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20,252 grants found
Showing 20,141 – 20,160 of 20,252 grants
Identifying new drivers of ovarian cancer from the non-coding genome by converging germline risk variants and somatic mutations
PROJECT SUMMARY/ABSTRACT The goal of the proposed research training program is to provide tailored additional training to facilitate successful career development throughout the co...
Exploiting convergent evolution to design biomarker extraction tools for the prediction of therapeutic response in cancer
PROJECT SUMMARY/ABSTRACT The effective treatment of drug resistant tumors represents one of the greatest unmet needs in oncology research. The evolution of therapeutic resistance i...
Optimizing Colorectal Cancer Screening among Patients with Diabetes in Safety-Net Primary Care Settings: Targeting Implementation Approaches
ABSTRACT Patients with diabetes mellitus have an estimated 27% elevated risk of developing colorectal cancer (CRC) and are disproportionately Non-Hispanic blacks (NHBs) and Hispani...
X-ray/optical tomographic guidance and assessment for pre-clinical radiation Research
PROJECT SUMMARY/ABSTRACT Over the past 10-years, our group has made multi-disciplinary efforts to bridge the technological gap between radiation methods for human treatment and pre...
Eradication of Escaped Variant Tumor Cells for Cancer Immunotherapy
Project Summary Recently, we discovered that adoptive transfer of CD39KO tumor-specific (mixed CD4+ and CD8+) T cells, resulted in long-term survival of mice bearing large establis...
The novel role of microtubule regulators in the DNA damage response
DNA damage, particularly DNA double strand break (DSB), has detrimental effects on cell survival and genomic stability. In response to DNA damage, the cell activates several evolut...
The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
PROJECT SUMMARY The incidence of esophageal adenocarcinoma (EAC) has risen 10-fold over the past half century and continues to have a dismal prognosis. Known modifiable risk factor...
The novel role of microtubule regulators in the DNA damage response
DNA damage, particularly DNA double strand break (DSB), has detrimental effects on cell survival and genomic stability. In response to DNA damage, the cell activates several evolut...
Proteomic determinants of response to checkpoint blockade in malignant pleural mesothelioma
PROJECT SUMMARY / ABSTRACT Malignant pleural mesothelioma (MPM) is a fatal cancer of the lining of the lungs that has defeated standard therapies for decades. Immune checkpoint inh...
Impact of brain estrogens on cognition and brain aging in a non-human primate
The goal of the parent grant is to characterize the effects of the aromatase inhibitor letrozole (LET) and the brain-selective estrogen prodrug DHED on (1) behavior; (2) brain elec...
Serial immunotherapy combination to modulate the tumor environment in patients with metastatic gastroesophageal cancer
PROJECT SUMMARY/ABSTRACT Development of effective therapies is an urgent unmet medical need for patients with metastatic gastroesophageal adenocarcinoma (mGEA).The advent of immune...
Nonlinear performance analysis and prediction for robust low dose lung CT
1 PROJECT SUMMARY / ABSTRACT 2 Nonlinear algorithms such as model-based reconstruction (MBR) and deep learning (DL) reconstruction have 3 sparked tremendous research interest in re...
Chemotherapy-driven evolution of the vascular secretome and its role in therapeutic resistance
PROJECT SUMMARY Our continued inability to develop selective therapies that prevent the emergence of disseminated breast tumor cells into lethal metastases necessitates new approac...
Chemotherapy-induced vascular cognitive impairment: role of endothelial senescence
Project Summary Many long-term survivors of cancer experience progressive chemotherapy-induced cognitive impairment (CICI, commonly referred to as chemobrain). Importantly, no stra...
Novel small molecule USP7 Inhibitors for p53 activation and cancer therapy
Project Summary: The long-term objective of this project is to develop a novel targeted therapy for human cancers by reactivating the tumor suppression pathways.Although p53 is fre...
Optimizing Colorectal Cancer Screening among Patients with Diabetes in Safety-Net Primary Care Settings: Targeting Implementation Approaches
ABSTRACT Patients with diabetes mellitus have an estimated 27% elevated risk of developing colorectal cancer (CRC) and are disproportionately Non-Hispanic blacks (NHBs) and Hispani...
Elucidating the role and mechanisms by which collagenase producing intestinal bacteria promote colorectal cancer recurrence and metastasis following surgery.
PROJECT SUMMARY / ABSTRACT Colorectal cancer (CRC) is a major health concern with nearly 2-million new cases of CRC diagnosed worldwide in 2019.While surgical resection of the prim...
Remotely controlled listerial bactodrones for cancer immunotherapy
PROJECT SUMMARY Attenuated and avirulent strains of Listeria monocytogenes (Lm), that are delivered via intravenous injections, accumulate and propagate in primary tumors and metas...
Bcl-2 as a target in cancer
Project Summary Bcl-2, an anti-cell death protein, is overexpressed in about 40% of all human cancers and contributes to the development and progression of cancer.Overexpression of...
Proteomic determinants of response to checkpoint blockade in malignant pleuralmesothelioma
PROJECT SUMMARY / ABSTRACT Malignant pleural mesothelioma (MPM) is a fatal cancer of the lining of the lungs that has defeated standard therapies for decades.Immune checkpoint inhi...