenvironment
Project Summary: One of the recent advances in cancer treatment is the development of immunotherapy largely through targeting the checkpoint receptors. However, attempts at immunot...
Strategies to target BCR-ABL1 compound mutants in CML and Ph+ ALL
Abstract: Philadelphia chromosome-positive (Ph+) leukemia is caused by BCR-ABL1, a constitutively active fusion kinase.Tyrosine kinase inhibitors (TKIs) targeting the ATP site of B...
Characterizing the effects of cis-regulatory variation on patient outcomes and treatment response in Multiple Myeloma
ABSTRACT Multiple Myeloma (MM) is a malignancy of plasma cells and the second most common hematological cancer accounting for 2% of cancer deaths.MM is associated with a poor progn...
Development of Glypican-2 redirected T cells for the Treatment of Neuroblastoma
Project Summary The objective of this proposal is to develop a T cell-based immunotherapy for the treatment of high-risk neuroblastoma (NB), for which outcomes remain poor.The adop...
Modeling myelodysplasia
PROJECT SUMMARY Myelodysplastic Syndromes (MDS) are a cancer of the hematopoietic stem cell (HSC) on the rise in the aging population and cancer survivors.The only curative treatme...
Modeling Immune Cell Recruitment and its Impact on Triple Negative Breast Cancer Recurrence in the Irradiated Microenvironment
PROJECT SUMMARY Approximately half of triple negative breast cancer (TNBC) patients receive breast conserving therapy, which includes irradiating the primary tumor site.Although th...
CD25-mediated feedback control of BCR-signaling and its oncogenic mimics
PROJECT SUMMARY B cells critically depend on continuous survival and proliferation signals from a functional B cell receptor (BCR). Likewise, in ~50% of B cell malignancies, the tu...
Dissecting the mechanistic role of multinucleation in breast and trophoblast cancers
Project Summary/Abstract A key driver of cancer is the global deregulation of transcription networks in the cell.Transcriptional output is dependent on chromatin structure and topo...
In vivo Drug Testing of Pediatric CNS Tumors Using Patient Derived Orthotopic Xenograft Models
PROJECT SUMMARY/ABSTRACT This application is prepared for an extension of our previously funded research proposal that was in response to RFA-CA-14-018, Pediatric Preclinical Testi...
Disparities in the Use of Oral Anticancer Agents in Kidney Cancer
We have long known that real-world black-white racial disparities have existed in the treatment and outcomes of patients with renal cell carcinoma (RCC).However, it is unclear how...
The novel role of microtubule regulators in the DNA damage response
DNA damage, particularly DNA double strand break (DSB), has detrimental effects on cell survival and genomic stability. In response to DNA damage, the cell activates several evolut...
Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy
Abstract In the United States, colon cancer and rectal cancer are the third most common cancer diagnosed in both men and women. The standard of care for stage II-III rectal cancer...
Targeted activation of autoimmune checkpoints in B cell malignancies
Targeted therapy of cancer typically focuses on agents that suppress oncogenic signaling below a minimum threshold needed for survival and proliferation.Here, we propose a novel st...
Identifying primary targets of bumped kinase inhibitor derived compounds to improve utility as therapy for castration resistant prostate cancer
Project Summary/Abstract Castration-resistant prostate cancer (CRPC) that inevitably escapes primary therapies most often retains dependency on androgen receptor (AR). We are repos...