Browse All Grants
20,252 grants found
Showing 2,001 – 2,020 of 20,252 grants
Next-generation SMARTs for Discovery and Evaluation of Sequential Cancer Therapeutic Strategies
Treatment of cancer is an ongoing process during which clinicians make a series of decisions at critical points in a patient's disease by synthesizing baseline and evolving pa...
Targeting cancer cachexia drivers using antibody-based approaches
PROJECT SUMMARY Cancer-associated cachexia is a debilitated syndrome that has a dramatic impact on the quality of life and outcome of patients. Cancer cachexia occurs with a remark...
Investigating the hnRNPA18-HIF-1a axis in solid tumors
PROJECT SUMMARY Therapeutic approaches in cancer therapies have evolved from the use of highly toxic chemotherapy agents to precision medicine with well-defined targets and minimal...
First in Class Small molecules to simultaneously inhibit protein translation and an immune checkpoint in cancers
PROJECT SUMMARY Therapeutic approaches in cancer therapies have evolved from the use of highly toxic chemotherapy agents to precision medicine with well-defined targets and minimal...
Development of novel AAV vaccine strategy in a pre-clinical model of oral melanoma.
Project Summary/Abstract Vaccination is a potent regulator of the immune system and much research is being conducted to understand how antigen-specific stimulation can be used to i...
Targeting Immune Escape in CML/MPN Transformation
Myeloid neoplasms such as chronic myelogenous leukemia (CML) and myeloproliferative neoplasms (MPN) may over time transform from a chronic phase (CP) into, respectively, blast cris...
Quantitative evaluation of focused ultrasound thermal therapy on immunogenic cell death in breast cancer
Triple negative breast cancer (TNBC) is resistant to conventional therapies, leading to poor disease-free survival and high recurrence rates. However, in contrast to other breast c...
Targeting Protein Arginine Methyltransferases to Eradicate Acute Myeloid Leukemia
Project Summary Treatment outcomes for patients with acute myeloid leukemia (AML) have continued to lag behind outcomes reported for other hematological malignancies like acute lym...
2023 SoCal Genome Stability Symposium
ABSTRACT The 2023 SoCal Genome Stability Symposium is a one-day conference that will be held at the University of Southern California, Los Angeles. The conference will focus on gen...
Role of DeltaNp63 alpha and TIP60 in SCC progression and chemoresistance
PROJECT SUMMARY / ABSTRACT Cisplatin is frequently used to treat squamous cell carcinoma (SCC), frequently in combination with other drugs or ionizing radiation (IR). Tumor recurre...
The mammary cell secretome as a novel biologic for triple-negative breast cancer
SUMMARY Breast cancer accounts for nearly a quarter of all cancers in women and it remains the second leading cause of cancer deaths in the US, despite substantial changes in stand...
Novel ctDNA biomarker for androgen therapy in metastatic prostate cancer
PROJECT SUMMARY The deadliest form of advanced-stage prostate cancer is treatment-resistant metastatic castration- resistant prostate cancer (mCRPC), which occurs in ~35% of patien...
Causes and Consequences of Whole Genome Duplication in Cancer Progression and Acquired Drug Resistance
Summary Recent studies show that whole genome duplication (WGD) is a frequent event in cancer evolution that promotes chromosomal instability and aneuploidy. WGD tumors have worse...
Computational Feature Profiling and Modeling for Prostate Cancer Detection and Risk Stratification
PROJECT SUMMARY/ABSTRACT Prostate cancer is the most common and second deadliest non-skin cancer in American men, accounting for 26% of new cancer diagnoses and 9% of cancer deaths...
Targeting FGFR4 to overcome chemoresistance in ovarian cancer
Abstract Many anti-tubulin agents, such as paclitaxel (Taxol), have been used extensively for treatment of several types of cancer, including ovarian, lung, and breast cancers. Des...
Development of an Efficient 18F labeling technology based on tetrazine trans-cyclooctene ligation
Abstract: Proposed is the development of readily available tools for radiochemistry based on tetrazine ligation— a bioorthogonal reaction with rapid kinetics that has been studied...
Covalent PD1 Antagonists: Discovery of Protein-Protein Interaction (PPI) Inhibitors in Cancer Immunotherapy
7. Project summary. Protein–protein interactions (PPIs) play a pivotal role in regulating a plethora of biological processes and their misregulations have been associated with a va...
Tetraacylated lipid A enhancement of checkpoint blocking cancer immunotherapy
PROJECT SUMMARY Immune checkpoint inhibitor (ICI) therapy is a therapeutic approach that blocks pathways that inhibit anti-tumor immunity and activates the immune system to fight c...
Exploring the Impact of Genetic Ancestry on Acute Lymphoblastic Leukemia Risk in Latino Populations
PROJECT SUMMARY/ABSTRACT The overarching goal of this proposal is to employ and refine state-of-the-art gene discovery methods to uncover the genetic etiology of Acute Lymphoblasti...
Defining the mechanisms by which NuMA drives spindle mechanical robustness
Project Summary/Abstract Errors in chromosome segregation lead to aneuploidy, a hallmark of cancer where daughter cells have extra or missing chromosome copies. Spindle pole defect...