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20,252 grants found
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Ceramide-Rich Platforms Functionalize Gemcitabine Uptake
Our data indicate that in select settings activation of acid sphingomyelinase (ASMase)/ceramide signaling in tumor endothelial cells by radiation and certain chemotherapies synergi...
Early Detection and Diagnosis of Lung Cancer with Endomicroscopy
PROJECT SUMMARY Early diagnosis of lung cancer is critical to patient survival.Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has spread o...
Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor Aggressiveness
Project summary: This project aims to clinically translate hyperpolarized (HP) 13C pyruvate MRI as an innovative metabolic imaging approach for noninvasive prediction of renal tumo...
Using natural language processing to determine predictors of healthy diet and physical activity behavior change in ovarian cancer survivors
ABSTRACT Cancer survivors are a growing population in the United States; more than 16 million currently live in the US and by 2030 this number is expected to exceed 22 million.It i...
Eradication of Escaped Variant Tumor Cells for Cancer Immunotherapy
Project Summary Recently, we discovered that adoptive transfer of CD39KO tumor-specific (mixed CD4+ and CD8+) T cells, resulted in long-term survival of mice bearing large establis...
Emerging Cell Therapies: Realizing the Vision of NextGen Cell Therapeutics
ABSTRACT Support is requested for a Keystone Symposia conference entitled Emerging Cell Therapies: Realizing the Vision of NextGen Smart Cell Therapeutics for Disease organized by...
Impact of brain estrogens on cognition and brain aging in a non-human primate
SUMMARY Aromatase inhibitors (AIs) are drugs that inhibit estrogen synthesis and that are prescribed to prevent the recurrence of estrogen responsive breast cancers.However, AIs, s...
New Statistical Methods for Modelling Cancer Outcomes
PROJECT SUMMARY/ABSTRACT Lung cancer is one of the most common causes of mortality worldwide. Radiomic features have been shown to provide prognostic values in predicting lung canc...
A Leukemia Cell-Specific Coiled-Coil Protein for Treatment of Chronic Myeloid Leukemia
Project Summary/Abstract The long-term goals of this proposal are to explore the protein dimerization interface as an area for therapeutic intervention.Protein dimerization/oligome...
DEHART: Dose-Escalated Hypofractionated Adaptive Radiation Therapy for Head and Neck Cancers
Abstract Locoregional failure remains the principal mode of mortality in head and neck squamous cell carcinomas (HNSCCs) treated with conventional chemoradiation therapy over 7 wee...
Re-engineered Mitochondrially Targeted p53 Gene Therapy in Liver Cancer
Abstract: Hepatocellular carcinoma (HCC), the most common cancer of the liver, is the third leading cause of cancer death worldwide. In the U.S., the overall 5-year survival rate f...
ROS Targeted Therapy for Lethal Prostate Cancer
PROJECT SUMMARY Prostate cancer (PC) is the second leading cause of cancer mortality in American men.Current therapeutics only show marginal efficacy and are often associated with...
Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy
Abstract In the United States, colon cancer and rectal cancer are the third most common cancer diagnosed in both men and women.The standard of care for stage II-III rectal cancer i...
Characterizing the effects of cis-regulatory variation on patient outcomes and treatment response in Multiple Myeloma
ABSTRACT Multiple Myeloma (MM) is a malignancy of plasma cells and the second most common hematological cancer accounting for 2% of cancer deaths. MM is associated with a poor prog...
Elucidating Oncogenic Mechanisms Underlying Wilms Tumor Using Kidney Organoids
PROJECT SUMMARY/ABSTRACT Wilms tumor is the most common pediatric kidney cancer. Blastemal-predominant tumors are classified as high-risk and have demonstrated resistance to chemot...
Exploiting convergent evolution to design biomarker extraction tools for the prediction of therapeutic response in cancer
PROJECT SUMMARY/ABSTRACT The effective treatment of drug resistant tumors represents one of the greatest unmet needs in oncology research. The evolution of therapeutic resistance i...
Ceramide-Rich Platforms Functionalize Gemcitabine Uptake
Our data indicate that in select settings activation of acid sphingomyelinase (ASMase)/ceramide signaling in tumor endothelial cells by radiation and certain chemotherapies synergi...
A Leukemia Cell-Specific Coiled-Coil Protein for Treatment of Chronic Myeloid Leukemia
Project Summary/Abstract The long-term goals of this proposal are to explore the protein dimerization interface as an area for therapeutic intervention. Protein dimerization/oligom...
Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor Aggressiveness
Project summary: This project aims to clinically translate hyperpolarized (HP) 13C pyruvate MRI as an innovative metabolic imaging approach for noninvasive prediction of renal tumo...
Novel small molecule USP7 Inhibitors for p53 activation and cancer therapy
Project Summary: The long-term objective of this project is to develop a novel targeted therapy for human cancers by reactivating the tumor suppression pathways. Although p53 is fr...