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20,252 grants found
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Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
This proposal brings together a unique interdisciplinary team with complementary expertise in high-LET radiobiology, pancreatic cancer research, and high-LET physics.It leverages t...
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity
Durable outcomes in subsets of solid cancer patients treated with immune checkpoint inhibitors (ICI) or adoptive cell transfer (ACT) immunotherapy has driven interest in gaining a...
Establishing smoke-free homes with families involved in child protective services: An effectiveness-implementation trial of an integrated program
Project Abstract Child exposure to secondhand smoke (SHS) is linked to multiple forms of cancer throughout the lifespan. Young children living in low-socioeconomic status household...
Testing a culturally targeted narrative video to reduce disparities in the use of genetic counseling and testing in Latina women at-risk of HBOC
ABSTRACT National guidelines recommend that women at increased risk for Hereditary Breast and Ovarian Cancer (HBOC) due to BRCA1/2 mutations be referred for genetic counseling and...
Two-Dimensional Multi-Stage Isotachophoretic Technology for Multiplex Analysis of Cancer Exosomes and Proteins Marker Panel
Abstract Exosomes are small-sized (30?120 nm) extracellular vesicles.They are secreted by most cell types and play important roles in extracellular communication in normal and path...
A Randomized Controlled Trial: Genetic Counseling Patient Preference Intervention via Electronic Health Record Portal vs. Conventional Genetic Counseling for Women at Elevated Risk for Breast Cancer
PROJECT SUMMARY Women at elevated risk for breast cancer should complete genetic counseling and may require more frequent screening or additional tests (e.g. breast magnetic resona...
Normalizing aberrant metabolism in ovarian cancer by a unique drug delivery system
Gene silencing using small interfering RNA (siRNA) is a viable therapeutic approach but, limited in translation due to lack of effective delivery systems. Developing effective and...
Defining the role of Mst1/Mst2 in regulating metabolic alterations in Ras driven NSCLC
PROJECT SUMMARY/ABSTRACT Non-small cell lung cancer (NSCLC) remains the most commonly diagnosed malignancy and leading cause of cancer related deaths worldwide; yet there is a fund...
Therapeutic Targeting Mitochondrial C1 Metabolism
ABSTRACT Metabolic reprogramming is an important hallmark of cancer. Of the altered metabolic pathways associated with malignancy, one-carbon (C1) metabolism is particularly notabl...
Exploiting convergent evolution to design biomarker extraction tools for the prediction of therapeutic response in cancer
PROJECT SUMMARY/ABSTRACT The effective treatment of drug resistant tumors represents one of the greatest unmet needs in oncology research.The evolution of therapeutic resistance in...
Tuning CAR-T cell function
Abstract Chimeric antigen receptors (CAR) expressed by T cells recognize tumor cells via single chains antibodies and activate T cell cytotoxic machinery and costimulation.In clini...
Role of SerpinB3 in glioblastoma cancer stem cells
Project Summary ROLE OF SERPINB3 IN GLIOBLASTOMA CANCER STEM CELLS Glioblastoma (GBM) is the most aggressive primary malignant brain tumor, with a median survival of 18-20 months.D...
The role and regulation of p53 in obesity-induced liver cancer
Project Summary/Abstract Obesity is a prevalent global health problem, and it increases the overall risks of many types of chronic diseases and cancers.Nonalcoholic steatohepatitis...
The role of type 1 dendritic cells in CD4 and CD8 T cell anti-tumor immunity
PROJECT SUMMARY Cancer immunotherapies have revolutionized the treatment of malignancies, but these therapeutics still face enormous challenges and limited efficacy in many patient...
Telomerase-Mediated Healing of Double-Strand Breaks in Human Cells
PROJECT SUMMARY/ABSTRACT Telomeres?which define and protect the ends of humans? linear chromosomes?serve as a natural check on carcinogenesis.Genome stability requires cells to dif...
Discovery of myeloid immune features predictive of response to cancer immunotherapy in prostate cancer
PROJECT SUMMARY/ABSTRACT Cancer immunotherapy has been a revolutionary antitumor treatment and is approved to treat a plethora of cancer types.However, in solid tumors the response...
Determining the Mechanism of Transformation for Rhabdomyosarcoma
ABSTRACT Rhabdomyosarcoma (RMS) is an aggressive, soft-tissue sarcoma in children.While many clinical trials have worked to improve patient outcomes, the 3-year survival rate for h...
Studies of the structural and functional basis of neuroblastoma drug resistance
PROJECT SUMMARY/ABSTRACT Neuroblastoma is the most common extracranial tumor of young children, and the five-year overall survival of children with high-risk disease is less than 5...
Population-Targeted Risk Prediction to Guide Breast Cancer Screening in Cameroon
Project Summary/Abstract: As cancer becomes an increasingly important cause of mortality in sub-Saharan Africa, nations must improve their capacity to diagnose and treat the malign...
Brachytherapy to achieve in situ cancer vaccination
Project Summary/Abstract We aim to improve the cure rates for metastatic cancers.To achieve this we propose a combined modality approach to stimulate and diversify an endogenous an...