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20,252 grants found
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Cold-responsive gene and drug delivery-potentiated cryoimmunotherapy
Project Summary/Abstract Breast cancer (BC) is the 2nd leading cause of cancer-related death in American women and metastasis is the major reason of BC-related mortality. Harnessin...
Investigating the therapeutic potential of a novel glutamine antagonist in KEAP1 mutant lung cancer
PROJECT SUMMARY/ABSTRACT Treating KRAS mutant lung adenocarcinoma (LUAD) remains a major challenge for clinical oncology. Approximately 20% of KRAS mutant LUAD tumors carry loss-of...
A Next-Generation Nucleoside Prodrug for Diffuse Large B-Cell Lymphoma
Project summary Diffuse large B cell lymphoma (DLBCL), a non-Hodgkin’s lymphoma, is the most common hematologic malignancy in the United States, and occurs in both adults and child...
Cross-species development and credentialing of pediatric AML models
PROJECT SUMMARY: The objective of this multi-principal investigator application is to leverage the complimentary expertise of the investigators to develop and credential multiple n...
Deiminated molecules as markers for developing pancreatic cancer - A1
PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDA) carries a dismal prognosis. Understanding the mechanisms that lead to the development of pancreatic cancer and to id...
Ligand-Induced Recruitment of CAR-T Cells to Colorectal Cancers
PROJECT SUMMARY Among the most powerful and successful new therapies to enter the cancer clinic is CAR-T cell therapy. CAR- T cell therapy has been remarkably effective for patient...
Discovery of chemoresistant tumor subclones in pediatric liver cancers
PROJECT SUMMARY The overall survival rate for children with high-risk liver cancer, including metastatic or relapse/refractory hepatoblastoma (HB), hepatocellular carcinoma (HCC),...
ELUCIDATING THE FUNCTION OF P53-MEDIATED IL17RB REPRESSION
ABSTRACT In addition to its pivotal roles in regulating cell cycle arrest, apoptosis, DNA repair, and metabolism, the p53 tumor suppressor has been demonstrated to modulate innate...
MR Image-Guided Drug Delivery to Cerebral Cavernous Malformations with Focused Ultrasound
Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system, affecting ~0.5% of the population. CCM patients experience debilitating neurological pro...
Smoking and Cancer-Related Health Disparities among Sexual and Gender Minority Adults
PROJECT SUMMARY/ABSTRACT In response to PAR-22-072: Measures and Methods to Advance Research on Minority Health and Health Disparities-Related Constructs, this project “Smoking and...
MAIT cell: microbiome crosstalk in antitumor immunity
PROJECT SUMMARY The composition of microorganisms that inhabit the gut, known as the gut microbiome, has been strongly associated with the pathogenesis of several diseases includin...
Identification of metabolic niches in African Americans with colorectal cancer
PROJECT SUMMARY In the United States, colorectal cancer (CRC) mortality is markedly higher in African-American (AA) patients than any other racial or ethnic group. Treatment option...
Targeting Oncogenic PKA signaling mechanisms
ABSTRACT Of the 6,500 known rare diseases, only about 5% have U.S. Food and Drug Administration-approved treatments. In cancer, rare tumors account for approximately 20% of cancer...
Sidney Kimmel Cancer Center LAPS Institutional Collaboration
ABSTRACT The overarching goal of the Sidney Kimmel Cancer Center (SKCC) is to leverage research expertise to reduce the overall incidence, burden, and mortality from cancer in Grea...
Characterizing the biochemical mechanisms of oncogenic signaling by mutant Protein Kinase A
ABSTRACT Of the 6,500 known rare diseases, only about 5% have U.S. Food and Drug Administration-approved treatments. In cancer, rare tumors account for approximately 20% of cancer...
Serum biomarkers to predict immune related adverse events and benefit from single agent pembrolizumab therapy in early stage triple negative breast cancer
Abstract Breast cancer is the most diagnosed cancer and the second leading cause of cancer death in women in the USA. Immune checkpoint therapy (ICI) is revolutionizing the therapy...
Novel 3D DWI for Detection and Characterization of Prostate Cancer in Men with Pelvic Metal Implants
Project Summary Prostate cancer is the most common malignancy and the second leading cause of cancer-related mortality in men in the United States. The American Urological Associat...
Novel 3D DWI for Detection and Characterization of Prostate Cancer in Men with Pelvic Metal Implants
Project Summary Prostate cancer is the most common malignancy and the second leading cause of cancer-related mortality in men in the United States. The American Urological Associat...
Enhancing Tumor Cell Immunogenicity using Improved Molecules Targeting Chromatin Remodeling
PROJECT SUMMARY Few therapies have yet to achieve durable remission of advanced stage triple negative breast cancer (TNBC). One promising approach to improve clinical outcomes is t...
Divergent Functions of ERK2 Substrate Binding Domains in Pathogenesis of KRAS-Driven Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT The central KRAS-ERK signaling axis is activated in most human pancreatic adenocarcinomas (PDAC). Attempts to target ERK1 and ERK2 signaling with non-selec...